导师姓名： 丁健青 专业代码： 100204
性别： 男 专业名称： 神经病学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： jqding18@yahoo.com

研究方向 (点击浏览详细信息)
神经退行性疾病的分子发病机制

社会任职
中华医学会神经病学分会神经生化学组委员
上海市神经科学学会第八届理事会常务理事、秘书长
上海医学会神经内科分会神经生化、免疫、遗传学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** miR-4639-5p的表达调控及其异常在帕金森病发病中作用的研究 国家自然科学基金面上项目 2019-01~2022-01 56万元 课题负责人
** PD小胶质细胞中突变型α-synuclein异常积聚的分子机制研究 国家自然科学基金，重点项目 2017-01~2021-12 275万元 课题负责人
2016YFC** 遗传、环境、老化因素及其之间的交互作用 科技部国家重点研发计划 2016-09~2020-12 235万元 课题负责人
14XD** 突变型alpha-synuclein 细胞内转运途径异常与帕金森病发病关系的关系 上海市科委，优秀学术带头人 2014-07~2017-06 40万元 课题负责人
** CD200R表达调控异常在小胶质细胞激活及帕金森病发病中作用的研究 国家自然科学基金，面上项目 2014-01~2017-12 75万元 课题负责人
13JC** NGF信号内体运输异常在阿尔茨海默病发病中作用及可能机制的研究 上海市科委“科技创新行动计划”基础重点项目 2013-09~2016-08 40万元 课题负责人
** 阿尔茨海默病和糖尿病周围神经病变潜在治疗药物NGF R100M knock-in小鼠的制备及生物学特性分析 上海市科委，实验动物专项 2013-07~2015-11 25万元 课题负责人
12ZZ115 NGF/TrkA信号逆向运输异常与阿尔茨海默病发病关系的研究 上海市教委,重点项目 2012-01~2014-12 16万元 课题负责人
** Aβ异常增加致NGF/TrkA信号逆向运输受损的分子机制的研究 国家自然基金委,面上项目 2012-01~2015-12 60万元 课题负责人
2012BAI10B03 神经退行性疾病防控研究 国家科技部“十二五科技支撑计划” 2012-01~2015-12 451万元 课题负责人
08PJ** 积聚的MAP8对轴突逆向运输的影响及在阿尔茨海默病发病中的作用 上海市科委,浦江人才 2008-07~2010-07 30万元 课题负责人
** 微管相关蛋白8在轴突逆向运输及巨轴突神经变性病致病中的作用 国家自然基金委,面上项目 2008-01~2010-12 30万元 课题负责人
2007CB947900 胚胎干细胞定向分化过程中关键科学问题的研究 国家科技部 2007-9~2011-12 98万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Ruinan Shen,Suzhen Lin,Lu He,Xue Zhu, Zhekun Zhou, Shengdi Chen,Ying Wang,Jianqing Ding （通讯作者） Association of Two Polymorphisms in CCL2 With Parkinson's Disease: A Case-Control Study Front Neurol 2019 2019; 10: 35.
Lu He, Suzhen Lin,Hong Pan,Ruinan Shen,Mengyan Wang,Zhihao Liu,Shiyao Sun,Yuyan Tan,Ying Wang,Shengdi Chen,and Jianqing Ding （通讯作者） Lack of Association Between DJ-1 Gene Promoter Polymorphism and the Risk of Parkinson’s Disease Front Aging Neurosci 2019 2019:11-24
Wanlin Yang, Kijung Sung, Fengli Zhou, Wei Xu, Robert A Rissman, Jianqing Ding （通讯作者）, Chengbiao Wu Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System Frontiers in Aging Neuroscience 2018 10: 373
Fangfang Dou, Xinkun Chu, Bei Zhang, Liang Liang, Guoqiang Lu, Jianqing Ding （通讯作者）, Shengdi Chen EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-κB signaling pathway Molecular Brain 2018 11: 75
Yimeng Chen, Chao Gao, Qian Sun, Hong Pan, Pei Huang, Jianqing Ding （通讯作者）, Shengdi Chen MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson’s Disease Frontiers in Aging Neuroscience 2017 9: 232
Fang Fang, Wanlin Yang, Jazmin B. Florio, Edward Rockenstein, Brian Spencer, Xavier M. Orain, Stephanie X. Dong, Huayan Li, Xuqiao Chen, Kijung Sung, Robert A. Rissman, Eliezer Masliah, Jianqing Ding （通讯作者）,Chengbiao Wu. Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease Scientific Reports 2017 7: 3868
Xiaodong Yang, Yue Lou, Guidong Liu, Xueping Wang, Yiwei Qian, Jianqing Ding （通讯作者）, Shengdi Chen, Qin Xiao. Microglia P2Y6 receptor is related to Parkinson’s disease through neuroinflammatory process Journal of Neuroinflammation 2017 14: 38
Wei Xu, April M. Weissmiller, Joseph A. White, Fang Fang, Xinyi Wang, Yiwen Wu, Matthew L. Pearn, Xiaobei Zhao, Mariko Sawa, Shengdi Chen, Shermali Gunawardena, Jianqing Ding （通讯作者）, William C. Mobley and Chengbiao Wu Amyloid precursor protein–mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration The Journal of Clinical Investigation 2016 126(5): 1815–1833
Yi Ren,Min Ye, Shengdi Chen, Jianqing Ding （通讯作者） CD200 Inhibits Inflammatory Response by Promoting KATP Channel Opening in Microglia Cells in Parkinson's Disease. MEDICAL SCIENCE MONITOR 2016 22: 1733–1741
Ying Wang, Ying Wang, Yi Sui, Hongshuang Yu, Xiaoheng Shen, Shengdi Chen, Gang Pei, Jian Zhao, Jianqing Ding （通讯作者） The combination of aricept with a traditional Chinese medicine formula, smart soup, may be a novel way to treat Alzheimer's disease. Journal of Alzheimer's Disease 2015 45(4):1185-1195
Xiong R, Wang Z, Zhao Z, Li H, Chen W, Zhang B, Wang L, Wu L, Li W, Ding J （通讯作者）, Chen S. MicroRNA-494 reduces DJ-1 expression and exacerbates neurodegeneration Neurobiology of Aging 2014 35(3):705-714
Xu W, Xu J, Wang Y, Tang H, Deng Y, Ren R, Wang G, Niu W, Ma J, Wu Y, Zheng J, Chen S, Ding J. （通讯作者） The genetic variation of SORCS1 is associated with late-onset Alzheimer's disease in Chinese Han population PLoS One 2013 8(5):-
Lipeng Tian , Shi Zhang , Liang Xu, Wen Li, Ying Wang, Shengdi Chen, Jianqing Ding （通讯作者） Selenite benefits embryonic stem cells therapy in Parkinson's disease Current Molecular Medicine 2012 12(8):1005-14
Lipeng Tian, Shi Zhang, Yingjie Zhang, Jianqing Ding （通讯作者）, Shengdi Chen Lmx1b can promote the differentiation of embryonic stem cells to dopaminergic neurons associated with Parkinson's disease. Biotechnology Letters 2012 34(7):1167-74
Shi Zhang, Xijin Wang, Lipeng Tian, Jing Pan, Guoqiang Lu, Yingjie Zhang, Jianqing Ding （通讯作者）, Shengdi Chen CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease Journal of Neuroinflammation 2011
Yiwen Wu, Tianyi Rong, Huahua Li, Qing Xiao, Qingzhou Fei, Eng-King Tan, Jianqing Ding （通讯作者）, Shengdi Chen Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians Acta Neurologica Scandinavica 2011 124(4):264-268
Zhiquan Wang, Jun Liu, Shiyan Chen, ying Wang, Li Cao, Yu Zhang, Wenyan Kang, Hui Li, Yaxing Gui, Shengdi Chen, Jianqing Ding （通讯作者） Park7/DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the ERK1/2-Elk-1 pathway in neuroprotection Annals of Neurology 2011 70(4):591-599
Zhiquan Wang, Yu Zhang, Shi Zhang, Qianqian Guo, Yuyan Tan, Xinyi Wang, Ran Xiong, Jianqing Ding （通讯作者）, Shengdi Chen DJ-1 can inhibit microtubule associated protein 1 B formed aggregates Molecular Neurodegeneration 2011
Peijing Cui, Lan Zheng, Li Cao, Ying Wang, Yulan Deng, Gang Wang, Wei Xu, Huidong Tang, Jianfang Ma, Ting Zhang, Jianqing Ding （通讯作者）, Qi Cheng, Shengdi Chen CALHM1 P86L Polymorphism is a Risk Factor for Alzheimer's Disease in the Chinese Population Journal of Alzheimers Disease 2010 19(1):31-5
Hongmei Wang, Yanxing Zhao, Shi Zhang, Guidong Liu, Wenyan Kang, Huidong Tang, Jianqing Ding （通讯作者）, Shengdi Chen PPARγ agonist curcumin reduces the β- amyloid- stimulated inflammatory responses in primary astrocytes Journal of Alzheimers Disease 2010 20(4):1189-1199
Jianfang Ma, Hongmei Wang, Qingyun Li, Yu Zhang, Jing Pan, Qiang Qiang, Xiaoyu Xin, Huidong Tang, Jianqing Ding （通讯作者）, Sheng-Di Chen Starvation triggers Aβ42 generation from human umbilical vascular endothelial cells FEBS Letters 2010 584(14):3101-6
Xiaoguang Luo, Jijuan Zhang, Chaodong Zhang, Rong Liu, Lan Zheng, Xijin Wang, Shengdi Chen, Jianqing Ding （通讯作者） Altered Regulation of CD200 Receptor in Monocyte-Derived Macrophages from Individuals with Parkinson's Disease Neurochemical Research 2010 35(4):540-7
Hongmei Wang, Jianfang Ma, Yuyan Tan, Zhiquan Wang, Chengyu Sheng, Shengdi Chen, Jianqing Ding （通讯作者） Aβ1–42 induces ROS-mediated autophagic cell death in U87 and SH-SY5Y cells Journal of Alzheimers Disease 2010 21(2):597-610
Qingyun Li, Hongmei Wang, Zhiquan Wang, Jianfang Ma, Jianqing Ding* （通讯作者）, Sheng-Di Chen Salidroside attenuates hypoxia-induced abnormal processing of β-amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells Neuroscience Letters 2010 481(3):154-8
Li Cao, Lan Zheng, Weiguo Tang, Qin Xiao, Ting Zhang, Huidong Tang, Songbin He, Xijin Wang, Jian-Qing Ding （通讯作者）, Sheng-Di Chen Four Novel Mutations in the GCH1 Gene of Chinese Patients with Dopa-Responsive Dystonia Movement Disorders 2010 25(6):747-52
Jing Pan, Qin Xiao, Chengyu Sheng, Zhen Hong, Hongqi Yang, Gang Wang, Jianqing Ding （通讯作者）, Shengdi Chen Blockade of the translocation and activation of c-Jun N-terminal kinase 3 (JNK3) attenuates dopaminergic neuronal damage in mouse model of Parkinson's disease Neurochemistry International 2009 54(7):418-2
Wei Zhang, Jianqing Ding （共同第一作者）, Yan Qu, Hongliang Hu, Meihua Lin, Amit Datta, Alan Larson, George E. Liu,Biaoru Li Genomic expression analysis by single-cell mRNA differential display of quiescent CD8 T cells from tumour-infiltrating lymphocytes obtained from in vivo liver tumours Immunology 2009 127(1):83-90
Jing Pan, Jing Qian, Yu Zhang, Jianfang Ma, Gang Wang, Qin Xiao, Shengdi Chen, Jianqing Ding （通讯作者） Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic injury via inhibiting the JNK-signaling pathway Labatory Investigation 2009 90(2):156-67
Zhikun Sun, Hongqi Yang, Jing Pan, Zhen Hong, Zhiquan Wang, Shengdi Chen, Jianqing Ding （通讯作者） Protective effects of erythropoietin on tau phosphorylation induced by beta-amyloid Journal of Neuroscience Research 2008 86(13):3018-3027
Li Cao, Ting Zhang, Qin Xiao, Ying Wang, Li Bai, Guoqiang Lu, Jianfang Ma, Jing Zhang, Jianqing Ding （通讯作者）, Shengdi Chen The prevalence of LRRK2 Gly238AArg variant in Chinese Han population with Parkinson's disease Movement Disorders 2007 22(16):2439-2443
Jiajia Liu, Jianqing Ding （共同第一作者）, Chengbiao Wu, Prasanthi Bhagavatula, Bianxiao Cui, Steve Chu, William C. Mobley, Yanmin Yang Retrolinkin, a novel membrane protein, plays an important role in retrograde axonal transport Proceedings of the National Academy of Sciences of the United States of America 2007 104(7):2223-2228
Jianqing Ding, Angela Valle, Elizabeth Allen, Wei Wang, Timothy Nardine, Yingjiu Zhang, Lily Peng, Yanmin Yang Microtubule associated protein 8 contains two microtubule binding sites Biochemical and Biophysical Research Communications 2006 339(1):172-179
Jianqing Ding, Elizabeth Allen, Wei Wang, Angela Valle, Chengbiao Wu, Timothy Nardine, Bianxiao Cui, Jing Yi, Anne Taylor, Noo Li Jeon, Steve Chu, Yuen So, Hannes Vogel, Ravi Tolwani, William C. Mobley, Yanmin Yang Gene targeting of GAN in mouse cause a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport Human Molecular Genetics 2006 15(9):1451-1463
Elizabeth Allen, Jianqing Ding （共同第一作者）, Wei Wang, Suneet Pramanik, Jonathan Chou, Vincent Yau, Yanmin Yang Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival Nature 2005 438(7065):224-228
Jianqing Ding, Jiajia Liu, Anthony S Kowal, Timothy Nardine, Priyanka Bhattacharya, Arthur Lee, Yanmin Yang Gigaxonin-controlled degradation of Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin The Journal of Cell Biology 2002 158(3):427-433