导师姓名： 余健秀 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： Email Address:Jianxiu.Yu@gmail.com;Jianxiu.Yu@shsmu.edu.cn;电话：
邮编： 200025 邮箱地址： Jianxiu.Yu@Gmail.com

研究方向 (点击浏览详细信息)
蛋白质修饰、RNA修饰与肿瘤发生发展

社会任职
担任中国抗癌协会肿瘤标志专业委员会“非编码与肿瘤研究”专家委员会副组长；担任国际著名杂志杂志Nature, Cancer Research, Oncogene, CMLS, FEBS J, JBC等审稿专家

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** PTEN在DNA损伤修复中介导组蛋白H2A/H3修饰调控前列腺癌发生发展 国家自然科学基金重点项目 2017-01~2021-12 275万元 课题负责人
** Ago2乙酰化在miRNA途径中的功能与机制 国家自然科学基金面上项目 2017-01~2020-12 65万元 课题负责人
** Shp2类泛素（SUMO）化修饰促进ERK信号通路激活而加速肝癌发生发展 国家自然科学基金面上项目 2015-01~2018-12 74万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhao X#, Wang Y#, He J#, Deng R, Huang X, Guo Y, Li L, Xie R*, Yu J*. （通讯作者） LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells Mol Carcinog. 2020 59(10):1174-1187
Dou J#, Zhang H#, Chen R#, Shu Z, Yuan H, Zhao X, Wang Y, Huang J, Zhou A*, Yu J*. （通讯作者） SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells Mol Oncol 2020 14(9):2288-2312
Liu T#, Zhang H#, Fang J, Yang Z, Chen R, Wang Y, Zhao X, Ge S, Yu J* （通讯作者）, Huang J*. AGO2 phosphorylation by c-Src kinase promotes tumorigenesis Neoplasia 2020 22(3):129-141
Lin R, Zhan M, Yang L, Wang H, Shen H, Huang S, Huang X, Xu S, Zhang Z, Li W, Liu Q, Shi Y, Chen W, Yu J* （通讯作者）, Wang J*. Deoxycholic Acid Modulates the Progression of Gallbladder Cancer Through N 6-methyladenosine-dependent microRNA Maturation Oncogene 2020 39(26):4983-5000
Zhang H#, Wang Y#, Dou J#, Guo Y, He J, Li L, Liu X, Chen R, Deng R, Huang J, Xie R, Zhao X*, Yu J*. （通讯作者） Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis Oncogene 2019 38(9):1410-1431
Cui N, Liu T, Guo Y, Dou J, Yang Q, Zhang H, Chen R, Wang Y, Zhao X, Yu J* （通讯作者）, Huang J*. SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function Neoplasia 2019 21(7):676-688.
Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, Jiang B, Xu M, Cheng J, Chen GQ, Zhao X*, Yu J* （通讯作者） SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function Nucleic Acids Res 2018 46(10) 5195-5208.
Chen Q*, Deng R, Zhao X, Yuan H, Zhang H, Dou J, Chen R, Jin H, Wang Y, Huang J, Yu J*. （通讯作者） SUMOylation of EphB1 suppresses neuroblastoma tumorigenesis via inhibiting PKCγ activation. Cellular Physiology and Biochemistry 2018 45:2283-2292.
Jiang H, Deng R, Yang X, Shang J, Lu S, Zhao Y, Song K, Liu X, Zhang Q, Chen Y, Chinn YE, Wu G, Li J, Chen G, Yu J* （通讯作者）, Zhang J*. Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nature Chem Biol 2017 13(9):994-1001
Wang J, Deng R, Cui N, Zhang H, Liu T, Dou J, Zhao X, Chen R, Wang Y, Yu J* （通讯作者）, Huang J* Src SUMOylation Inhibits Tumor Growth Via Decreasing FAK Y925 Phosphorylation. Neoplasia 2017 19(12):961-971
Zhao X, Deng R, Wang Y, Zhang H, Dou J, Li L, Du Y, Chen R, Cheng J, Yu J*. （通讯作者） Twist1/Dnmt3a and miR186 establish a regulatory circuit that controls inflammation-associated prostate cancer progression. Oncogenesis 2017 6(4): e315.
Yuan H, Deng R, Zhao X, Chen R, Hou G, Zhang H, Wang Y, Xu M, Jiang B*, Yu J* （通讯作者） SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis Mol Cancer 2017 16(1):157
Zhu C, Chen C, Chen R, Deng R, Zhao X, Zhang H, Duo J, Chen Q, Jin H, Wang Y, Huang J, Xu M, Yu J* （通讯作者） K259-SUMOylation of DGCR8 promoted by p14ARF exerts a tumor-suppressive function J Mol Cell Biol 2016 8(5),456–458
Zhao X, Wang Y, Deng R, Zhang H, Dou J, Yuan H, Hou G, Du Y, Chen Q, Yu J*. （通讯作者） miR186 suppresses prostate cancer progression by targeting Twist1 Oncotarget 2016 7(22): 33136-51
Xu M, Zhu C, Zhao X, Chen C, Zhang H, Yuan H, Deng R, Dou J, Wang Y, Huang J, Chen Q, Jiang B, Yu J* （通讯作者） Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors Oncotarget 2015 6(2): 979-94
Chen Q, Zhao X, Zhang H, Yuan H, Zhu M, Sun Q, Lai X, Wang Y, Huang J, Yan J, Yu J* （通讯作者） MiR-130b suppresses prostate cancer metastasis through down-regulation of MMP2 Molecular Carcinogenesis 2015 54(11):1292-300
Zhu C, Chen C, Huang J, Zhang H, Zhao X, Deng R, Dou J, Jin H, Chen R, Xu M, Chen Q, Wang Y, Yu J* （通讯作者） SUMOylation at K707 of DGCR8 controls direct function of primary microRNA Nucleic Acids Res. 2015 43(16):7945-60
Deng R, Zhao X, Qu Y, Chen C, Zhu C, Zhang H, Yuan H, Jin H, Liu X, Wang Y, Chen Q, Huang J, Yu J* （通讯作者） Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development Oncotarget 2015 6(11):9355-69
Chen C, Zhu C, Huang J, Zhao X, Deng R, Zhang H, Dou J, Chen Q, Xu M, Yuan H, Wang Y, Yu J* （通讯作者） SUMOylation of TARBP2 regulates miRNA/siRNA efficiency Nature Communications 2015 6:9899
Lai X, Chen Q, Zhu C, Deng R, Zhao X, Chen C, Wang Y, Yu J* （通讯作者）, Huang J* Regulation of RPTPα-c-Src signalling pathway by miR-218. FEBS J. 2015 282(14):2722-34
Lu S#, Deng R#, Jiang H#, Song H#, Li S, Shen Q, Huang W, Nussinov R, Yu J* （通讯作者）, Zhang J* The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation. Structure 2015 23(9):1725-34
Qu Y, Chen Q, Lai X, Zhu C, Chen C, Zhao X, Deng R, Xu M, Yuan H, Wang Y, Yu J* （通讯作者）, Huang J* SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1 Mol Cancer 2014 13(1):95
Sun Q, Zhao X, Liu X, Wang Y, Huang J, Jiang B, Chen Q, Yu J* （通讯作者） miR-146a functions as a tumor suppressor in prostate cancer by targeting Rac1. Prostate 2014 74(16):1613-21
Zhu M, Chen Q, Liu X, Sun Q, Zhao X, Deng R, Wang Y, Huang J, Xu M, Yan J, Yu J* （通讯作者） lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI FEBS J. 2014 281:3766-3775
Liu X, Chen Q, Yan J, Wang Y, Zhu C, Chen C, Zhao X, Xu M, Sun Q, Deng R, Zhang H, Qu Y, Huang J, Jiang B, Yu J* （通讯作者） MiRNA-296-3p-ICAM-1 axis promotes metastasis of prostate cancer by possible enhancing survival of natural killer cell-resistant circulating tumour cells. Cell Death Dis. 2013 21;4:e928
Yu J* （通讯作者）, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS* Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1 and SH2-tyrosine phosphatase Shp2. J Biol Chem 2013 288(6):3823-30
Liu X, Wang Y, Sun Q, Yan J, Huang J, Zhu S, Yu J* （通讯作者） Identification of microRNA transcriptome involved in human natural killer cell activation Immunol Lett 2012 143(2):208-17
Yu J, Zhang D, Liu J, Li J, Yu Y, Wu XR, Huang C RhoGDI SUMOylation at Lys-138 Increases Its Binding Activity to Rho GTPase and its Inhibiting Cancer Cell Motility J Biol Chem 2012 287:13752-60
Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J* （通讯作者） SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane Nature Communications 2012 3:911-925
Yu J* （通讯作者）, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E*, Mustelin T. PTEN regulation by Akt-EGR1-ARF-PTEN axis EMBO J 2009 28:21-33
Yu J, Baron V, Mercola D, Mustelin T, Adamson ED A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells Cell Death and Differentiation 2007 14:436-446
Yu J, de Belle I, Liang H, Adamson ED Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses Molecular Cell 2004 15: 83-94