导师姓名： 聂红 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： -776364
邮编： 200025 邮箱地址： hnie0823@126.com

研究方向 (点击浏览详细信息)
自身免疫病及肿瘤的发病机制及免疫干预研究

社会任职
上海交通大学医学院免疫学与微生物学系副主任
上海市中医药学会第十届风湿病分会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** CD8+CXCR3+T细胞调控Tfh细胞功能的分子机制及其在系统性红斑狼疮中作用的机制研究 国家自然科学基金面上项目 2017-01~2020-12 57万元 课题负责人
2014CB541803 遗传变异调控AS自身免疫紊乱的分子机制研究 科技部973课题 2014-01~2018-12 110万元 课题参与人
14ZZ106 IL-7/IL-7R调控类风关滑膜炎症和骨破坏分子机制研究 上海市教委创新基金重点项目 2014-01~2016-12 16万元 课题负责人
** 阻断IL-7/IL-7R信号通路治疗类风关细胞与分子机制研究 国家自然科学基金面上项目 2013-01~2016-12 75万元 课题负责人
** TNFa下调类风关Treg细胞磷酸化Foxp3表达及促进Th17细胞分化机制研究 国家自然科学基金面上项目 2011-01~2013-12 30万元 课题负责人
** Qa-1限制性调节性CD8+T细胞系建立、特性及效应机制研究 国家自然科学基金面上项目 2009-01~2011-12 26万元 课题负责人
09YZ102 Qa-1限制性调节性CD8+T细胞系建立及其生物学特性研究 上海市教委创新基金 2009-01~2011-12 8万元 课题负责人
2008XJ005 抗TNF-a抗体治疗类风关分子机制研究 医学院基金 2008-07~2010-06 5万元 课题负责人
2008HX006 EGCG对胶原诱导的关节炎免疫调节机理研究 横向课题 2008-01~2009-10 5万元 课题负责人
06BZ022 EGCG和Andro联合用药治疗RA作用机制研究 上海市教委发展基金 2007-01~2008-12 6万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jiang Y, Chen M, Nie H （通讯作者）, Yuan Y PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations Human Vaccines & Immunotherapeutics 2019 **
Wei W, Wang Y, Sun Q, Jiang C, Zhu M, Song C, Li C, Du G, Deng Y, Nie H, Tang G. Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus J Oral Pathol Med 2019 doi: 10.1111/jop.12938
Xu H, Cai L, Zhang L, Wang G, Xie R, Jiang Y, Yuan Y, Nie H. （通讯作者） Paeoniflorin ameliorates collagen-induced arthritis via suppressing nuclear factor-kB signalling pathway in osteoclast differentiation Immunology 2018 154: 593-603
Wang Y, Shang S, Sun Q, Chen J, Du G, Nie H, Han X, Tang G Increased infiltration of CD11 c+/CD123+ dendritic cell subsets and upregulation of TLR/IFN-α signaling participate in pathogenesis of oral lichen planus Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 125(5):459-467
Wei J, Wu J, Xu W, Nie H, Zhou R, Wang R, Liu Y, Tang G, Wu J. Salvanic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1?signaling pathway Cell Death Dis 2018 9(6): 599
Zheng Y, Huang L, Ge W, Yang M, Ma Y, Xie G, Wang W, Bian B, Li L, Nie H, Shen L. Protein arginine methyltransferase 5 inhibition upregulates Foxp3+ regulatory T cells frequency and function during the ulcerative colitis Front Immunol 2017 8: 596
Han Zhang, Yuanyuan Qi, Yuanyang Yuan, Li Cai, Haiyan Xu, Lili Zhang, Bing Su, Hong Nie. （通讯作者） Paeoniflorin ameliorates experimental autoimmune encephalomyelitis via inhibition of dendritic cell function and Th17 cell differentiation. Sci Rep 2017 7: 41887
Li Cai, Haiyan Xu, Han Zhang, Lili Zhang, Guojue Wang, Hong Nie. （通讯作者） Blockade of IL-7Rα alleviates collagen-induced arthritis via inhibiting Th1 cell differentiation and CD4+ T cell migration. Mol Immunol. 2016 79: 83-91
Zheng Y, Sun L, Jiang T, Zhang D, He D, Nie H （通讯作者） TNFa promotes Th17 cell differentiation through IL-6 and IL-1b produced by monocytes in rheumatoid arthritis J Immunol Res 2014 385352:1-12
Quanye Sun,Yingxia Zheng, Xia Zhang, Xiaojuan Hu, Yuanxia Wang, Shimin Zhang, Dongqing Zhang, Hong Nie （通讯作者） Novel immunoregulatory properties of EGCG on reducing inflammation in EAE Frontiers in Bioscience, Landmark 2013 18:332-342
Hong Nie, Yingxia Zheng, Runsheng Li, Taylor B Guo, Dongyi He, Lei Fang, Xuebin Liu,Lianbo Xiao, Xi Chen, Bing Wan, Y Eugene Chin, Jingwu Z Zhang Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis Nat. Med. 2013 19(3): 322-328
Qianqian Yin, Chuanxu Liu, Yingli Wu, Shaofang Wu, Yan Wang, Xia Zhang, Xiaojuan Hu, Jianxin Pu, Ying Lu, Huchen Zhou, Honglin Wang, Hong Nie, Handong Sun, Guoqiang Chen. Preventive and therapeutic effects of adenanthin on experimental autoimmune encephalomyelitis by inhibiting NF-?B signaling J Immunol 2013 191(5): 2115-2125
Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng, Hong Nie （通讯作者）, Min Jin, Huanbai Xu Stimulation of TLR4 by LMW-HA induces metastasis in human papillary thyroid carcinoma through CXCR7 Clin Dev Immunol 2013 712561:1-9
Chaoying Hu, Liu Qian, Yi Miao, Qiuyu Huang, Ping Miao, Ping Wang, Qiwen Yu, Hong Nie, Jiying Zhang, Dongyi He, Rong Xu, Xuehua Chen, Bingya Liu, Dongqing Zhang. Antigen-presenting effects of effector memory V?9V?2 T cells in rheumatoid arthritis Cell Mol Immunol 2012 9(3):245-54
Chen M, Chen G, Nie H, Zhang X, Niu X, Zang YC, Skinner SM, Zhang JZ, Killian JM, Hong J Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4(+) T Cells in MS Eur J Immunol 2009 39(9):2525-2536
Gong F, Ma Y, Ma A, Yu Q, Zhang J, Nie H, Chen X, Shen B, Li N, Zhang D A lectin from Chinese mistletoe increases gammadelta T cell-mediated cytotoxicity through induction of caspase-dependent apoptosis Acta Biochim Sin 2007 39:445-452
Hong Nie, Jiliang Wu, Miao Zhang, Jian Xu, Minghui Zou Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo Diabetes 2006 55(11):3133-3141
Jian Hong, Ying Zang, Hong Nie, and Jingwu Z. Zhang CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis PNAS 2006 103(13):5024-5029
Bin Wan, Hong Nie, Ailian Liu, Guozhang Feng, Dongyi He, Rong Xu, Qi Zhang, Chen Dong, Jingwu Z. Zhang Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis J Immunol 2006 177(12): 8844-8850
Guangwu Xu, Hong Nie （共同第一作者）, Ningli Li, Wenxin Zheng, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, Jian Hong, and Jingwu Z. Zhang Role of osteopontin in amplification and perpetuation of rheumatoid synovitis J Clin Invest 2005 115(4):1060-1067
Guangwu Xu, Wei Sun, Dongyi He, Li Wang, Wenxin Zheng, Hong Nie, Liqing Ni, Dongqing Zhang, Ningli Li, Jingwu Zhang Overexpression of osteopontin in rheumatoid synovial mononuclear cells is associated with joint inflammation, not with genetic polymorphism J Rheumatol 2005 32(3): 410-416
Wei Sun, Hong Nie （共同第一作者）, Ningli Li, Ying C.Q. Zang, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, S Prasad, RR Robinson, W Ho, E Sercarz, and JZ Zhang Skewed T-cell receptor BV14 and BV16 expression and shared CDR3 sequence and common sequence motifs in synovial T cells of rheumatoid arthritis Genes Immun 2005 6(3):248-261
Ningli Li, Hong Nie, Qiwen Yu, Jiying Zhang, Anlun Ma, Baihua Shen, Li Wang, Jun Bai, Xuehua Chen, Tong Zhou, Dongqing Zhang The role of sFasL in autoimmune disease. W.J.Gastregon 2004 10(21): 3151-3156