导师姓名： 王刚 专业代码： 100204
性别： 男 专业名称： 神经病学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市黄浦区瑞金二路197号瑞金医院神经内科
邮编： 200025 邮箱地址： wgneuron@hotmail.com

研究方向 (点击浏览详细信息)
神经变性疾病(阿尔茨海默病和帕金森病)

社会任职
中国人脑组织库协作联盟学术委员会委员
中国神经科学学会神经退行性疾病分会常委兼秘书长
中国医师协会老年医学分会青年委员
《诊断学理论与实践杂志》编委
中国微循环学会神经变性病专委会脑积水学组委员
中华医学会神经病学分会痴呆及认知障碍学组委员
中国医师协会神经内科分会第一届青年委员会副主任委员
中国医师协会神经内科分会委员
《内科理论与实践杂志》 特约编委
中国医师协会神经内科分会脑与脊髓损伤专委会委员
中国微循环学会神经变性病专委会分子影像学组常委
Associate Editor of the Journal of Alzheimer's Disease
中国老年医学学会认知障碍分会常委兼青年委员会副主任委员
中华医学会老年医学分会青年委员
Member of The Movement Disorder Society (MDS)
Editoral member of the Journal Gene & Disease

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
ZHYY-ZXYJHZX-202006 针药结合治疗轻度阿尔茨海默病的临床疗效及其作用机制研究 上海市综合医院中西医结合专项 2020-06~2022-06 10万元 课题负责人
** microRNA-425调控坏死性凋亡介导多巴胺能神经元变性的机制研究 国家自然科学基金委员会 2020-01~2023-12 55万元 课题负责人
19ZR** ROCK1介导的神经元ELS酸化功能障碍在阿尔茨海默病发病机制中的研究 上海市科学技术委员会 2019-07~2021-07 20万元 课题负责人
2018 ****医学人才 上海市“医苑新星”青年医学人才培养资助计划 2019-01~2022-01 20万元 课题负责人
TM201704 采用ASR语言评估软件对神经变性疾病进行辅助诊断和预后评估的转化研究 上海市转化医学协同创新中心合作研究项目 2017-12~2019-11 19万元 课题负责人
2017 外周血sLAG3作为帕金森病潜在生物标志物的临床转化研究 上海交通大学医学院高峰高原计划—“研究型医师” 2017-07~2020-06 100万元 课题负责人
16SG15 重复经颅磁刺激对轻度认知功能障碍及早期AD患者的治疗作用及其机制的临床研究 上海市曙光计划 2017-01~2019-12 15万元 课题负责人
** 采用尿液代谢组学筛选轻度认知功能障碍患者早期生物标志物的转化研究 上海交通大学医学院转化医学协同创新中心合作研究项目 2015-12~2017-12 20万元 课题负责人
15PJ** miR-29调节IGF-1信号通路参与阿尔茨海默病发病及成为潜在治疗靶点和生物学标志物的实验研究 上海市科委浦江人才计划(A类) 2015-07~2017-06 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chen SW, Wang YK, Dou RH, Xie XY, Hu YB, Ding N, Zhang GH, Jing HF, Zhao WD, Xue Y, Li Y, Wang G （通讯作者） Characteristics of the 24-h ambulatory blood pressure monitoring in patients with Parkinson's disease – the SFC BP multicentre study in China Journal of Hypertension 2020 Jul 6. doi: 10.1097/HJH.2536.
Liu XY, Shi Q, Wang G （通讯作者） Long survival sporadic Creutzfeldt-Jakob disease Neurology 2020 10.1212/WNL.9793. doi: 10.1212/WNL.9793.
Qiao Y, Xie XY, Lin GZ, Zou Y, Chen SD, Ren RJ, Wang G （通讯作者） Computer-Assisted Speech Analysis in Mild Cognitive Impairment and Alzheimer's Disease: A Pilot Study from Shanghai, China J Alzheimers Dis 2020 75(1):211-221. doi: 10.3233/JAD-191056.
Zhang YQ, Wang CF, Xu G, Zhao QH, Xie XY, Cui HL, Wang Y, Ren RJ, Guo QH, Wang G. （通讯作者） Mortality of Alzheimer's Disease Patients: A 10-Year Follow-up Pilot Study in Shanghai. Can J Neurol Sci. 2020 47(2):226-230. doi: 10.1017/cjn.2019.333
Cui H, Ren R, Lin G, Zou Y, Jiang L, Wei Z, Li C, Wang G （通讯作者） Repetitive Transcranial Magnetic Stimulation Induced Hypoconnectivity Within the Default Mode Network Yields Cognitive Improvements in Amnestic Mild Cognitive Impairment: A Randomized Controlled Study J Alzheimers Dis 2019 69(4):1137-1151
Gao Y, Ren RJ, Zhong ZL, Dammer E, Zhao QH, Shan S, Zhou Z, Li X, Zhang YQ, Cui HL, Hu YB, Chen SD, Chen JJ, Guo QH, Wang G （通讯作者） Mutation profile of APP, PSEN1, and PSEN2 in Chinese familial Alzheimer's disease. Neurobiol Aging 2019 77:154-157
郭起浩,王刚 （通讯作者）,武力勇。 痴呆及相关认知障碍的神经心理诊断流程 重庆医科大学学报 2019 44(4)：393-396
Yue-qi Zhang, Ya-bin Tang, Eric Dammer, Jian-ren Liu, Yu-wu Zhao, Liang Zhu, Ru-jing Ren, Hong-zhuan Chen, Gang Wang （通讯作者）, Qi Cheng. Dysregulated Urinary Arginine Metabolism in Older Adults With Amnestic Mild Cognitive Impairment Front. Aging Neurosci 2019 11:90. doi: 10.3389/fnagi.2019.00090. eCollection 2019
Hu YB, Zhang YF, Wang H, Ren RJ, Cui HL, Huang WY, Cheng Q, Chen HZ, Wang G （通讯作者） miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease. Cell Death Dis 2019 10(8):589.
Cui SS, Du JJ, Liu SH, Meng J, Lin YQ, Li G, He YX, Zhang PC, Chen S, Wang G （通讯作者） Serum soluble lymphocyte activation gene-3 as a diagnostic biomarker in Parkinson's disease: A pilot multicenter study. Mov Disord 2019 34(1):138-141.
Hu YB, Ren RJ, Zhang YF, Huang Y, Cui HL, Ma C, Qiu WY, Wang H, Cui PJ, Chen HZ, Wang G （通讯作者） Rho-associated coiled-coil kinase 1 activation mediates amyloid precursor protein site-specific Ser655 phosphorylation and triggers amyloid pathology. Aging Cell 2019 Jul 9:e13001.
Yueqi Zhang, Gang Wang （通讯作者） Response to: Sudden death in Parkinson's disease: Unjustifiably forgotten Parkinsonism Relat Disord 2018 58:87. doi: 10.1016/j.parkreldis.2018.08.013
Ying Gao, Xia Li, Xiao-Hong Liu, Qian-Hua Zhao, Xiang-Qian Che, Qi-Hao Guo, Ru-Jing Ren, Gang Wang （通讯作者） Determining association of rho kinase 1 gene polymorphisms with risk of Alzheimer’s disease: a multicenter pilot study Annals of Translational Medicine 2018 6(22):434
Gang Wang, Hai-lun Cui, Yue Huang Reader response: Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium Neurology 2018 90:300.
Yueqi Zhang, Chunfang Wang, Ying Wang, Qin Xiao, Jun Liu, Jianfang Ma, Haiyan Zhou, Jing Pan, Yuyan Tan, Shengdi Chen, Gang Xu, Gang Wang （通讯作者） Mortality from Parkinson's disease in China: Findings from a ten-year follow up study in Shanghai Parkinsonism Relat Disord 2018 May 22. pii: S1353-8020(18)30242-6. doi: 10.1016/j.parkreldis.2018.05.012. [Epub ahead of print]
崔海伦,张一帆,管晓军,黄沛钰,刘志蓉,袁园,刘晓云,朱红灿,曹学兵, 陈玲,陈先文,陈燕,商慧芳,杨任民,陈生弟,张敏鸣,王刚 （通讯作者） 帕金森病及相关运动障碍的神经影像学诊断专家共识 诊断学理论与实践杂志 2018 17(4):403-408
Wang G, Cui HL. Reader response: Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology 2018 91(8):371-372
Che XQ, Song N, Gao Y, Ren RJ, Wang G Precision medicine of frontotemporal dementia: from genotype to phenotype. Front Biosci (Landmark Ed). 2018 Jan 1;23:1144-1165.
Che XQ, Zhao QH, Huang Y, Li X, Ren RJ, Chen SD, Guo QH, Wang G （通讯作者） Mutation Screening of the CHCHD2 Gene for Alzheimer's Disease and Frontotemporal Dementia in Chinese Mainland Population J Alzheimers Dis 2018 61(4):1283-1288
Gang Wang （共同第一作者）, Hai-Lun Cui, Jun Liu, Qin Xiao, Ying Wang, Jian-Fang Ma, Hai-Yan Zhou, Jing Pan, Yu-Yan Tan, Sheng-Di Chen Current approaches for the management of Parkinson’s disease in Chinese hospitals: a cross-sectional survey BMC Neurology 2018 18:122
Qiu W, Zhang H, Bao A, Zhu K, Huang Y, Yan X, Zhang J, Zhong C, Shen Y, Zhou J, Zheng X, Zhang L, Shu Y, Tang B, Zhang Z, Wang G, Zhou R, Sun B, Gong C, Duan S, Ma C. Standardized Operational Protocol for Human Brain Banking in China. Neurosci Bull 2018 Nov 8. doi: 10.1007/s12264-018-0306-7
Zou Y, Song N, Hu YB, Gao Y, Zhang YQ, Zhao QH, Guo QH, Li X, Li GJ, Xiao SF, Chen SD, Ren RJ, Wang G. （通讯作者） Caregivers' attitude toward disclosure of Alzheimer's disease diagnosis in Urban China. Int Psychogeriatr. 2017 29(11):1849-1855
Che XQ, Zhao QH, Huang Y, Li X, Ren RJ, Chen SD, Wang G （通讯作者）, Guo QH. Genetic Features of MAPT, GRN, C9orf72 and CHCHD10 Gene Mutations in Chinese Patients with Frontotemporal Dementia Curr Alzheimer Res 2017 14(10):1102-1108
王刚,吕发金. 痴呆及相关认知障碍的神经影像学诊断流程建议 重庆医科大学学报 2017 42(6):680-682
Shi-Shuang Cui, Ru-Jing Ren, Ying Wang, Gang Wang （通讯作者）,Sheng-Di Chen Tics as an initial manifestation of juvenile Huntington’s disease: case report and literature review BMC Neurology 2017 17(1):152.
Yang SS, Zhang R, Wang G （通讯作者）, Zhang YF The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease. Transl Neurodegener 2017 6:19.
Zhang B, Wang LL, Ren RJ, Dammer EB, Zhang YF, Huang Y, Chen S, Wang G （通讯作者） MicroRNA-146a represses LRP2 translation and leads to cell apoptosis in Alzheimer's disease. FEBS Lett 2016 590(14):2190-200
Hu YB, Zou Y, Huang Y, Zhang YF, Lourenco GF, Chen SD, Halliday GM, Wang G （通讯作者）, Ren RJ. ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance. Front Cell Neurosci 2016 10:253
王刚 疾病探案之美 医学与哲学 2016 37（11）：48-49
Ren RJ, Zhang YF, Dammer EB, Zhou Y, Wang LL, Liu XH, Feng BL, Jiang GX, Chen SD, Wang G （通讯作者）, Cheng Q Peripheral Blood MicroRNA Expression Profiles in Alzheimer's Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism Mol Neurobiol. 2016 53(8):5772-81
Yong-Bo Hu, Chun-Bo Li, Ning Song, Yang Zou, Sheng-Di Chen, Ru-Jing Ren,Gang Wang （通讯作者） Diagnostic value of microRNA for Alzheimer's disease: a systematic review and meta-analysis Frontiers in Aging Neuroscience 2016 8:13
Wang G （共同第一作者）, Huang Y, Wang LL, Zhang YF, Xu J, Zhou Y, Lourenco GF, Zhang B, Wang Y, Ren RJ, Halliday GM, Chen SD. MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease. Sci Rep 2016 May 25;6:26697. doi: 10.1038/srep26697.
王刚（执笔作者之一:中国老年医学学会认知障碍分会认知障碍患者照料及管理专家共识撰写组） 中国认知障碍患者照料管理专家共识 中华老年医学杂志 2016 35（10）：1051-1060
上海交通大学医学院附属瑞金医院;上海交通大学 认知功能障碍筛查用ASR语音识别软件V1.3 国家版权局计算机软件著作权登记证书 2016 2016SR164680
Gang Wang, Yue Huang, Wei Chen, Shuai Chen, Ying Wang, Qin Xiao, Jun Liu, Victor S.C. Fung, Glenda Halliday, Shengdi Chen Variants in the SNCA gene associate with motor progression while variants in the MAPT gene associate with the severity of Parkinson's disease Parkinsonism Relat Disord 2015 December 30 2015
Huang Y, Wang G （共同第一作者）, Rowe D, Wang Y, Kwok JB, Xiao Q, Mastaglia F, Liu J, Chen SD, Halliday G SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson's Disease in Chinese and Australians. Biomed Res Int. 2015 2015:135674
Hu YB, Dammer EB, Ren RJ, Wang G. （通讯作者） The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration. Transl Neurodegener. 2015 Sep 30;4:18.
Xu J, Wang LL, Dammer EB, Li CB, Xu G, Chen SD, Wang G. （通讯作者） Melatonin for Sleep Disorders and Cognition in Dementia: A Meta-Analysis of Randomized Controlled Trials. Am J Alzheimers Dis Other Demen 2015 Jan 22
Xu J, Xia LL, Song N, Chen SD, Wang G. （通讯作者） Testosterone, Estradiol, and Sex Hormone-Binding Globulin in Alzheimer's Disease: A Meta-Analysis Curr Alzheimer Res 2015 2015 Dec 18. [Epub ahead of print]
王刚（执笔作者之一:中华医学会老年医学分会老年神经病学组记忆门诊标准操作规程专家组）。 记忆门诊标准操作规程指南 中华老年医学杂志 2015 819-828
Wang G, Li XJ, Hu YS, Cheng Q, Wang CF, Xiao Q, Liu J, Ma JF, Zhou HY, Pan J, Tan YY, Wang Y,Chen SD Mortality from Parkinson’s disease in China: Findings from a five-year follow up study in Shanghai Canadian Journal of Neurological Sciences 2015 42(4):242-247
Wang G （共同第一作者）, Zhou Y, Huang FJ, Tang HD, Xu XH, Liu JJ, Wang Y, Deng YL, Ren RJ, Xu W, Ma JF, Zhang YN, Zhao AH, Chen SD, Jia W Plasma Metabolite Profiles of Alzheimer's Disease and Mild Cognitive Impairment J Proteome Res 2014 13(5):2649-58
Wang G （共同第一作者）, Tang HD, Zhuang JP, Xu XH, Liu LH, Li B, Wang LL, Xu ZM, Cheng Q, ChenSD Risk Factors for Cognitive Decline in Elderly People: Findings from theTwo-year Follow-Up Study in Shanghai Urban Community J Alzheimers Dis 2014 39(4):891-897
Liu LH, Xu J, Deng YL, Tang HD, Wang Y, Ren RJ, Xu W, Ma JF, Wang G （通讯作者）, Chen SD A Complex Association of ABCA7 Genotypes With Sporadic Alzheimer Disease inChinese Han Population Alzheimer Dis Assoc Disord 2014 28(2):141-144
Fang R, Wang G （共同第一作者）, Huang Y, Zhuang JP, Tang HD, Wang Y, Deng YL, Xu W, Chen SD,Ren RJ Validation of the Chinese Version of Addenbrooke's CognitiveExamination-Revised for Screening Mild Alzheimer's Disease Dement Geriatr Cogn Disord 2014 37(3-4):223-231
Ren RJ, Huang Y, Xu G, Li CB, Cheng Q, Chen SD, Wang G （通讯作者） History, present, and progress of frontotemporal dementia in china: a systematic review. Int J Alzheimers Dis 2012 2012:587215
Chen W, Chen S, Kang WY, Li B, Xu ZM, Xiao Q, Liu J, Wang Y, Wang G （通讯作者）, Chen SD Application of odor identification test in Parkinson's disease in China: a matched case-control study J Neurol Sci 2012 316(1-2):47-50
Wang G, Pan J, Chen SD Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson's disease. Prog Neurobiol 2012 98(2):207-21
Deng YL, Liu LH, Wang Y, Tang HD, Ren RJ, Xu W, Ma JF, Wang LL, Zhuang JP, Wang G （通讯作者）, Chen SD The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease. Hum Genet 2012 131(7):1245-9
Gui YX, Fan XN, Wang HM, Wang G （通讯作者）, Chen SD Glyphosate induced cell death through apoptotic and autophagic mechanisms. Neurotoxicol Teratol 2012 34(3):344-9
Chen W, Chen S, Xiao Q, Wang G （通讯作者）, Chen SD Current clinical practice for Parkinson's disease among Chinese physicians, general neurologists and movement disorders specialists: a national survey BMC Neurol 2012 12(1):155-164
Chen W, Xu ZM, Wang G （通讯作者）, Chen SD Non-motor symptoms of Parkinson's disease in China: a review of the literature Parkinsonism Relat Disord 2012 18(5):446-52
Gui YX, Wan Y, Xiao Q, Wang Y, Wang G （通讯作者）, Chen SD Verification of expressions of Kir2 as potential peripheral biomarkers in lymphocytes from patients with Parkinson's disease Neurosci Lett 2011 505(2):104-8
Wang G, Pan XL, Cui PJ, Wang Y, Ma JF, Ren RJ, Deng YL, Xu W, Tang HD, Chen SD Association study of the GAB2 gene with the risk of Alzheimer disease in the chinese population Alzheimer Dis Assoc Disord 2011 25(3):283-5
Wang G, Fan XN, Tan YY, Cheng Q, Chen SD Parkinsonism after chronic occupational exposure to glyphosate Parkinsonism Relat Disord 2011 17(6):486-7
Wang LL, Pan XL, Wang Y, Tang HD, Deng YL, Ren RJ, Xu W, Ma JF, Wang G （通讯作者）, Chen SD A single nucleotide polymorphism in LRP2 is associated with susceptibility to Alzheimer's disease in the Chinese population Clin Chim Acta 2011 412(3-4):268-70
Ren RJ, Wang LL, Fang R, Liu LH, Wang Y, Tang HD, Deng YL, Xu W, Wang G （通讯作者）, Chen SD The MTHFD1L gene rs** marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population J Neurol Sci 2011 308(1-2):32-4
Wang G, Wan Y, Cheng Q, Xiao Q, Wang Y, Zhang J, Ma JF, Wang XJ, Zhou HY, Chen SD Malnutrition and associated factors in Chinese patients with Parkinson's disease: Results from a pilot investigation. Parkinsonism Relat Disord 2010 16(2):119-23
Wang G, Wan Y, Wang Y, Xiao Q, Liu J, Ma JF, Wang XJ, Zhou HY, Tan YY, Cheng Q, Chen SD Visual hallucinations and associated factors in Chinese patients with Parkinson's disease: roles of RBD and visual pathway deficit. Parkinsonism Relat Disord 2010 16(10):695-6