导师姓名： 刘智多 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： -776749
邮编： 200025 邮箱地址： zhiduo.liu@shsmu.edu.cn

研究方向 (点击浏览详细信息)
免疫反应微环境

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** CCR4控制调节性T细胞的空间分布及其对自身免疫性疾病的作用 国家自然科学基金委员会 2019-01~2022-12 60万元 课题负责人
海外高层次人才项目 上海市教育委员会 2017-09~2020-08 100万元 课题负责人
17PJ** 骨髓中免疫前体细胞发育的微环境 上海市科学技术委员会 2017-07~2019-06 20万元 课题负责人
17ZR** 骨髓里记忆性T细胞所处的微环境的研究 上海市科学技术委员会 2017-05~2020-04 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z*, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C, Yi J, Zou Q. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nature Communications. 2018 9(1):3157-3167.
Yu X, Teng XL, Wang F, Zheng Y, Qu G, Zhou Y, Hu Z, Wu Z, Chang Y, Chen L, Li HB, Su B, Lu L, Liu Z* （通讯作者）, Sun SC, Zou Q. Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. Journal of Experimental Medicine. 2018 215(9):2463-2476.
Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z*, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O. A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System. Immunity. 2017 46(4):609-620.
Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z*, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN. Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells. Journal of Immunology. 2017 198(2):895-907.
Liu Z*, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN. Immune homeostasis enforced by co-localized effector and regulatory T cells. Nature. 2015 528(7581):225-30.
Lo B, Zhang K, Lu W, Zheng L, Zhang Q, Kanellopoulou C, Zhang Y, Liu Z*, Fritz JM, Marsh R, Husami A, Kissell D, Nortman S, Chaturvedi V, Haines H, Young LR, Mo J, Filipovich AH, Bleesing JJ, Mustillo P, Stephens M, Rueda CM, Chougnet CA, Hoebe K, McElwee J, Hughes JD, Karakoc-Aydiner E, Matthews HF, Price S, Su HC, Rao VK, Lenardo MJ, Jordan MB. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science. 2015 349(6246):436-40.
Li Z, Zhang Y, Liu Z*, Wu X, Zheng Y, Tao Z, Mao K, Wang J, Lin G, Tian L, Ji Y, Qin M, Sun S, Zhu X, Sun B. ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nature Immunology. 2011 12(2):178-85.
Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z*, Nurieva R, Liu X, Chung Y, Chang SH, Sun B, Dong C. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nature Immunology. 2009 10(12):1260-6.
Bi E, Huang C, Hu Y, Wu X, Deng W, Lin G, Liu Z*, Tian L, Sun S, Mao K, Zou J, Zheng Y, Sun B. Novel function of perforin in negatively regulating CD4(+) T cell activation by affecting calcium signaling. Cell Research. 2009 19(7):816-27.
Liu Z# （共同第一作者）,, Li Z#, Mao K, Zou J, Wang Y, Tao Z, Lin G, Tian L, Ji Y, Wu X, Zhu X, Sun S, Chen W, Xiang C, Sun B. Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling. Journal of Immunology. 2009 183(10):6320-9.
Xie D#, Li Z# （共同第一作者）, Li Z, Ji Y, Chen J, Sun B. Differential expression of neutrophilic granule proteins between Th1 and Th2 cells. Acta Biochimica et Biophysica Sinica. 2007 39(1):67-72.