导师姓名： 邓炯 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： jiongdeng@shsmu.edu.cn
邮编： 200025 邮箱地址： jiongdeng@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肺癌发生的分子机理及防治研究

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
肺干细胞恶性转化的分子机理 国家自然科学基金国际合作重大项目 2017-01~2021-12 240万元 课题负责人
2013CB910901 赖氨酸残基多种翻译后修饰对蛋白质功能的调控作用 国家科技委 973重点基础科研项目 2013-01~2016-12 80万元 课题参与人
** 肺慢性炎症恶性转化的分子机制 国家自然科学基金重大研究计划/重点支持项目 2012-01~2015-12 300万元 主要责任人
基于Gprc5a-敲除小鼠的肺肿瘤发生机制研究 国家自然科学基金/面上项目 2011-01~2014-12 40万元 主要责任人

学术论文 作者论文标题期刊名出版年卷期页码
Liu S*, Ye, D*, Xu D, Liao Y, Zhang L, Liu L, Yu W, Wang Y, He Y, Hu J, Guo W, Wang T, Sun B, Song H, Yin H, Liu J, Wu Y, Zhu H, Zhou BP （通讯作者）, Deng J *, Zhang Z* Autocrine Epiregulin Activates EGFR Pathway for Lung Metastasis via EMT in Salivary Adenoid Cystic Carcinoma. Oncotarget 2016 7(18): 25251-63
Wang X, Xu D, Liao Y, Zhong S, Song H, Sun B, Zhou BP, Deng J* （通讯作者）, Han B,* Epithelial Neoplasia Coincides with Exacerbated Injury and Fibrotic Response in the Lungs of Gprc5a-knockout Mice Following Silica Exposure Oncotarget 2015 6(37):39578-93, 2015
Liu S, Ye D, Guo W, Yu W, He Y, Hu J, Wang Y, Zhang L, Liao Y, Song H, Zhong S, Xu D, Yin H, Sun B, Wang X, Liu J, Wu Y, Zhou BP*, Zhang Z*, Deng J （通讯作者） G9a is Essential for EMT-mediated Metastasis and Maintenance of Cancer Stem Cell-like Characters in Head and Neck Squamous Cell Carcinoma Oncotarget 2015 6(9):6887-901
Zhong S, Yin H, Liao Y, Yao F, Li Q, Zhang J, Jiao H, Zhao Y, Xu D, Liu S, Song H, Gao Y, Liu J, Ma L, Pang Z, Yang R, Ding C, Sun B, Lin X, Ye X, Guo W, Han B, Zhou BP, Chin YE, and Deng J （通讯作者） Lung tumor suppressor GPRC5A binds EGFR and restrains its effector signaling Cancer Research 2015 75(9):1801-1814
Zhang L, Ke F, Liu Z, Bai J, Liu J, Yan S, Xu Z, Lou F, Wang H, Zhu H, Sun Y, Cai W1, Gao Y, Li Q, Yu XZ, Qian Y, Hua Z, Deng J, Li QJ, Wang H MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3 Nature Communication 2015 6:7639-7651
Liao Y, Song H, Xu D, Jiao H, Yao F, Liu J, Wu Y, Zhong S, Yin H, Liu S, Wang X, Guo W, Sun B, Han B, Chin YE, and Deng J （通讯作者） Gprc5a-deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-kappaB pathway Cell Cycle 2015 14(9):1403-1412
Lin X, Zhong S, Ye X, Liao Y, Yao F, Yang X, Sun B, Zhang J, Li Q, Gao Y, Wang Y, Liu J, Han B, Chin YE, Zhou BP, Deng J （通讯作者） EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer Molecular Cancer 2014 13(1):233-244
Shi J, Wang Y, Zeng L, Wu Y, Deng J, Zhang Q, Lin Y, Li J, Kang TB, Tao M, Rusinova E, Zhang GT, Wang C, Zhu H, Yao J, Zeng YX, Evers BM, Zhou MM, Zhou BP Disrupting the Interaction of BRD4 with Di-acetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer Cancer Cell 2014 25(2):210-225
Shu-li Liu, Shuang-shuang Zhong, Dong-xia Ye, Wan-tao Chen, Zhi-yuan Zhang, Jiong Deng. （通讯作者） Repression of G protein–coupled receptor family C group 5 member A is associated with pathologic differentiation grade of oral squamous cell carcinoma Journal of Oral Pathology & Medicine 2013 42(10):761-768
Jingyi Liu, Yueling Liao, Kewei Ma, Yonglu Wang, Guoxiang Zhang, Rongcun Yang, Jiong Deng. （通讯作者） PI3K is required for the physical interaction and functional inhibition of NF-kappaB by beta-catenin in colorectal cancer cells Biochemical and Biophysical Research Communications 2013 434(4):760-766
Chen Y, Deng J, Fujimoto J, Kadara H, Men T, Lotan D, Lotan R. Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor. Cancer Research 2010 70(21):8917-26
Deng （共同第一作者）, J. Fujimoto, J, Ye, X, Men, T, Van Pelt, CS, Chen, Y, Lin, X, Tao, Q, Lacroix, L, Lee, JJ, Lotan, D, and Lotan, R. Gprc5a-knockout leads to NF-kB activation in airway epithelium and promotes lung inflammation and tumorigenesis. Cancer Prev Res (Phila Pa) 2010 3(4):424-37
Wu Y, Deng J, Rychahou PG, Qia S, Evers MB. and Zhou BP. Stabilization of Snail by NF-kB is required for inflammation induced cell migration and invasion. Cancer Cell 2009 15(5):416-28