导师姓名： 王颖 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 地址：重庆南路280号5号楼1208电话：**-776319
邮编： 200025 邮箱地址： ywang@sibs.ac.cn

研究方向 (点击浏览详细信息)
免疫调控异常与疾病

社会任职
上海医学会结核病学专科分会委员
上海市免疫学会第十届理事会肿瘤免疫专业委员会委员
上海市免疫学学会第十二届理事会 副理事长/青年工作委员会主任
中国医疗保健国际交流促进会结核病防治分会第一届委员会委员
中国免疫学会第八届理事会理事

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 可注射水凝胶微球治疗卒中的免疫兼容性机制研究 国家自然科学基金委重点项目 2020-01~2024-12 97万元 课题参与人
** 标志物指导下的肺癌免疫治疗人群选择策略的前瞻性研究 上海市科学技术委员会临床重点项目 2019-09~2022-06 50万元 子课题负责人
** 结核抗原特异性免疫记忆T细胞功能的代谢调控机制及其临床意义 国家自然科学基金面上项目 2019-01~2022-12 56万元 课题负责人
18XD** 抗结核免疫记忆应答调控新机制与新型疫苗设计策略 上海市科委优秀学术带头人计划 2018-05~2021-05 40万元 课题负责人
2016YFC** 基于组学特征的肺癌免疫治疗疗效预测指标的构建和验证 科技部“重大慢性非传染性疾病防控研究”重点专项 2017-09~2020-12 127万元 课题参与人
2017ZX**-001-004 结核新疫苗的免疫学特征研究 “艾滋病和病毒性肝炎等重大传染病防治”科技重大专项 2017-09~2020-12 121万元 子课题负责人
** 系统性红斑狼疮中T/B细胞黏附动力学特性及其对病理性抗体产生的作用机制探讨 国家自然基金面上项目 2014-01~2017-12 80万元 课题负责人
13ZZ083 dCTP焦磷酸酶参与肿瘤核酸代谢和细胞学行为异常的分子机制研究 科研创新（重点） 2013-01~2015-12 16万元 课题负责人
2013ZX**-003-0 8.结核分枝杆菌潜伏感染的免疫学特征及特异性防治策略（潜伏感染创新性疫苗）的研究 卫生部 2013-01~20115-12 76万元 主要责任人
** I 型干扰素调节T 细胞免疫功能的新机制及其在系统性红斑狼疮中的作用 国家自然科学基金项目 2012-01~2015-12 50万元 课题负责人
TLRs调节系统性红斑狼疮中T细胞功能的可视化研究 上海市科委国际合作项目 2010-04~2012-03 15万元 课题负责人
** T细胞受体（TCR）介导的胞内信号对T细胞免疫自稳的负向调节作用和T细胞分化影响的分子机制研究 国家自然基金委,面上项目 2008-01~2010-12 35万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Khanniche A, Zhou L, Jiang B, Song J, Jin Y, Yin J, Wang S, Ji P, Shen H, Wang Y* （通讯作者）, Xu H*. Restored and enhanced memory T cell immunity in Rheumatoid Arthritis after TNFa blocker treatment. Front Immunol 2019 10:887
Xia LL#, Liu YY#, Wang Y*. （通讯作者） PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions. The Oncologist 2019 24(Specical Issue):S31-S41
Jin Y*, Dong H*, Xia LL, Yang Y, Zhu Y, Shen Y, Zheng H, Yao C, Wang Y, Lu S*. The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti-Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC. J Thorac Oncol 2019 14(8):1378-1389.
Zhang MY, Xia LL, Yang Y, Liu S, Ji P, Wang SJ, Chen YY, Liu ZD, Zhang YY, Lu S, Wang Y* （通讯作者） PD-1 blockade augments humoral immunity through ICOS-mediated CD4+ T cell instruction. Int Immunopharmacol 2019 66:127-138
Chen YY#, Xiao JN#, Li Y#, Xiao YJ#, Xiong YQ, Liu Y, Wang SJ, Ji P, Zhao GP, Shen H, Lu SH, Fan XY*, Wang Y* （通讯作者） Mycobacterial lipoprotein Z triggers efficient innate and adaptive immunity for protection against Mycobacterium tuberculosis infection Front Immunol 2019 9:3190
Zhang MY#, Yao CC#, Cai J#, Liu S, Liu XN, Chen YY, Wang SJ, Ji P, Pan M, Kang ZJ*, Wang Y* （通讯作者） LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production Journal of Translational Medicine 2019 17(1):37
Liu YY#, Sha W#, Xu SQ, Gui XW, Xia LL, Ji P, Wang SJ, Zhao GP, Zhang X*, Chen YY*, Wang Y Identification of HLA-A2-restricted mycobacterial lipoprotein Z peptides recognized by T Cells from patients with active tuberculosis infection. Front Microbiol 2018 9:3131
Li W#, Zhang X#, Yang Y, Yin Q, Wang Y, Li Y, Wang C, Wong SM, Wang Y, Goldfine H, Akerley BJ, Shen H. Recognition of conserved antigens by Th17 cells provides broad protection against pulmonary Haemophilus influenzae infection. Proc Natl Acad Sci U S A. 2018 115(30):E7149-E7157
Xiao JN#, XiongYQ#, Chen YY#, Xiao YJ, Ji P, Li Y, Wang SJ, Zhao GP, Cheng QJ, Lu SH*, Wang Y* （通讯作者） Determination of Lipoprotein Z-specific IgA in tuberculosis and latent tuberculosis infection. Front Cell Infect Mcrobiol 2017 7:495
Zhang R, Wu X, Xia X, Khanniche A, Song F, Zhang B*, Wang Y* （通讯作者）, Ge H* OVA12 promotes tumor growth by regulating p53 expression in human cancer cells. Oncotarget 2017 8(32):52854-52865
Liu Z, Zeng W, Huang X, Wang S, Zheng J, Pan M, Wang Y* （通讯作者） Peripheral CD19hi B cells exhibit activated phenotype and functionality in promoting IgG and IgM production in human autoimmune diseases. Sci Rep 2017 7(1):13921
Yang XY#, Wu JB#, Liu Y, Xiong Y, Ji P, Wang SJ, Chen YY, Zhao GP, Lu SH, Wang Y* （通讯作者） Identification of mycobacterial bacterioferritin B for immune screening of tuberculosis and latent tuberculosis infection. Tuberculosis (Edinb) 2017 107:119-125
Yang C#, Khanniche A#, DiSpirito JR, Ji P, Wang S, Wang Y* （通讯作者）, Shen H* Transcriptome Signatures Reveal Rapid Induction of Immune-Responsive Genes in Human Memory CD8(+) T Cells. Sci Rep. 2016 6:27005
Ji P#, Zhang Y#, Wang SJ, Ge HL, Zhao GP, Xu YC, Wang Y*. （通讯作者） CD44hiCD24lo mammosphere-forming cells from primary breast cancer display resistance to multiple chemotherapeutic drugs. Oncol Rep. 2016 35(6):3293-302
Xiao YJ#, Sha W#, Tian ZF#, Chen YY, Ji P, Sun Q, Wang HY, Wang SJ, Fang Y, Wen HL, Zhao HM, Lu J, Xiao HP, Fan XY*, Shen H*, Wang Y* （通讯作者） Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis. J Mol Med 2016 94(7):823-34
Lin X, Liang Q, Lin L, Ding Q, Wang X, Wang Y*. （通讯作者） Identification of anti-moesin antibodies in the serums of patients with antiphospholipid syndrome. Thromb Res. 2015 135: 867-878
Ni C#, Chen YH#, Zeng MS#, Pei RJ, Du Y, Tang LQ, Wang MY, Hu YJ, Zhu HY, He MF, Wei XW, Wang S, Ning XK, Wang MN, Wang JF, Ma L,Chen XW, Sun Q, Tang H, Wang Y* （通讯作者）, Wang XN*. In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures Cell Research 2015 25(7):785-800
Xu J, Wu B, Wang JH, Huang L, Wang DY, Zhao L, Zhao GP, Wang Y*. （通讯作者） Pre-existing mutations in reverse transcriptase of hepatitis B virus in treatment-naive chinese patients with chronic hepatitis B. Plos One 2015 10(3): e**.
Song FF#, Xia LL#, Ji P#, Tang YB, Huang ZM, Zhu L, Zhang J, Wang JQ, Zhao GP, Ge HL, Zhang Y*, Wang Y*. （通讯作者） Human dCTP Pyrophosphatase 1 promotes breast cancer cell growth and stemness through modulation on 5-methyl-dCTP metabolism and global hypomethylation. Oncogenesis 2015 Jun 15;4:e159
Wang S, Zhang Y, Saas P, Wang H, Xu Y, Chen K, Zhong J, Yuan Y, Wang Y* （通讯作者）, Sun Y* Oridonin exerts therapeutic effect by suppressing Th1/Th17 simultaneously in a mouse model of Crohn's disease. J Gastroenterol Hepatol. 2015 30: 504-512
Fan J, Zhang Y, Xiong H*, Wang Y* （通讯作者）, Guo X. Nucleotide analog-resistant mutations in hepatitis B viral genomes found in hepatitis B patients. J Gen Virol. 2015 96(Pt 3):663-70.
Xiong FF, Xia LL, Wang JF, Wu B, Wang DY, Yuan LF, Cheng YT, Zhu HY, Che XY, Zhang QH, Zhao GP, Wang Y*. （通讯作者） A High-affinity CDR-grafted Antibody against Influenza A H5N1 Viruses Recognizes a Conserved Epitope of H5 Hemagglutinin. PLoS One. 2014 e88777
Zhang F, Zhou X, DiSpirito JR, Wang C, Wang Y, Shen H Epigenetic manipulation restores functions of defective CD8(+) T cells from chronic viral infection. Mol Ther. 2014 22(9):1698-706
Zeng W, Wang Y, Liu Z, Khanniche A, Hu Q, Feng Y, Ye W, Yang J, Wang S, Zhou L, Shen H*, Wang Y*. Long-term exposure to decabrominated diphenyl ether impairs CD8 T-cell function in adult mice. Cell Mol Immunol. 2014 11(4):367-76
Wang Y* and Wang XN*. （通讯作者） Cell-in-cell: A virgin land of cell biology OncoImmunology 2013 2(10): e25988
Chen YH, Wang S, He MF, Wang Y, Zhao H, Zhu HY, Yu XM, Ma J, Che XJ, Wang JF, Wang Y* （通讯作者）, Wang XN*. Prevalence of Heterotypic Tumor/Immune Cell-In-Cell Structure In Vitro and In Vivo Leading to Formation of Aneuploidy. PLoS One. 2013 8(3): e59418-0
He MF, Wang S, Wang Y* （通讯作者）, Wang XN*. Modeling cell-in-cell structure into its biological significance. Cell Death &Disease 2013 4, e630
Zhang Y, Ye WY, Wang JQ, Wang SJ, Ji P, Zhou GY, Zhao GP, Ge HL, Wang Y*. （通讯作者） dCTP Pyrophosphohydrase Exhibits Nucleic Accumulation in Multiple Carcinomas Eur J Histochemistry 2013 57 e29: 185-191
Wang S, He MF, Chen YH, Wang MY, Yu XM, Bai J, Zhu HY, Wang YY, Zhao H, Mei Q, Nie J, Ma J, Wang JF, Wen Q, Ma L, Wang Y* （通讯作者）, Wang XN*. Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells Cell Death &Disease 2013 4:e856
Ouyang S, Gong B, Li JZ, Zhao LX, Wu W, Zhang FS, Sun L, Wang SJ, Pan M, Li C, Liang W, Shaw N, Zheng J, Zhao GP, Wang Y （通讯作者）, Liu ZJ, Liang M Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus J Mol Med (Berl) 2012 90(7):837-46
He M, Wang Y, Shi WJ, Wang SJ, Sha HF, Feng JX, Wang J Immunomodulation of inducible co-stimulator (ICOS) in human cytokine-induced killer cells against cholangiocarcinoma through ICOS/ICOS ligand interaction J Dig Dis 2011 12(5):393-400
Mingueneau M, Roncagalli R, Gregoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity 2009 31(2):197-208
Jin S, Wang Y （通讯作者）, Zhang Y, Zhang HZ, Wang SJ, Tang JQ, Chen HJ, Ge HL Humoral immune responses against tumor-associated antigen OVA66 originally defined by serological analysis of recombinant cDNA expression libraries and its potentiality in cellular immunity Cancer Sci 2008 99(8):1670-8
Wang Y, Kissenpfennig A, Mingueneau M, Richelme S, Perrin P, Chevrier S, Genton C, Lucas B, DiSanto JP, Acha-Orbea H, Malissen B, Malissen M Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells J Immunol 2008 180(3):1565-75
Gregoire C, Simova S, Wang Y, Sansoni A, Richelme S, Schmidt-Giese A, Simeoni L, Angelisova P, Reinhold D, Schraven B, Horejsi V, Malissen B, Malissen M Deletion of the LIME adaptor protein minimally affects T and B cell development and function Eur J Immunol 2007 37(11):3259-69