导师姓名： 孙苏亚 专业代码： 100204
性别： 女 专业名称： 神经病学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： sunsuya@shsmu.edu.cn
邮编： 邮箱地址： sunsuya@shsmu.edu.cn

研究方向 (点击浏览详细信息)
钙离子信号和神经退行性疾病

社会任职
中国老年医学学会基础与转化医学分会 委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** Neuronatin对老年认知障碍神经细胞钙稳态的调节机制 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
** EphrinB3胞内信号介导的早期阿尔茨海默病发病机制的研究 国家自然科学基金面上项目 2017-01~2020-12 60万元 课题负责人
16JC** 阿尔兹海默病研究资源库和早期诊断技术研发 上海市科委 2016-12~2019-11 50万元 子课题负责人
** PTEN对阿尔茨海默病的神经元突触钙信号异常的调节机制 国家自然科学基金面上项目 2015-01~2018-12 70万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Hualong Wang, Qiongqiong Li, Suya Sun* （通讯作者）, Shengdi Chen* Neuroprotective Effects of Salidroside in a Mouse Model of Alzheimer's Disease Cell Mol Neurobiol 2020 Jan 30
Peng-Hui Ai#, Si Chen#, Xian-Dong Liu, Xiao-Na Zhu, Yuan-Bo Pan, Dong-Fu Feng, Shengdi Chen, Nan-Jie Xu*, Suya Sun* （通讯作者） Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer's disease mice. Transl Neurodegener 2020 9(1):18
Xian-Dong Liu#, Peng-Hui Ai #, Xiao-Na Zhu, Yuan-Bo Pan , Michael M Halford , Mark Henkemeyer, Dong-Fu Feng, Tian-Le Xu, Suya Sun* （通讯作者）, Nan-Jie Xu*. Hippocampal Lnx1-NMDAR multiprotein complex mediates initial social memory. Mol Psychiatry 2019 Nov 26
Jian Dong, Yuan-Bo Pan, Xin-Rong Wu, Li-Na He, Xian-Dong Liu, Dong-Fu Feng, Tian-Le Xu, Suya Sun* （通讯作者）, and Nan-Jie Xu* A neuronal molecular switch through cell-cell contact that regulates quiescent neural stem cells Science Advances 2019 5(2): eaav4416
Xiao-Na Zhu, Xian-Dong Liu, Suya Sun* （通讯作者）, Hanyi Zhuang, Jing-Yu Yang, Mark Henkemeyer, Nan-Jie Xu*. Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behavior. Nature Communications 2016 24(7): 11096
Bei Zhang, Qiongqiong Li, Xingkun Chu, Suya Sun* （通讯作者）, Shengdi Chen* Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Drosophila model of Alzheimer’s disease Translational Neurodegeneration 2016 5: 21
Bei Zhang, Ying Wang, Hui Li, Ran Xiong, Zongbo Zhao, Xingkun Chu, Qiongqiong Li, Suya Sun* （通讯作者）, Shengdi Chen*. Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models. Drug Design, Development and Therapy 2016 10: 1335—1343
Zhang H, Liu J, Sun S, Pchitskaya E, Popugaeva E, Bezprozvanny I. Calcium signaling, excitability, and synaptic plasticity defects in mouse model of Alzheimer's disease. Journal of Alzheimer’s Disease 2015 3(7)
Suya Sun, Hua Zhang, Jie Liu, Elena Popugaeva, Nan-Jie Xu, Stefan Feske, Charles L. White III,and Ilya Bezprozvanny Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice Neuron 2014 82: 79–93
Liu J, Supnet C, Sun S （共同第一作者）, Zhang H, Good L, Popugaeva E, Bezprozvanny I. The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease. Channels (Austin). 2014 8(3): 230-42.
Luo Y, Vali S, Sun S, Chen X, Liang X, Drozhzhina T, Popugaeva E, Bezprozvanny I. Aβ42-binding peptoids as amyloid aggregation inhibitors and detection ligands. ACS Chemical Neuroscience 2013 4(6), pp 952–962
Nan-Jie Xu, Suya Sun, Jay R. Gibson, and Mark Henkemeyer, A dual-shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses Nature Neuroscience 2011 14(11): 1421–1429.
Hua Zhang, Suya Sun （共同第一作者）, An Herreman, Bart De Strooper, and Ilya Bezprozvanny Role of presenilins in neuronal calcium homeostasis The Journal of Neuroscience 2010 30(25): 8566–8580