导师姓名： 刘军 专业代码： 100204
性别： 男 专业名称： 神经病学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： jly0520@hotmail.com

研究方向 (点击浏览详细信息)
帕金森病及其他神经变性疾病的基础与临床研究

社会任职
教育部“****”****
中国神经科学学会神经退行性疾病分会常委
中华医学会老年医学分会神经病学组委员
国际运动障碍协会亚太教育委员会委员
中华医学会神经病学分会常委
上海中西医结合学会神经内分泌委员会候任主任委员
中华医学会神经病学分会帕金森及运动障碍学组委员
中国医师协会神经病学分会帕金森及运动障碍专委会委员
中国老年保健协会脑保健专委会副主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** VPS35调节α-突触核蛋白外泌体分泌的相关机制研究 国家自然科学基金 2019-01~2022-12 56万元 课题负责人
2016YFC** 帕金森病运动前期队列研究 科技部 2016-09~2020-12 117.2万元 课题负责人
** 寡聚型α-突触共核蛋白致小胶质细胞异常迁移的机制研究 国家自然科学基金（面上项目） 2015-01~2018-12 80万元 课题负责人
** LRRK2及其突变体致神经元线粒体功能失衡的机制研究 国家自然科学基金委（面海外合作项目） 2013-01~2014-12 20万元 子课题负责人
11SG20 突触共核蛋白与神经元线粒体分裂\融合关系的研究 上海市教委 2012-01-~2014-12 15万元 课题负责人
** 突变型A53T alpha-synuclein致神经元线粒体分裂/融合异常的分子机制研究 国家自然科学基金（面上项目） 2012-01~2015-12 58万元 课题负责人
** Synaptojanin-1j介导Parkin对多巴胺能神经末梢突触功能的影响 国家自然科学基金（面上项目） 2011-01~2013-12 30万元 课题负责人
09PJ** alpha-synuclein激活小胶质细胞的相关机制研究 上海市科委，浦江人才计划资助项目 2009-07~2011-07 20万元
** 突变型alpha-synuclein A53T 细胞内转运途径与小胶质细胞持续激活的关系 国家自然科学基金（面上项目） 2009-01~2011-12 28万元 课题负责人
08ZR** 小胶质细胞的异常激活在帕金森病发病中的作用 上海市科委，自然科学基金 ~2010-09 10万元

学术论文 作者论文标题期刊名出版年卷期页码
Meng-sha Yao, Li-che Zhou, Yu-yan Tan, Hong Jiang, Zhi-chun Chen, Lin Zhu, Ning-di Luo, Quan-zhou Wu, Wen-yan Kang, Jun Liu （通讯作者） Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities Aging and Diseae 2020 23;11(4):791-800
Zhichun Chen, Guanglu Li, Jun Liu （通讯作者） Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment Neurobiology of Disease 2020 134: 104700
Yuanyuan Li, Mengyue Niu, Aonan Zhao, Wenyan Kang, Zhichun Chen, Ningdi Luo, Liche Zhou, Xiongwei Zhu, Liming Lu and Jun Liu CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease Journal of Neuroinflammation 2019 16:263
Yi Liu, Xiaopin Ma, Hisashi Fujiokac, Jun Liu （通讯作者）, Shengdi Chen, Xiongwei Zhu DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1 Proceedings of the National Academy of Sciences 2019 116(50): 25322-25328
Jiang Sirui, Nandy Priya, Wang Wenzhang, Ma Xiaopin, Hsia Jeffrey, Wang Chunyu, Wang Zhenlian, Niu Mengyue, Siedlak L Sandra, Torres Sandy, Fujioka Hisashi, Xu Ying, Lee Hyoung-gon, Perry George, Liu Jun （通讯作者）, Xiongwei Zhu Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex Mol Neurodegener 2018 13(1):5
Chen ZC, Chen SD, Liu Jun （通讯作者） The role of T cells in the pathogenesis of Parkinson’s disease Prog Neurobiol 2018 169 (2018) 1-23
Li Yuanyuan, Kang WY, Yang Qi, Zhang LN, Zhang LY, Dong FY, Chen SD, Liu Jun （通讯作者） Predictive markers for early conversion of iRBD to Neurodegenerative Synucleinopathy diseases Neurology 2017 88(16):1493-1500
Zhou LP, Wang W, Hoppel C, Liu Jun （通讯作者）, Zhu XW Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits Biochim Biophys Acta 2017 1863(11):2791-2795
Qian Sun, Tian Wang, Tian-Fang Jiang, Pei Huang, Dun-Hui Li, Ying Wang, Qin Xiao, Jun Liu （通讯作者）, Sheng-Di Chen Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients Aging and disease 2016 7(5)
Wei Chen, Wen-Yan Kang, Shuai Chen, Ying Wang, Qin Xiao, Gang Wang, Jun Liu （通讯作者）, Sheng-Di Chen Hyposmia correlates with SNCA variant and non-motor symptoms in Chinese patients with Parkinson’s disease Parkinsonism and Related Disorders 2015 6;21(6):610-4
Dun-hui Li, Lin-yuan Zhang, Yun-yun Hu, Xu-feng Jiang, Hai-yan Zhou, Qiong Yang, Wen-yan Kang, Jun Liu （通讯作者）, Sheng-Di Chen Transcranial sonography of the substantia nigra and its correlation with DAT-SPECT in the diagnosis of Parkinson's disease Parkinsonism and Related Disorders 2015 8;21(8):923-8
Wenzhang Wang, Xinglong Wang, Hisashi Fujioka, Charles Hoppel, Alan L Whone, Maeve A Caldwell, Peter J Cullen, Jun Liu （通讯作者）, Xiongwei Zhu Parkinson’s disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes Nat Med 2015 30. doi: 10.1038/nm.3983
Xiao-Ying Wang,Wen-Yan Kang,Qiong Yang,Lin-Yuan Zhang,Sheng-Di Chen, Jun Liu （通讯作者） Using Gastrocnemius sEMG and Plasma a-Synuclein for the Prediction of Freezing of Gait in Parkinson’s Disease Patients PLOS ONE 2014 9(2):893-53
Wen-YanKang,QiongYang,Xu-FengJiang,WeiChen,Lin-YuanZhang, Xiao-Ying Wang,Li-Na Zhang,ThomasJ.Quinn,JunLiu （通讯作者）,Sheng-DiChen Salivary DJ-1 could be an indicator of Parkinson’s disease progression Frontiers in Aging Neuroscience 2014 6(102):1-
Hui Wu,Fangyi Dong,Ying Wang,Qin Xiao,Qiong Yang,Jing Zhao,Thomas J. Quinn,Sheng-di Chen,Jun Liu （通讯作者） Catechol-O-methyltransferase Val158Met polymorphism: Modulation of wearing-off susceptibility in a Chinese cohort of Parkinson's disease Parkinsonism and Related Disorders 2014 20():109-4
Jun Liu （共同第一作者）,Qin Xiao,Ying Wang,Zhi-Min Xu,Ying Wang,Qiong Yang,Gang Wang,Yu-Yan Tan,Jian-Fang Ma,Jin Zhang,Wei Huang,Sheng-Di Chen Analysis of Genome-wide Association Study-linked Loci in Parkinson’s Disease of Mainland China Movement Disorders 2013 28(13):189-2
Ya-Xing Gui,Xin-Yi Wang, Wen-Yan Kang, Ying-Jie Zhang, Yu Zhang, Yong Zhou,Thomas J. Quinn, Jun Liu （通讯作者）, Sheng-Di Chen Extracellular signal-regulated kinase is involved inalpha-synuclein-induced mitochondrial dynamic disorders byregulating dynamin-like protein 1 Neurobiology of Aging 2012 33：2841–2854
Bin Liu, Yu Zhang, Ying Wang, Qin Xiao, Qiong Yang, Gang Wang, Jianfang Ma, Jing Zhao, Thomas J. Quinn, Sheng-di Chen, Jun Liu （通讯作者） Angiogenin variants are not associated with Parkinson’s disease in the ethnic Chinese population Parkinsonism Relat Disord 2012 11：1–6
Wang Z, Liu J, Chen SD, Ding JQ DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection Ann Neurol 2011 70(4):591-599
Liu J （共同第一作者）, Shi M, Hong Z, Bradner J, Quinn T, Beyer RP, McGeer PL, Chen S, Zhang J. Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by alpha-synuclein Proteomics 2010 25:1-7
Hong Z, Liu J （共同第一作者）, Li Xia,Shengdi Chen. Identification of glial-cell-line-derived neurotrophic factor-regulated proteins of striatum in mouse model of Parkinson disease. Proteomics Clin Appl 2009 3:1–12.
Hong Z, Zhang QY, Liu J （共同第一作者）, Wang ZQ, Zhang Y, Xiao Q, Lu J, Zhou HY, Chen SD. Phosphoproteome study reveals Hsp27 as a novel signaling molecule involved in GDNF-induced neurite outgrowth. Journal of Proteome Research 2009 8:2768-2787.
Liu J （共同第一作者）, Zhang JP, Shi M, Quinn T, Bradner J, Beyer R, Chen S, Zhang J. Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein. J Neurosci 2009 29(5):1480-5.
Liu J （共同第一作者）,Zhen Hong,Jianqing Ding,Jianrong Liu,Jing Zhangand Shengdi Chen. Predominant Release of Lysosomal Enzymes by Newborn RatMicroglia After LPS Treatment Revealed by Proteomic Studies. Journal of proteome research 2008 (5):2033-49.
Liu J （共同第一作者）, Zhou Y, Wang Y, Fong H, Murray TM, Zhang J. Identification of Proteins Involved in Microglial Endocytosis ofalpha-Synuclein Journal of proteome research 2007 6(9):3614-3627.
Chen L, Jin J, Davis J, Zhou Y, Wang Y, Liu J, Lockhart PJ, Zhang J. Oligomeric alpha-synuclein inhibits tubulin polymerization. Biochem Biophys Res Commun 2007 356(3):548-553.
Jin J, Shie FS, Liu J, Wang Y, Davis J, Schantz AM, Montine KS, Montine TJ, Zhang J. Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein. Journal of Neuroinflammation 2007 4(4):2-2.
McLaughlin P, Zhou Y, Ma T, Liu J, Zhang W, Hong JS, Kovacs M, Zhang J. Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity. Glia 2006 53(6):567-582.