导师姓名： 周爱武 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海重庆南路280号5号楼201室.-776909
邮编： 200025 邮箱地址： awz20@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤免疫治疗的分子机制

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 血管收缩素原结构与功能调控机制研究。 国家自然科学基金（面上项目） 2019-01~2022-12 57万元 课题负责人
5 热休克蛋白47（HSP47）抑制剂的发现、优化及其在抗纤维化疾病中的作用研究 青年科学基金 2017-01~2019-12 17.9万元 课题参与人
3 病原菌核糖体新调节因子的系统发现及蛋白质相互作用网络的建设 国家重点研发计划 2017-01~2021-12 100万元 课题参与人
4 脯氨酸羟化酶复合物在胶原合成过程中的分子机制 国家自然科学（面上项目） 2016-01~2019-12 60万元 课题负责人
1 天然小分子化合物腺花素抑制过氧化物氧还酶的生物学机制研究 国家自然科学基金（面上项目） 2014-01~2017-12 80万元 课题负责人
2 新型离子通道结构功能研究 973重大研究计划(研究骨干) 2014-01~2018-12 110万元 课题参与人
6 淋巴瘤中ABIN 家族基因表达和基因突变分析及其突变体的功能研究， 国家自然科学基金面上项目 2014-01~2017-12 73万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Mykhaylo Demydchuka, Chris H. Hilla, Aiwu Zhou,GáborBunkóczia, Penelope E. Steinc, Denis Marchesanc, Janet E. Deanea and Randy J. Reada Insights into Hunter syndrome from the structure of iduronate-2-sulfatase Nat Commun. 2017 3:27943-27952
Fei Zhang, Xiaoqiang Qi, Xiaoxiao Wang, Diyang Wei, Jiawei Wu, Lingling Feng, Haiyan Cai, Yugang Wang, Naiyan Zeng, Ting Xu, Aiwu Zhou （通讯作者）, Ying Zheng Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab Oncotarget 2017 8:90215-90224
Hudie Wei,Haiyan Cai,Yuhao Ji,Pilin Wang,Qingqing Zhang, Yihui Lin,Weixiao Wang, Jinke Cheng, Naiyan Zeng, Ting Xu, Aiwu Zhou （通讯作者） Structural basis of a novel heterodimeric Fc for bispecific antibody production Oncotarget 2017 8:27943-27952
Zhang F, Wei H, Wang X, Bai Y, Wang P, Wu J, Jiang X, Wang Y, Cai H, Xu T,Zhou A. （通讯作者） Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade. Cell Discov. 2017 3:27943-27952
Huang X, Zheng Y, Zhang F, Wei Z, Wang Y, Carrell RW, Read RJ, Chen GQ, Zhou A. （通讯作者） Molecular Mechanism of Z α1-antitrypsin Deficiency. J Biol Chem. 2016 22;291(30):15674-86
Wei H, Cai H, Wu J, Wei Z, Zhang F, Huang X, Ma L, Feng L, Zhang R, Wang Y, Ragg H, Zheng Y, Zhou A. （通讯作者） Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism. J Biol Chem. 2016 291(48):24900-24911.
Yang K, Wang M, Zhao Y, Sun X, Yang Y, Li X, Zhou A, Chu H, Zhou H, Xu J, Wu M, Yang J, Yi J. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nat Commun. 2016 7:13599.
Wang Y, Wang Y, Zhang H, Gao Y, Huang C, Zhou A, Zhou Y, Li Y. Sequential posttranslational modifications regulate PKC degradation. Mol Biol Cell. 2016 27(2):410-20.
Huang X, Zhou J, Zhou A, Olson ST. Thermodynamic and kinetic characterization of the protein Z-dependent protease inhibitor (ZPI)-protein Z interaction reveals an unexpected role for ZPI Lys-239 J Biol Chem. 2015 290(15):9906-18
Wang Y, Wang Y, Zhang H, Gao Y, Huang C, Zhou A, Zhou Y, Li Y. Sequential Posttranslational Modifications Regulate PKC Degradation. Mol Biol Cell. 2015 mbc.E15-09-0624
Su Y, Al-Lamki RS, Blake-Palmer KG, Best A, Golder ZJ, Zhou A, Karet Frankl FE. Physical and functional links between anion exchanger-1 and sodium pump. J Am Soc Nephrol. 2015 26(2):400-9
Lin F, Zhou A, Wei Z. Crystallization and crystallographic studies of kallistatin. Acta Crystallogr F Struct Biol Commun. 2015 71(Pt 9):1135-8
Liu F, Zhou Q, Zhou J, Sun H, Wang Y, Zou X, Feng L, Hou Z, Zhou A, Zhou Y, Li Y. 14-3-3τ promotes surface expression of Cav2.2 (α1B) Ca2+ channels. J Biol Chem. 2015 290(5):2689-98
Qi X, Chan WL, Read RJ, Zhou A, Carrell RW. Temperature-responsive release of thyroxine and its environmental adaptation in Australians. Proc Biol Sci. 2014 281(1779):**
Chen J, Xu H, Zou X, Wang J, Zhu Y, Chen H, Shen B, Deng X, Zhou A, Chin YE,Rauscher FJ 3rd, Peng C, Hou Z. Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells. Cancer Res. 2014 74(16):4353-63
Zhao Y, Zhang X, Chen Y, Lu S, Peng Y, Wang X, Guo C, Zhou A, Zhang J, Luo Y, Shen Q, Ding J, Meng L, Zhang J. Crystal Structures of PI3Kα Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett. 2014 5(2):138-42
Li J, Xu Y, Long XD, Wang W, Jiao HK, Mei Z, Yin QQ, Ma LN, Zhou A, Wang LS, Yao M, Xia Q, Chen GQ. Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity. CANCER CELL 2014 25(1):118-31
Chan WL, Zhou A, Read RJ. Towards engineering hormone-binding globulins as drug delivery agents. PLoS One 2014 9(11)
Chan WL, Carrell RW, Zhou A, Read RJ How changes in affinity of corticosteroid-binding globulin modulate free cortisol concentration. J Clin Endocrinol Metab. 2013 98(8):3315-22
Huang X, Yan Y, Tu Y, Gatti J, *Broze GJ Jr, *Zhou A （通讯作者）,*Olson ST Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z. BLOOD 2012 23;120(8):1726-33
Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ, Zhao Q, Zhou A, Wang LS, Sun HD, Chen GQ. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nat Chem Biol. 2012 8;8(5): 486-93.
Carrell R, Qi X, Zhou A. Serpins as hormone carriers: modulation of release. Methods Enzymol. 2011 501:89-103
Read RJ, Zhou A, Stein PE. Solving serpin crystal structures. Methods Enzymol. 2011 501:49-61
Su Y, Blake-Palmer KG, Fry AC, Best A, Brown AC, Hiemstra TF, Horita S, Zhou A, Toye AM, Karet FE. Glyceraldehyde 3-phosphate dehydrogenase is required for band 3 (anion exchanger 1) membrane residency in the mammalian kidney Am J Physiol Renal Physiol. 2011 300(1):F157-66
X Qi, F Loiseau, W Chan, Y Yan, Z Wei, L Milroy, R Myers, S V Ley, R J Read, R W Carrell, *Zhou A. （通讯作者） Allosteric modulation of hormone release from thyroxine and corticosteroid binding-globulins. J. Biol. Chem. 2011 18, 16163-16173.
Cameron A, Henley D, Carrell R, Zhou A, Clarke A, Lightman S. Temperature-responsive release of cortisol from its binding globulin: a protein thermocouple J Clin Endocrinol Metab. 2010 95(10):4689-95.
*Zhou A （通讯作者）,*Carrell R.W, Murphy M.P., Wei Z, Yan Y,Stanley P. L D, Stein P.E, Broughton P.F, Read R J. A redox switch in angiotensinogen modulates angiotensin release. NATURE 2010 468(7320):108-11
Wei Z, Yan Y, Carrell RW, *Zhou A. （通讯作者） Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X. BLOOD 2009 22; 114(17): 3662-7.
*Zhou A （通讯作者）, Wei Z, Read RJ, Carrell RW. Structural mechanism for the carriage and release of thyroxine in the blood. Proc Natl Acad Sci U S A. 2006 103(36): 13321-6