导师姓名： 陈生弟 专业代码： 100204
性别： 男 专业名称： 神经病学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 200025 邮箱地址： chensd@rjh.com.cn

研究方向 (点击浏览详细信息)
帕金森病/阿尔茨海默病的基础与临床研究

社会任职
担任国际杂志《Translational Neurodegeneration》主编、《Journal of Alzheimer’s disease》副主编、《Journal of Neuroimmunology & Pharmacology》、《Alzheimer & Dementia》、《Current Alzheimer Research》、《Neurodegenerative Disease Management》、《Neuroscience Bulletin》编委。担任国内杂志《中华神经科杂志》、《中国神经精神疾病杂志》、《中国神经免疫与神经病学杂志》等副主编。
国际神经病学联盟帕金森病及相关疾病研究委员会委员、中华医学会神经病学分会副主委兼帕金森病及运动障碍学组组长、、中国神经科学学会副理事长、中华医学会老年医学分会常委、中国医师协会神经内科医师分会及老年医学分会副会长、中华中医药学络病学分会副主委、第十届国家药典委员会医学专业副主委、中国老年学学会老年医学委员会认知障碍专家委员会副主委、上海医师协会老年医师分会会长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
无 认知训练早期干预轻度认知障碍的多中心、随机、前瞻性 上海交通大学医学院 2016-07~2017-07 100万元 课题负责人
无 帕金森病及运动并发症临床前预警，治疗及炎症发病机制研究 交大医学院脑疾病临床研究中心 2015-05~2017-05 80万元 课题负责人
** 散发性帕金森病中DJ-1表达异常的机制及在早期诊断中的应用 国家自然科学基金重点项目 2015-01~2018-12 320万元 课题负责人
** 环境因素对海马神经环路更新的影响在阿尔茨海默病发生发展中的作用及其机制研究 国家自然科学基金重大培育 2014-01~2016-12 100万元 课题负责人
** Mortalin泛素化修饰异常在氧化应激导致帕金森病发病中的作用及其机制 国家自然科学基金 2014-01~2017-12 70万元 课题负责人
** 突触共核蛋白导致胶质细胞激活的机制研究制研究 国家自然科学基金 2012-01~2015-12 120万元 课题负责人
2011CB504104 帕金森病发病机制和干预策略的基础研究 科技部973计划 2011-01~2015-12 200万元 子课题负责人
YG2010ZD102 磁-介孔/siRNA-BTA纳米复合物在老年痴呆症早期诊断和治疗中的应用研究 上海交通大学医工合作重大项目 2010-10~2012-10 40万元 课题负责人
帕金森病早期诊断、优化治疗及有效预防的临床研究 上海市科委 2010-07~2013-10 20万元 课题负责人
** DJ-1基因调控SOD1表达发挥抗氧化作用的分子机制研究 国家自然科学基金 2010-01~2012-12 35万元 课题负责人
2010CB945200 基于诱导多能干细胞技术的若干重大疾病模型与机理研究 科技部973计划 2010-01~2014-12 150万元 课题参与人
C090301 DJ-1基因调控SOD1表达发挥抗氧化作用的分子机制研究 国家自然基金，面上项目 2010-01~2012-12 35万元

学术论文 作者论文标题期刊名出版年卷期页码
Li, B. Y,Tang （通讯作者）, H. D,Chen, S. D. Retrieval Deficiency in Brain Activity of Working Memory in Amnesic Mild Cognitive Impairment Patients: A Brain Event-Related Potentials Study Front Aging Neurosci 2016 8
Wang G, Huang Y, Wang LL, Zhang YF, Xu J, Zhou Y, Lourenco GF, Zhang B, Wang Y, Ren RJ, Halliday GM, Chen SD （通讯作者）, Wang G, Huang Y, Wang LL, Zhang YF, Xu J, Zhou Y, Lourenco GF, Zhang B, Wang Y, Ren RJ, Halliday GM, Chen SD, Sci Rep 2016 6
Z Xu, H Jiang, P Zhong, Z Yan, S Chen,J Feng. （通讯作者） Direct conversion of human fibroblasts to induced serotonergic neurons Mol Psychiatry 2016 21(1):62-70.
Zhang, L.Y., Liu, W.Y., Kang, W.Y., Yang, Q. （通讯作者）, Wang, X.Y., Ding, J.Q., Chen, S.D., Liu, J. Association of rapid eye movement sleep behavior disorder with sleep-disordered breathing in Parkinson's disease Sleep medicine 2016 20:110-115
Li, D. H,He, Y. C （通讯作者）,Liu, J,Chen, S. D. Diagnostic Accuracy of Transcranial Sonography of the Substantia Nigra in Parkinson's disease: A Systematic Review and Meta-analysis Sci Rep 2016 6:20863
Sun Q, Wang T, Jiang TF, Huang P, Li DH, Wang Y, Xiao Q, Liu J, Chen SD （通讯作者） Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson's Disease Patients, Aging Dis 2016 7:230-236
Wu Y, Wang X, Wang C, Sun Q, Song N, Zhou Y, Jiang Q, Qiao Y, Xu J, Liang L, Tang H, Ma J, Gao X, Chen SD （通讯作者） Prevalence and clinical features of non-motor symptoms of essential tremor in Shanghai rural area Parkinsonism Relat Disord 2016 22:15-20
Huang P, Fang R, Li BY, Chen SD. （通讯作者） Exercise-Related Changes of Networks in Aging and Mild Cognitive Impairment Brain. Front Aging Neurosci 2016 8(47):1-11
Zhou, H.Y., Sun, Q., Tan, Y.Y., Hu, Y.Y., Zhan, W.W. （通讯作者）, Li, D.H., Wang, Y., Xiao, Q., Liu, J.,Chen, S.D. Substantia nigra echogenicity correlated with clinical features of Parkinson's disease Parkinsonism & related disorders 2016 24,28-33
Zhang B, Wang LL, Ren RJ, Dammer EB, Zhang YF, Huang Y, Chen SD, Wang G （通讯作者） MicroRNA-146a represses LRP2 translation and leads to cell apoptosis in Alzheimer's disease FEBS Lett 2016 590:2190-2200
Zhou Y, Fang R, Liu LH, Chen SD （通讯作者）, Tang HD Clinical Characteristics for the Relationship between Type-2 Diabetes Mellitus and Cognitive Impairment: A Cross-Sectional Study Aging Dis 2015 6(4):236-44
Jiang QW, Wang C, Zhou Y, Hou MM, Wang X, Tang HD, Wu YW, Ma JF, Chen SD （通讯作者） Plasma epidermal growth factor decreased in the early stage of Parkinson's disease Aging Dis 2015 6(3):168-73
Tang HD, Zhou Y, Gao X, Liang L, Hou MM, Qiao Y, Ma JF, Chen SD （通讯作者） Prevalence and Risk Factor of Cognitive Impairment were Different between Urban and Rural Population: A Community-Based Study J Alzheimers Dis 2015 Oct 27
Liu XL, Wang T, Huang XJ, Zhou HY, Luan XH, Shen JY, Chen SD （通讯作者）, Cao L Novel ATM mutations with ataxia-telangiectasia Neurosci Lett 2015 611:112-5
Jiang T, Hoekstra J, Heng X, Kang W, Ding J, Liu J, Chen S （通讯作者）, Zhang J P2X7 receptor is critical in α-synuclein--mediated microglial NADPH oxidase activation Neurobiol Aging 2015 36(7):2304-18
Pan J, Li H, Zhang B, Xiong R, Zhang Y, Kang WY, Chen W, Zhao ZB, Chen SD （通讯作者） Small peptide inhibitor of JNK3 protects dopaminergic neurons from MPTP induced injury via inhibiting the ASK1-JNK3 signaling pathway PLoS One 2015 10(4)
Chen W, Kang WY, Chen S, Wang Y, Xiao Q, Wang G, Liu J, Chen SD （通讯作者） Hyposmia correlates with SNCA variant and non-motor symptoms in Chinese patients with Parkinson's disease Parkinsonism Relat Disord 2015 21(6):610-4
Ren RJ, Zhang YF, Dammer EB, Zhou Y, Wang LL, Liu XH, Feng BL, Jiang GX, Chen SD （通讯作者）, Wang G, Cheng Q Peripheral Blood MicroRNA Expression Profiles in Alzheimer's Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism Mol Neurobiol 2015 Oct 26
Huang P, Yang XD, Chen SD （通讯作者）, Xiao Q The association between Parkinson's disease and melanoma: a systematic review and meta-analysis Transl Neurodegener 2015 4:21
Fang R, Yan XX, Wu ZY, Sun Y, Yin QH, Wang Y, Tang HD, Sun JF, Miao F, Chen SD （通讯作者） Disrupted Structural Brain Network in AD and aMCI: A Finding of Long Fiber Degeneration Curr Alzheimer Res 2015 12(6):572-84
Gusdon AM, Fang F, Chen J, Mathews CE, Li W, Chu CT, Ding JQ, Chen SD （通讯作者） Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease Neurosci Lett. 2015 587:98-101
Huang Y, Wang G, Rowe D, Wang Y, Kwok JB, Xiao Q, Mastaglia F, Liu J, Chen SD （通讯作者）, Halliday G SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson's Disease in Chinese and Australians Biomed Res Int 2015 2015:135674
Li DH, Zhang LY, Hu YY, Jiang XF, Zhou HY, Yang Q, Kang WY, Liu J, Chen SD （通讯作者） Transcranial sonography of the substantia nigra and its correlation with DAT-SPECT in the diagnosis of Parkinson's disease Parkinsonism Relat Disord 2015 21(8):923-8
Jiang QW, Wang C, Zhou Y, Hou MM, Wang X, Tang HD, Wu YW, Ma JF, Chen SD （通讯作者） Plasma epidermal growth factor decreased in the early stage of Parkinson's disease Aging & Dis 2015 6(3):168-73
Huang XJ, Wang T, Wang JL, Liu XL, Che XQ, Li J, Mao X, Zhang M, Bi GH, Wu L, Zhang Y, Wang JY, Shen JY, Tang BS, Cao L, Chen SD （通讯作者） Paroxysmal kinesigenic dyskinesia: Clinical and genetic analyses of 110 patients Neurology 2015 85(18):1546-53
Wang G, Li XJ, Hu YS, Cheng Q, Wang CF, Xiao Q, Liu J, Ma JF, Zhou HY, Pan J, Tan YY, Wang Y, Chen SD （通讯作者） Mortality from Parkinson's disease in China: Findings from a five-year follow up study in Shanghai Can J Neurol Sci 2015 42(4):242-7
Pan J, Li H, Ma JF, Tan YY, Xiao Q, Ding JQ, Chen SD （通讯作者） Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease through suppressing mitochondria dysfunction Transl Neurodegener 2015 10(4)
Deng Y, Xiong Z, Chen P, Wei J, Chen S （通讯作者）, Yan Z β-amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3 Neurobiol Aging 2014 35(3):449-59
Xiong R, Wang Z, Zhao Z, Li H, Chen W, Zhang B, Wang L, Wu L, Li W, Ding J, Chen S （通讯作者） MicroRNA-494 reduces DJ-1 expression and exacerbates neurodegeneration Neurobiol Aging 2014 35(3):705-14
Chen W, Xiao Q, Shao M, Feng T, Liu WG, Luo XG, Chen XC, Xie AM, Liu CF, Liu ZG, Liu YM, Wang J, Chen SD （通讯作者） Prevalence of wearing-off and dyskinesia among the patients with Parkinson's disease on levodopa therapy: a multi-center registry survey in mainland China Transl Neurodegener 2014 3(1):26
Wu L, Tang HD, Huang XJ, Zheng L, Liu XL, Wang T, Wang JY, Cao L, Chen SD （通讯作者） PRRT2 truncated mutations lead to nonsense-mediated mRNA decay in Paroxysmal Kinesigenic Dyskinesia Parkinsonism Relat Disord 2014 20(12):1399-404
Lu L, Tang L, Wei W, Hong Y, Chen H, Ying W, Chen S （通讯作者） Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson's disease Exp Ther Med 2014 8(3):943-950
Cheng Q, Sun HX, Ye FL, Wang G, Ling HW, Chen SD （通讯作者）, Jiang GX Dementia among elderly in Shanghai suburb: a rural community survey J Alzheimer’s Dis 2014 39(4):883-9.
Kang WY, Yang Q, Jiang XF, Chen W, Zhang LY, Wang XY, Zhang LN, Quinn TJ, Liu J, Chen SD （通讯作者） Salivary DJ-1 could be an indicator of Parkinson's disease progression Front Aging Neurosci 2014 6:102
Wang XY, Kang WY, Yang Q, Zhang LY, Chen SD （通讯作者）, Liu J. Using gastrocnemius sEMG and plasma α-synuclein for the prediction of freezing of gait in Parkinson's disease patients PLoS One 2014 9(2):e89353
Wu H, Dong F, Wang Y, Xiao Q, Yang Q, Zhao J, Quinn TJ, Chen SD （通讯作者）, Liu J Catechol-O-methyltransferase Val158Met polymorphism: modulation of wearing-off susceptibility in a Chinese cohort of Parkinson's disease Parkinsonism Relat Disord 2014 20(10):1094-6
Tan YY, Wu L, Zhao ZB, Wang Y, Xiao Q, Liu J, Wang G, Ma JF, Chen SD （通讯作者） Methylation of α-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients Parkinsonism Relat Disord 2014 20(3):308-13
Chen JM, Cui GH, Jiang GX, Xu RF, Tang HD, Wang G, Chen SD （通讯作者）, Cheng Q Cognitive impairment among elderly individuals in Shanghai suburb, China: association of C-reactive protein and its interactions with other relevant factors. Am J Alzheimers Dis Other Demen 2014 29(8):712-7
Zhao ZB, Wu L, Xiong R, Wang LL, Zhang B, Wang C, Li H, Liang L, Chen SD （通讯作者） MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer's disease Neuroscience 2014 275:232-7
Wang G, Zhou Y, Huang FJ, Tang HD, Xu XH, Liu JJ, Wang Y, Deng YL, Ren RJ, Xu W, Ma JF, Zhang YN, Zhao AH, Chen SD （通讯作者）,Jia W Plasma metabolite profiles of Alzheimer's disease and mild cognitive impairment J Proteome Res 2014 13(5):2649-58
Wang G, Tang HD, Zhuang JP, Xu XH, Liu LH, Li B, Wang LL, Xu ZM, Cheng Q, Chen SD （通讯作者） Risk factors for cognitive decline in elderly people: findings from the two-year follow-up study in a Shanghai urban community J Alzheimer’s Dis 2014 39(4):891-7
Liu LH, Xu J, Deng YL, Tang HD, Wang Y, Ren RJ, Xu W, Ma JF, Wang G, Chen SD （通讯作者） A complex association of ABCA7 genotypes with sporadic Alzheimer disease in Chinese Han population Alzheimer Dis Assoc Disord. 2014 28(2):141-4
Li H, Zhang Y, Cao L, Xiong R, Zhang B, Wu L, Zhao Z, Chen SD （通讯作者） Curcumin could reduce the monomer of TTR with Tyr114Cys mutation via autophagy in cell model of familial amyloid polyneuropathy Drug Des Devel Ther 2014 8:2121-8
Sheng CY, Xiong R, Li H, Zhang GN, Zhang S, Heng X, Chen SD （通讯作者） J-1 deficiency down-regulates tuj1 and impairs neurites outgrowth in striatum Neurobiol Aging 2013 34：489-498
Liu J, Xiao Q, Wang Y, Xu ZM, Wang Y, Yang Q, Wang G, Tan YY, Ma JF, Zhang J, Huang W, Chen SD （通讯作者） Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China Mov Disord 2013 28(13):1892-5
Ren RJ, Huang Y, Xu G, Li CB, Cheng Q, Chen SD （通讯作者）, Wang G History, present, and progress of frontotemporal dementia in china: a systematic review Int J Alzheimers Dis 2012
Fu Y, Ni PH, Ma JF, Ying YY, Zhao J, Liu JR, Guo ZL, Shengdi Chen （通讯作者） Polymorphisms of human vascular endothelial growth factor gene are associated with acute cerebral infarction in the Chinese population Eur Neurol 2011 66(1):47-52
Wang HM,Ma JF, Tan YY, Wang ZQ, Sheng CY, Ding JQ, Chen SD （通讯作者） Aβ1–42 induces ROS-mediated autophagic cell death in U87 and SH-SY5Y cells J Alzheimer’s Dis 2010 21(2):597-610
Jing Pan, Jing Qian, Yu Zhang, Jianfang Ma, Gang Wang, Qin Xiao, Shengdi Chen （通讯作者）, Jianqing Ding Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic injury via inhibiting the JNK-signaling pathway Laboratory Investigation 2010 90:156–167
Hong-Mei Wang, Yan-Xin Zhao, Shi Zhang, Gui-Dong Liu, Wen-Yan Kang, Hui-Dong Tang, Jian-Qing Ding and Shengdi Chen PPARγ agonist curcumin reduces the β-amyloid-stimulated inflammatory responses in primary astrocytes J Alzheimer’s Dis 2010 20(4):1189-99
Qun Xu, Yan Zhou, Wen-wei Cao, Yan Lin （通讯作者）, Yuan-mei Pan, Yan-sheng Li, Shengdi Chen Diffusion Tensor Imaging Changes Correlate with Cognition Better Than Conventional MRI Findings in Patients with Subcortical Ischemic Vascular Disease Dementia and Geriatric Cognitive Disorders 2010 30(4):317-26
Huang Y, Zheng L, Halliday G, Dobson-Stone C, Wang Y, Tang HD, Cao L, Deng YL, Wang G, Zhang YM, Wang JH, Hallupp M, Kwok J, Chen SD （通讯作者） Genetic polymorphisms in sigma-1 receptor and apolipoprotein E interact to influence the severity of Alzheimer's disease Curr Alzheimer Res 8(7):765-70
Wang JL, Cao L, Li XH, Hu ZM, Li JD, Zhang JG, Liang Y, San-A, Li N, Chen SQ, Guo JF, Jiang H, Shen L, Zheng L, Mao X, Yan WQ, Zhou Y, Shi YT, Ai SX, Dai MZ, Zhang P, Xia K, Chen SD （通讯作者）,Tang BS Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias Brain 134(Pt 12):3493-3501
Zhiquan Wang, Siyan Chen, Ying Wang, Li Cao, Yu Zhang, Ya-Xing Gui, Shengdi Chen （通讯作者）,Jian-Qing Ding Park7/DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the ERK1/2-Elk-1 pathway in neuroprotection Ann Neurol 70(4):591-9
Fei QZ, Cao L, Xiao Q, Zhang T, Zheng L, Wang XJ, Wang G, Zhou HY, Wang Y, Shengdi Chen （通讯作者） Lack of association between ATP13A2 Ala746Thr variant and Parkinson's disease in Han population of mainland China Neurosci Lett 475(2):61-3
Wang G, Pan XL, Cui PJ, Wang Y, Ma JF, Ren RJ, Deng YL, Xu W, Tang HD, Shengdi Chen （通讯作者） Association Study of the GAB2 Gene With the Risk of Alzheimer Disease in the Chinese Population Alzheimer Dis Assoc Disord 25(3):283-5
Cui PJ, Zheng L, Cao L, Wang Y, Deng YL, Wang G, Xu W, Tang HD, Ma JF, Zhang T, Ding JQ, Cheng Q, Shengdi Chen （通讯作者） CALHM1 P86L polymorphism is a risk factor for Alzheimer's disease in the Chinese population J Alzheimer’s Dis 19(1):31-5
Gui YX, Fan XN, Wang HM, Wang G, Chen SD （通讯作者） Glyphosate induced cell death through apoptotic and autophagic mechanisms Neurotoxicol Teratol
Cui GH, Yao YH, Xu RF, Tang HD, Jiang GX, Wang Y, Wang Shengdi Chen# （通讯作者）, Cheng Q Cognitive impairment using education-based cutoff points for CMMSE scores in elderly Chinese people of agricultural and rural Shanghai China Acta Neurol Scand 124(6):361-7
Gui YX, Wan Y, Xiao Q, Wang Y, Wang G, Chen SD （通讯作者） Verification of expressions of Kir2 as potential peripheral biomarkers in lymphocytes from patients with Parkinson's disease Neurosci Lett 505(2):104-8
Tian LP, Zhang S, Zhang YJ, Ding JQ, Chen SD （通讯作者） Lmx1b can promote the differentiation of embryonic stem cells to dopaminergic neurons associated with Parkinson's disease. Biotechnol Lett
Xin XY, Pan J, Wang XQ, Ma JF, Ding JQ, Yang GY, Chen SD （通讯作者） 2-methoxyestradiol attenuates autophagy activation after global ischemia Can J Neurol Sci 38(4):631-8
Jian-Fang Ma, Hong-Mei Wang, Qing-Yun Li, Yu Zhang, Jing Pan, Qiang Qiang, Xiao-Yu Xin, Hui-Dong Tang, Jian-Qing Ding, Sheng-Di Chen （通讯作者） Starvation triggers Aβ42 generation from human umbilical vascular endothelial cells FEBS Lett 584(14):3101-6
Pan J, Li H, Wang Y, Ma JF, Zhang J, Wang G, Liu J, Wang XJ, Xiao Q, Chen SD （通讯作者） Fibroblast growth factor 20 (FGF20) polymorphism is a risk factor for Parkinson's disease in Fibroblast growth factor 20 (FGF20) polymorphism is a risk factor for Parkinson's disease in Chinese population Parkinsonism Relat Disord
Wang G, Pan J, Chen SD （通讯作者） Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson’s disease Prog Neurobiol 98(2):207-21
Xu XH, Huang Y, Wang G, Chen SD （通讯作者） Metabolomics: a novel approach to identify potential diagnostic biomarkers and pathogenesis in Alzheimer's disease Neurosci Bull 28(5):641-8
Wang LL, Pan XL, Wang Y, Tang HD, Deng YL, Ren RJ, Xu W, Ma JF, Wang G, Shengdi Chen （通讯作者） A single nucleotide polymorphism in LRP2 is associated with susceptibility to Alzheimer's disease in the Chinese population Clin Chim Acta 412(3-4):268-70
Xiao-Guang Luo, Shengdi Chen （通讯作者） Microglia in the aging brain: relevance to neurodegeneration Mol Neurodegener
Ren RJ, Wang LL, Fang R, Liu LH, Wang Y, Tang HD, Deng YL, Xu W, Wang G, Chen SD （通讯作者） The MTHFD1L gene rs** marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population J Neurol Sci 308(1-2):32-4
Li Cao, Lan Zheng, Wei-Guo Tang, Qin Xiao, Ting Zhang, Hui-Dong Tang, Song-Bin He, Xi- Jin Wang, Jian-Qing Ding, Shengdi Chen （通讯作者） Four Novel Mutations in the GCH1 Gene of Chinese Patients with Dopa-Responsive Dystonia Movement Disorders 25(6):747-52
Ma JF, Liu LH, Zhang Y, Wang Y, Deng YL, Huang Y, Wang G, Xu W, Cui PJ, Fei QZ, Ding JQ, Tang HD, Chen SD （通讯作者） Association Study of Clusterin Polymorphism rs** With Late Onset Alzheimer's Disease in Chinese Han Population Am J Alzheimers Dis Other Demen 26(8):627-30
Cao L, Huang XJ, Zheng L, Xiao Q, Wang XJ, Chen SD （通讯作者） Identification of a novel PRRT2 mutation in patients with paroxysmal kinesigenic dyskinesias and c.649dupC as a mutation hot-spot Parkinsonism Relat Disord
Chen W, Tan YY, Hu YY, Zhan WW, Wu L, Lou Y, Wang X, Zhou Y, Huang P, Gao Y, Xiao Q, Chen SD （通讯作者） Combination of olfactory test and substantia nigra transcranial sonopraphy in the differential diagnosis of Parkinson's disease: a pilot study from China Transl Neurodegener 1(1):25
Ma JF, Wan Q, Hu XY, Sun SG, Wang WZ, Zhao ZX, Wang YJ, Liu CF, Li JM, Jiang YP, Chen SD （通讯作者） Efficacy and safety of pramipexole in chinese patients with restless legs syndrome: results from a multi-center, randomized, double-blind, placebo-controlled trial Sleep Med 13(1):58-63
Zhang S, Wang XJ, Tian LP, Pan J, Lu GQ, Zhang YJ, Ding JQ, Chen SD （通讯作者） CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease J Neuroinflammation
Wang LL, Huang Y, Wang G, Chen SD （通讯作者） The potential role of microRNA-146 in Alzheimer's disease: Biomarker or therapeutic target? Med Hypotheses 78(3):398-401
Yao YH, Xu RF, Tang HD, Jiang GX, Wang Y, Wang G, Shengdi Chen （通讯作者）,Cheng Q Cognitive Impairment and Associated Factors among the Elderly in the Shanghai Suburb: Findings from a Low-Education Population Neuroepidemiology 34(4):245-252
Hai-Yan Zhou, Yu-Yan Tan, Zhi-Quan Wang, Gang Wang, Guo-Qiang Lu, Shengdi Chen （通讯作者） Proteasome inhibitor lactacystin induces cholinergic degeneration Can J Neurol Sci 37(2):229-34
Liang Xu, Yu-Yan Tan, Jian-Qing Ding and Shengdi Chen The iPS technique provides hope for Parkinson's disease treatment Stem Cell Rev
Wu YW, Prakash KM, Rong TY, Li HH, Xiao Q, Tan LC, Au WL, Ding JQ, Shengdi Chen# （通讯作者）, Tan EK Lingo2 variants associated with essential tremor and Parkinson's disease Hum Genet 129(6):611-5
Cao L, Zhang T, Zheng L, Wang Y, Wang G,, Zhang J, Fei QZ, Cui PJ, Wang XJ, Ma JF, Xiao Q （通讯作者）, Shengdi Chen The GIGYF2 variants are not associated with Parkinson’s disease in the mainland Chinese population Parkinsonism Relat Disord 16(4):294-7
Chen W, Chen S, Xiao Q, Wang G, Chen SD （通讯作者） Current clinical practice for Parkinson's disease among Chinese physicians, general neurologists and movement disorders specialists: a national survey BMC Neurol 12(1):155
Liu J, Shi M, Hong Z, Zhang J, Bradner J, Quinn T, Beyer RP, Mcgeer PL, Shengdi Chen （通讯作者）, Zhang J Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by alpha-synuclein Proteomics 10(11): 2138-50
Cao L, Fei QZ, Tang WG, Liu JR, Zheng L, Xiao Q, He SB, Fu Y, Shengdi Chen （通讯作者） Novel mutations in the CYP7B1 gene cause hereditary spastic paraplegia Mov Disord 26(7):1354-6
Deng YL, Liu LH, Wang Y, Tang HD, Ren RJ, Xu W, Ma JF, Wang LL, Zhuang JP, Wang G, Chen SD （通讯作者） The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease Hum Genet
Wang G, Wan Y, Wang Y, Xiao Q, Liu J, Ma JF, Wang XJ, Zhou HY, Tan YY, Cheng Q, Shengdi Chen （通讯作者） Visual hallucinations and associated factors in Chinese patients with Parkinson's disease: roles of RBD and visual pathway deficit Parkinsonism Relat Disord 16(10):695-6
Luo XG, Zhang JJ, Zhang CD, Liu R （通讯作者）, Zheng L, Wang XJ, Shengdi Chen, Ding JQ Altered regulation of CD200 receptor in monocyte-derived macrophages from individuals with Parkinson's disease Neurochem Res 35(4):540-7
Gui YX, Wang XY, Kang WY, Zhang YJ, Zhang Y, Zhou Y （通讯作者）, Quinn TJ, Liu J, Chen SD Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1 Neurobiol Aging
Zhang Y, Chen S, Xiao Q, Cao L, Liu J, Rong TY, Ma JF, Wang G, Wang Y, Chen SD （通讯作者） Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease Parkinsonism Relat Disord 18(5):638-40
Zhang Y, Deng YL, Ma JF, Zheng L, Hong Z, Wang ZQ, Sheng CY, Xiao Q, Cao L, Shengdi Chen （通讯作者） Transthyretin-Related Hereditary Amyloidosis in a Chinese Family with TTR Y114C Mutation Neurodegener Dis
Zhao J, Tang H, Sun J, Wang B, Chen S （通讯作者）, Fu Y Analysis of cognitive dysfunction with silent cerebral infarction: a prospective study in Chinese patients Metab Brain Dis 27(1):17-22
Wu YW, Rong TY, Li HH, Xiao Q, Fei QZ, Tan EK, Ding JQ, Shengdi Chen （通讯作者） Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians Acta Neurol Scand
Pei-Jing Cui, Li Cao, Ying Wang, Yu-Lei Deng, Wei Xu ,Gang Wang, Yu Zhang, Lan Zheng, Qing-Zhou Fei and Shengdi Chen The Association Between Two SNPs of Insulin Degrading Enzyme and Alzheimer’s Disease in the Chinese Population J Clin Neurosci 19(5):745-9
Chen W, Chen S, Kang WY, Li B, Xu ZM, Xiao Q, Liu J, Wang Y, Wang G, Chen SD （通讯作者） Application of odor identification test in Parkinson's disease in China: A matched case-control study J Neurol Sci 316(1-2):47-50
Qing-Yun Li, Hong-Mei Wang, Zhi-Quan Wang, Jian-Fang Ma, Jian-Qing Ding, Shengdi Chen （通讯作者） Salidroside attenuates hypoxia-induced abnormal processing of β-amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells Neurosci Lett 481(3):154-8
Zhuang JP, Wang G, Cheng Q, Wang LL, Fang R, Liu LH, Xiong R, Zhang Y, Gui YX, Kang WY, Tang HD, Chen SD （通讯作者） Cognitive impairment and the associated risk factors among the elderly in the Shanghai urban area: a pilot study from China Transl Neurodegener 1(1):22
Xin Xiao-Yu, Ding Jian-Qing, Shengdi Chen （通讯作者） Apolipoprotein E promoter polymorphisms and risk of Alzheimer’s disease: evidence from meta-analysis J Alzheimer Disease 19(4):1283-94
Bin Liu, Yu Zhang, Ying Wang, Qin Xiao, Qiong Yang, Gang Wang, Jianfang Ma, Jing Zhao, Thomas J. Quinn, Sheng-di Chen （通讯作者）, Jun Liu Angiogenin variants are not associated with Parkinson’s disease in the ethnic Chinese population Parkinsonism Relat Disord
Tian LP, Zhang S, Xu L, Li W, Wang Y, Chen SD （通讯作者）, Ding JQ Selenite benefits embryonic stem cells therapy in Parkinson's disease Curr Mol Med 12(8):1005-14
Zhiquan Wang, Yu Zhang, Shi Zhang, Qianqian Guo, Yuyan Tan, Xinyi Wang, Ran Xiong, Jianqing Ding, Shengdi Chen （通讯作者） DJ-1 Can Inhibit Microtubule Associated Protein 1 B formed Aggregates Molecular Neurodegeneration 6:38
Wang G, Fan XN, Tan YY, Cheng Q, Chen Shengdi （通讯作者） Parkinsonism after chronic occupational exposure to glyphosate Parkinsonism Relat Disord 17(6):486-7
Ma JF, Xin XY, Liang L, Liu LH, Fang R, Zhang YJ, Wang DY, Fahn S, Tang HD, Chen SD （通讯作者） Restless legs syndrome in Chinese elderly people of an urban suburb in Shanghai: A community-based survey Parkinsonism Relat Disord 18(3):294-8
Chen S, Zhang Y, Chen W, Wang Y, Liu J, Rong TY, Ma JF, Wang G, Zhang J, Pan J, Xiao Q, Chen SD （通讯作者） Association study of SCARB2 rs** polymorphism with Parkinson's disease in Han Chinese. Neurosci Lett 516(1):21-3
Jiang TF, Chen SD （通讯作者） Dysfunction of two lysosome degradation pathways of α-synuclein in Parkinson's disease: potential therapeutic targets? Neurosci Bull 28(5):649-57
Cao L, Rong TY, Huang XJ, Fang R, Wu ZY, Tang HD, Chen SD （通讯作者） Novel SPG11 mutations in Chinese families with hereditary spastic paraplegia with thin corpus callosum Parkinsonism Relat Disord
Chen W, Xu ZM, Wang G, Chen SD （通讯作者） Non-motor symptoms of Parkinson's disease in China: A review of the literature Parkinsonism Relat Disord 18(5):446-52
Fei QZ, Tang WG, Rong TY, Tang HD, Liu JR, Guo ZL, Fu Y, Xiao Q, Wang XJ, He SB, Cao L, Chen SD （通讯作者） Two novel mutations in the Spastin gene of Chinese patients with hereditary spastic paraplegia Eur J Neurol 18(9):1194-6