导师姓名： 黄功华 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市重庆南路280号西5号楼1207室
邮编： 200025 邮箱地址： gonghuahuang@yahoo.com

研究方向 (点击浏览详细信息)
免疫调控，自身免疫病

社会任职
中国免疫学会会员
美国关节炎研究基金会研究****
中国研究型医院学会过敏医学专业委员会委员，青年副主委
美国免疫学会会员
American Journal of Gastroenterology、Journal of Molecular Medicine、Cancer Letters、Cellular & Molecular Immunology、Cancer、Journal of Translational Medicine等杂志审稿人

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2018YFC** 超声空化生物学效应评价的关键技术研究（数字诊疗装备研发） 国家重点研发计划 2018-07~2020-12 80万元 课题参与人
** 细胞类型特异性p38α信号通路在调节Th17细胞分化及银屑病发病中的作用研究 国家自然科学基金面上项目 2017-01~2020-12 60万元 课题负责人
** 树突状细胞p38α信号通路在维持肠道免疫稳态及肠炎和肠炎相关结肠癌发生发展中的机制研究 国家自然科学基金重大研究计划培育项目 2017-01~2019-12 60万元 课题负责人
** p38α/MKP-1信号轴在调控Th17细胞分化及自身免疫性关节炎中的作用研究 国家自然科学基金面上项目 2015-01~2018-12 71万元 课题负责人
2014CB541800 强直性脊柱炎发生机制及控制策略研究 国家重点基础研究计划（973）项目 2014-01~2018-12 150万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Luo Y, Xue Y, Wang J, Dang J, Fang Q, Huang G, Olsen N, Zheng SG Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells Cell Rep 2019 26(7):1869-1879.e3
Li Y,Guo X, Hu C, Du Y, Guo C, Wang D, Zhao W, Huang G, Li C, Lu Q, Lai R, Tao Xu T, and Qi X Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection Cell Death Differ 2018 s41418-017-0041-z
Zhao W, Xiao S, Li H, Zheng T, Huang J, Hu R, Zhang B, Liu X, Huang G （通讯作者） MAPK Phosphatase-1 Deficiency Exacerbates the Severity of Imiquimod-Induced Psoriasiform Skin Disease Front Immunol 2018 9:569
Zheng T, Zhao W, Li H, Xiao S, Hu R, Han M, Liu H, Liu Y, Otsy K, Liu X, Huang G （通讯作者） p38a signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation Sci Signal 2018 11: eaao 1685
Han M, Hu R, Ma J, Zhang B, Chen C, Li H, Yang J, Huang G （通讯作者） Fas signalling in Dendritic cells mediates Th2 polarization in HDM-induced allergic pulmonary inflammation Front Immunol 2018 9:3045.
Zheng T, Zhang B, Chen C, Ma J, Meng D, Huang J, Han M, Hu R, Liu X, Otsu K, Liu A, Li H, Yin Z, Huang G （通讯作者） Protein kinase p38a in dendritic cells regulates colon inflammation and tumorigenesis Proc Natl Acad Sci U S A 2018 pnas.
Shi P, Zhang M, Yang W, Zhang L, Wang K, Zhang J, Otsu K, Huang G （通讯作者）, Fan X, Liu J Platelet-specific p38a deficiency improved cardiac function after myocardial infarction in mice Arterioscler Thromb Vasc Biol 2017 ATVBAHA.117.309856
Huang G, Wang Y, Vogel P, Chi H Control of IL-17 receptor signaling and tissue inflammation by the p38a/MKP-1 signaling axis Sci Signal 2015 8(366):ra24
Huang G, Wang Y, Chi H Control of T cell fates and immune tolerance by p38α signaling in mucosal CD103+ dendritic cells J Immunol 2013 191(2):650-9
Wang Y, Huang G, Zeng H, Yang K, Lamb RF, Chi H Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells Proc Natl Acad Sci U S A 2013 110(50):E4849-903
Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection Nat Immunol 2013 14(5):480-8
Huang G, Wang Y, Vogel P, Kanneganti TD, Otsu K, Chi H Signaling via the kinase p38? programs dendritic cells to drive TH17 differentiation and autoimmune inflammation Nat Immunol 2012 13(2):152-61
Huang G, Wang Y, Chi H Regulation of TH17 cell differentiation by innate immune signals Cell & Mol Immunol 2012 9(4):287-95
Wang Y, Huang G （共同第一作者）, Vogel P, Neale G, Reizis B, Chi H TAK1-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function Proc Natl Acad Sci U S A 2012 109(6):E343-52
Huang G, Wang Y, Shi LZ, Kanneganti TD, Chi H Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates Immunity 2011 35(1):45-58
Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H HIF1?-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells J Exp Med 2011 208(7):1367-76
Han Y, Huang G （共同第一作者）, Zhang Q, Yuan S, Liu J, Zheng T, Fan L, Chen S, Xu A The primitive immune system of amphioxus provides insights into the ancestral structure of the vertebrate immune system Dev Comp Immunol 2010 34(8):791-6
Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR Nat Immunol 2009 10(7):769-77
Huang G, Shi LZ, Chi H. Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination Cytokine 2009 48(3):161-9
Huang G, Xie X, Han Y, Fan L, Chen J, Mou C, Guo L, Liu H, Zhang Q, Chen S, Dong M, Liu J, Xu A The identification of lymphocyte-like cells and lymphoid-related genes in amphioxus indicates the twilight for the emergence of adaptive immune system PLoS One 2007 2(2):e206
Huang G, Liu H, Han Y, Fan L, Zhang Q, Liu J, Yu X, Zhang L, Chen S, Dong M, Wang L, Xu A Profile of acute immune response in Chinese amphioxus upon Staphylococcus aureus and Vibrio parahaemolyticus infection Dev Comp Immunol 2007 31(10):1013-23