导师姓名： 孙海鹏 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： sunhaipeng@shsmu.edu.cn

研究方向 (点击浏览详细信息)
代谢稳态调控与疾病

社会任职
中国中药协会微循环用药专业委员会常务委员
中国病理生理学会内分泌与代谢专业委员会委员
中国病理生理学会心血管专业委员会青年委员
Clinical and Experimental Pharmacology and Physiology编委
国际心脏研究会（ISHR）中国分会会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
16JC** 氨基酸营养信号在代谢调控网络中的新功能与新机制研究 上海市科委科技创新行动计划 2016-07~2019-06 50万元 课题参与人
** 支链氨基酸代谢紊乱影响糖代谢的机制与转化医学研究 国家自然基金委面上项目 2016-01~2019-12 69.6万元 课题负责人
2013YQ030923 超高分辨率PET的开发和应用 国家重大科学仪器设备开发专项 2013-10~2017-09 80万元 课题参与人
** 支链氨基酸在心力衰竭过程中的功能及相关研究 国家自然基金委面上项目 2013-01~2016-12 70万元 课题负责人
12PJ** 支链氨基酸对心力衰竭的影响及相关研究 上海市科委浦江人才计划项目 2012-10~2014-09 20万元 课题负责人
2012BAI02B05 系统生物学对代谢疾病的机制和转化的研究 科技部十二五支撑计划项目 2012-01~2015-12 380万元 课题参与人
mTORC2的调控机制及其在支链氨基酸调节的心肌细胞死亡中的功能研究 上海市科委国际合作项目 2011-12~2013-12 25万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Mengping Chen, Chen Gao, Jiayu Yu, Shuxun Ren, Menglong Wang, Richard Wynn, David Chuang, Yibin Wang, Haipeng Sun （通讯作者） Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-overload Induced Heart Failure Journal of the American Heart Association 2019 DOI: 10.1161/JAHA.118.011625
Meiyi Zhou, Jing Shao, Cheng-Yang Wu, Le Shu, Weibing Dong, Yunxia Liu, Mengping Chen, R. Max Wynn, Jiqiu Wang, Ji Wang, Wen-Jun Gui, Xiangbing Qi, Aldons J. Lusis, Zhaoping Li, Weiqing Wang, Guang Ning, Xia Yang, David T. Chuang, Yibin Wang, Haipeng Sun （通讯作者） Targeting BCAA Catabolism to Treat Obesity-associated Insulin Resistance Diabetes 2019 doi: 10.2337/db18-092
Liu X, Zhang F, Zhang Y, Li X, Chen C, Zhou M, Yu Z, Liu Y, Zhao Y, Hao X, Tang Y, Zhu L, Liu L, Xie L, Gu H, Shao H, Xia F, Yin C, Tao M, Xie J, Zhang CC, Yang Y, Sun H （通讯作者）, Chen GQ, and Zheng J PPM1K regulates hematopoiesis and leukemogenesis through CDC20-mediated ubiquitination of MEIS1 and p21 Cell Reports 2018 23(5):1461–1475
Yunxia Liu, Weibing Dong, Jing Shao, Yibin Wang, Meiyi Zhou, Haipeng Sun. （通讯作者） Branched-chain amino acid negatively regulates KLF15 expression via PI3K-AKT pathway Frontiers in Physiology 2017 8:853
Dong W,Zhou M,Dong M,Pan B,Liu Y,Shao J,Gu X,Huang Y,Li G,Wang Y,Sun H （通讯作者） Keto Acid Metabolites of Branched-Chain Amino Acids Inhibit Oxidative Stress-Induced Necrosis and Attenuate Myocardial Ischemia-Reperfusion Injury J Mol Cell Cardiol 2016 101(): 90-98
Sun H, Wang Y Branched Chain Amino Acid Metabolic Reprogramming in Heart Failure Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2016 1862(12):2270-2275
Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, Williams NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure Circulation 2016 133(21):2038-49
Meng J, Feng M, Dong W, Zhu Y, Li Y, Zhang P, Wu L, Li M, Lu Y, Chen H, Liu X, Lu Y, Sun H, Tong X Identification of HNF-4α as a key transcription factor to promote ChREBP expression in response to glucose Sci Rep 2016 6:23944
Fan H, Dong W, Li Q, Zou X, Zhang Y, Wang J, Li S, Liu W, Dong Y, Sun H （通讯作者）, Hou Z Ajuba preferentially binds LXRα/RXRγ heterodimer to enhance LXR target gene expression in liver cells Mol Endocrinol 2015 29(11):1608-18
Sun H, Wang Y The Elusive Philosopher’s Stone in Young Blood Circulation Research 2015 117(11):906-8
Sun H, Chen G, Wang Y A H(a)rd Way to Adapt in Cardiac Hypertrophy Circulation Research 2015 117(6):484-6
Pan B, Chen G, Ren S, Wang Y, Sun H （通讯作者）, Zhou M Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells Acta Pharmacologica Sinica 2015 36: 1480–1486
Yuan Y, Pan B, Sun H, Chen G, Su B, Huang Y Characterization of Sin1 Isoforms Reveals an mTOR-Dependent and Independent Function of Sin1γ PLoS One 2015 10(8):e**
Cai R, Gu J, Sun H （共同第一作者）, Liu X, Mei W, Qi Y, Xue S, Ren S, Rabinowitz JE, Wang Y, Yeh ET, Cheng J Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy J Mol Cell Cardiol. 2014 79C:115-122
Sun H, Wang Y Interferon Regulatory Factors in Heart: Stress Response beyond Inflammation Hypertension 2014 63(4):663-4
Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK Klf15 orchestrates circadian nitrogen homeostasis Cell Metabolism 2012 15(3):311-23
Sun H, Wang Y Novel Ser/Thr protein phosphatases in cell death regulation Physiology 2012 27(1):43-52
Zhou M, Gao C, Lu G, Wang Y, Sun H （通讯作者） Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm) J Biol Chem 2012 287(28):23397-406
Sun H, and Wang Y Prostaglandin E2 in remote control of myocardial remodeling Circulation 2012 125(23):2818-20
Sun H, Lu G, Ren S, Chen J, and Wang Y. Catabolism of Branched-Chain Amino Acids in Heart Failure: Insights from Genetic Models Pediatric Cardiology 2011 32(3):305-10
Huang Y, Zhou M, Sun H, and Wang Y Branched-Chain Amino Acids Metabolism in Heart Disease - An Epiphenomenon or A Real Culprit? Cardiovascular Research 2011 90(2):220-3
Sun H, Wang Y Restriction of Big Hearts by a Small RNA Circulation Research 2011 108(3):274-6
Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest 2009 119(6):1678-87