导师姓名： 钟清 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市重庆南路280号西2号楼1005
邮编： 200025 邮箱地址： qingzhong@shsmu.edu.cn

研究方向 (点击浏览详细信息)
开展针对自噬的药物筛选
自噬和疾病之间的关系研究
氧化应激坏死的功能探索
细胞坏死的生化机制研究
自噬的生化机理研究

社会任职
F1000Prime专家成员
Journal of Biological Chemistry编委
中国细胞生物学学会细胞器分会副会长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
1 细胞自噬体，溶酶体及内质网的相互作用及调控 国家自然科学基金重大研究计划重点支持项目 2018-01~2022-12 255万元 课题负责人
2 营养感受激酶mTORC1对自噬特异的脂质磷酸化激酶的关键性调控机制研究 国家自然科学基金面上项目 2018-01~2021-12 61万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Ding B, Zhong Q （通讯作者） Zinc deficiency: An unexpected trigger for autophagy. J Biol Chem. 2017 292(20):8531-8532. May 19; 292(20):8531-8532.
a X, Zhang S, He L, Liu R, Wilz L, Sun Q, Fan W, Chen S, Yue Z, Kim J, Guan KL, Li D, Zhong Q （通讯作者） MTORC1 mediated NRBF2 phosphorylation functions as a switch for PI3KC3 and autophagy. Autophagy 2017 13(3):1
Li L, Zhong Q. （通讯作者） Autophagosome-lysosome fusion: PIs to the rescue. EMBO J. 2016 Sep 1; 35(17):1845-7.
Cao M, Zhong Q. （通讯作者） Cilia in autophagy and cancer. Cilia 2016 Feb 3;5:4
Diao J, Liu R, Rong Y, Zhao M, Zhang J, Lai Y, Zhou Q, Wilz L, Li J, Vivona S, Pfuetzner R, Brunger A, Zhong Q. （通讯作者） ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. Nature 2015 Apr 23; 103(5): 1244-1251.
Levine B, Liu R, Dong Xu, Zhong Q. （通讯作者） Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology. Trends Cell Biol. 2015 Jun 11; S0962-8924(15)
Liu R, Zhi X, Zhong Q. （通讯作者） ATG14 controls SNARE-mediated autophagosome fusion with a lysosome. Autophagy 2015 11(5):847-9
Zhi X, Zhong Q. （通讯作者） Autophagy in cancer. F1000Prime Rep. 2015 Feb 3;7:18
Levine B, Liu R, Dong Xu, Zhong Q. （通讯作者） Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology. Trends Cell Biol. 2015 Jun 11; S0962-8924(15)
Zhang J, Zhong Q （通讯作者） Histone deacetylase inhibitors and cell death. Cell Mol Life Sci. 2014 Oct;71(20):3885-901
Tang Z, Zhu M, Zhong Q. （通讯作者） Self-eating to remove cilia roadblock. Autophagy 2014 Feb;10(2):379-81.
Nazarko V, Zhong Q （通讯作者） ULK1 phosphorylates Beclin 1 in autophagy. Nat Cell Biol, 2013 July 1;15(7):727-8.
Kim J, Kim Y, Fang C, Russell R, Kim J, Fan W, Liu R, Zhong Q, Guan KL. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Jan 17;152(1), 290-303 Cell 2013 Jan 17;152(1), 290-303
Tang Z, Lin MG, Stowe TR, Chen S, Zhu M, Stearns T, Franco B, Zhong Q. （通讯作者） Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. Nature 2013 Oct 2;502, 254-257.
Chen D, Zhong Q. （通讯作者） A tethering coherent protein in autophagosome maturation. Autophagy 2012 Jun;8(6):985-6
17.Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang PA, Ohashi PS, Zhong Q, Wang X, Mak TW. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med. 2012 Jan 16;209(1):173-86.
Yan X, Sun Q, Ji J, Zhu Y, Liu Z, Zhong Q （通讯作者） Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro. Autophagy 2012 Feb 1;8(2):213-21.
Chen D, Fan W, Lu Y, Ding X, Chen S, Zhong Q. （通讯作者） A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Mol Cell 2012 Mar 9;45(5):629-41.
Kim HJ, Zhong Q, Sheng ZH, Yoshimori T, Liang C, Jung JU. Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J Cell Sci. 2012 Oct 15;125(Pt 20):4740-50
Wilz L, Fan W, Zhong Q （通讯作者） Membrane curvature response in autophagy. Autophagy 2011 Oct;7(10):1249-50.
Zhang J, Kan S, Huang B, Hao Z, Mak TW, Zhong Q. （通讯作者） Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2. Genes Dev 2011 Dec 15;25(24):2610-8.
Fan W, Nassiri A, Zhong Q. （通讯作者） Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L). Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7769-7774
Sun Q, Zhang J, Fan W, Wong KN, Ding X, Chen S, Zhong Q （通讯作者） The RUN domain of Rubicon is important for hVPS34 binding, lipid kinase inhibition and autophagy suppression. J Biol Chem. 2011 Jan 7;286(1):185-91
Lin MG, Zhong Q. （通讯作者） Interaction between small GTPase Rab7 and PI3KC3 links autophagy and endocytosis: A new Rab7 effector protein sheds light on membrane trafficking pathways. Small GTPases. 2011 Mar;2(2):85-88.
Sun Q, Westphal W, Wong K, Tan I, Zhong Q （通讯作者） Rubicon controls endosome maturation as a Rab7 effector. Proc Natl Acad Sci U S A. 2010 Nov 9; 107(45):19338-43
Fan W, Tang Z, Chen D, Moughon D, Ding X, Chen S, Zhu M, Zhong Q. （通讯作者） Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy 2010 July 22;6(5):614-21.
Sun Q, Fan W, Zhong Q. （通讯作者） Regulation of Beclin 1 in autophagy. Autophagy 2009 Jul 24;5(5):713-6.
Sun Q, Fan W, Chen K, Ding X, Chen S, Zhong Q. （通讯作者） Identification of Barkor as a Mammalian Autophagy-Specific Factor for Beclin 1 and Class III Phosphatidyl-inositol 3-Kinase. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19211-6
Ding Q, He X, Hsu JM, Xia W, Chen CT, Li LY, Lee DF, Liu JC, Zhong Q, Wang X, Hung MC. Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol. 2007 Jun;27(11):4006-17.
Hall JR, Kow E, Nevis KR, Lu CK, Luce KS, Zhong Q, Cook JG. Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage. Mol Cell Biol. 2007 Sep;18(9):3340-50.
Yun J, Zhong Q, Kwak JY, Lee WH. Hypersensitivity of Brca1-deficient MEF to the DNA interstrand crosslinking agent mitomycin C is associated with defect in homologous recombination repair and aberrant S-phase arrest. Oncogene. 2005 Jun 9;24(25):4009-16.
Zhong Q, Gao W, Du F, Wang X. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 2005 121(7): 1085-1095
Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F, Wang X. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 2003 17(12):1475-1486.
Zhong Q, Chen C-F, Chen P-L, and Lee W-H BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J Biol Chem. 2002 Aug 9;277 (32):28641-28647
Zhong Q, Boyer TG, Chen P-L, and Lee W-H Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res. 2002 Jul 15;62 (14):3966-3970.
Dong Z., Zhong Q, and Chen P-L The Nijmegen Breakage Syndrome Protein Is Essential for Mre11 Phosphorylation upon DNA Damage. J Biol Chem. 1999 274:19513-19516
Zhong Q, Chen C-F, Li S, Chen Y, Wang C-C, Xiao J, Chen P-L, Sharp ZD, and Lee WH: Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response. Science 1999 Jul 30;285: 747-750
Zhong Q, Chen Y, Jones D, and Lee W-H Perturbation of TSG101 Protein Affects Cell Cycle Progression. Cancer Res. 1998 58: 2699-2702
Zhong Q, Chen C-F, Chen Y, Chen P-L, and Lee W-H Identification of Cellular TSG101 Protein in Multiple Human Breast Cancer Cell Lines. Cancer Res. 1997 57: 4225-4228