导师姓名： 沈南 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属仁济医院 三级学科/
专业领域： 风湿病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： nanshensibs@gmail.com
邮编： 200001 邮箱地址： nanshensibs@gmail.com

研究方向 (点击浏览详细信息)
解析系统性红斑狼疮等自身免疫病的分子遗传机制并发展特异性免疫干预手段防止靶器官损害。

社会任职
亚太地区风湿病学联盟（APLAR）科学顾问委员会委员
International Jurnal of Rheumatic Diseases副主编
美国风湿病学会策划委员会（ ACR Annual Meeting Planning Committee）委员
红斑狼疮特别研究组共同主任（Co-Chair）
Faculty of 1000 Prime成员
Arthritis and Rheumatism 副主编
Clinical Rheumatology 编委
上海风湿病学会副主任委员
Scientific Report编委
上海免疫学会风湿免疫专业委员会主任委员
全国临床免疫学会委员
Clinical immunology 编委
中科院上海生命科学院/上海交通大学医学院健康科学研究所PI
Annals of Rheumatic Diseases编委
上海市风湿病学研究所所长
Arthritis Research & Therapy副主编
中国免疫学杂志 编委
国际红斑狼疮遗传学研究协作组（The International Consortium for the Genetics of Systemic Lupus Erythematosus, SLEGEN）成员
上海免疫学会副理事长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 狼疮遗传相关基因组非编码区介导免疫细胞亚群特异性调控的分子机制研究 国家自然基金重点项目 2020-01~2024-12 200万元 课题负责人
** 解析致病性TH17细胞分化及功能的表观遗传调控机制 国家自然基金重点项目 2017-01~2021-12 264万元 课题负责人
2014CB541900 系统性红斑狼疮的发病机理解析和诊治新策略硏究 国家973计划 2014-01~2018-08 3000万元 课题负责人
12JC** microRNA干预狼疮免疫病理损伤的机制及应用研究 上海市科委重点项目 2013-01~2015-12 50万元 课题负责人
** 系统解析microRNA 参与狼疮免疫病理损伤的细胞和分子机理 国家自然基金重点项目 2013-01~2017-12 280万元 课题负责人
** 系统性红斑狼疮的发病机理 国家自然基金****基金 2011-01~2014-12 200万元 课题负责人
10JC** microRNA精细调控浆细胞样树突状细胞表达干扰素分子机制的体外和体内研究 市科委基础研究重点 2010-10~2012-09 40万元 课题负责人
** miR-146a在系统性红斑狼疮中异常表达的机制及生物学功能研究 国家自然科学基金 2010-01~2012-12 30万元 课题负责人
08JC** MicroRNA调控红斑狼疮关键致病通路的作用机理研究 上海市科委，基础重点项目 2008-08~2010-09 50万元 课题负责人
2007AA02Z123 系统性红斑狼疮相关microRNA的鉴定及功能研究 国家科技部,863项目 2008-01~2010-12 100万元 课题负责人
07XD14021 系统性红斑狼疮干扰素通路异常激活的分子机制研究 上海市科委,学科带头人 2007-11~2009-11 35万元 课题负责人
06JC14050 应用功能基因组学研究策略解析狼疮致病通路 上海市科委,自然基金 2006-09~2008-08 20万元 课题负责人
** 中国人群染色体1q22-24区域狼疮易感基因鉴定及功能研究 国家自然基金委,面上项目 2005-01~2007-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
1.Chu-Xiao Liu#, Xiang Li#, Fang Nan#, Shan Jiang, Xiang Gao, Si-Kun Guo, Wei Xue, Yange Cui, Kaige Dong, Huihua Ding, Bo Qu, Zhaocai Zhou, Nan Shen* （通讯作者）, Li Yang*, Ling-Ling Chen* Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity Cell 2019 177: 1-16
Tang Y, Zhou T, Yu X, Xue Z, Shen N （通讯作者） The role of long non-coding RNAs in rheumatic diseases Nat Rev Rheumatol 2017 13(11):657-669
Jian Zhao#*, Jianyang Ma#, Yun Deng, Jennifer A Kelly, Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Quan-Zhen Li, Edward K Wakeland, Rong Qiu, Mengru Liu, Jianping Guo, Zhanguo Li, Wenfeng Tan, Astrid Rasmussen, Christopher J Lessard, Kathy L Sivils, Bevra H Hahn, Jennifer M Grossman, Diane L Kamen, Gary S Gilkeson, Sang-Cheol Bae, Patrick M Gaffney, Nan Shen* （通讯作者）, Betty P Tsao* A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases Nature genetics 2017 49(3): 433-437
Zhang F, Wu L, Qian J, Qu B, Xia S, La T, Wu Y, Ma J, Zeng J, Guo Q, Cui Y, Yang W, Huang J, Zhu W, Yao Y, Shen N （通讯作者）, Tang Y. Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus. J Autoimmun. 2016 pii: S0896-8411(16)30120-2. doi: 10.1016/j.jaut.2016.07.012. [Epub ahead of print]
Zhou S#, Wang Y#, Meng Y, Xiao C, Liu Z, Brohawn P, Higgs BW, Jallal B, Jia Q, Qu B, Huang X, Tang Y, Yao Y, Harley JB, Shen N*. （通讯作者） In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage. Arthritis Rheumatol. 2016 68(4):953-64.
Han X#, Wang Y#, Zhang X, Qin Y, Qu B, Wu L, Ma J, Zhou Z, Qian J, Dai M, Tang Y, Chan EK, Harley JB, Zhou S*, Shen N*. （通讯作者） MiR-130b ameliorates murine lupus nephritis through targeting type I interferon pathway on resident renal cells. Arthritis Rheumatol. 2016 doi: 10.1002/art.39725. [Epub ahead of print]
Wu L#, Qin Y#, Xia S#, Dai M, Han X, Wu Y, Zhang X, Ma J, Wang Y, Tang Y, Liu Z, Zhu W, Jallal B, Yao Y, Qu B*, Shen N*. （通讯作者） Identification of Cyclin-Dependent Kinase 1 as a Novel Regulator of Type I Interferon Signaling in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2016 68(5):1222-32.
Qu B, Cao J, Zhang F, Cui H, Teng J, Li J, Liu Z, Morehouse C, Jallal B, Tang Y, Guo Q, Yao Y, Shen N. （通讯作者） Type I interferon inhibits miR-146a maturation through upregulating MCPIP1 in systemic lupus erythematosus. Arthritis Rheumatol. 2015 67(12):3209-18
Wu Y, Zhang F, Ma J, Zhang X, Wu L, Qu B, Xia S, Chen S, Tang Y*, Shen N* （通讯作者） Association of large intergenic noncoding RNA expression with disease activity and organ damage in systemic lupus erythematosus Arthritis Res Ther. 2015 17:131
Song X, Dai D, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N* （通讯作者）, Qian Y* Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage immunity 2015 43(3):488-501
Zhang X, Han X, Tang Y, Wu Y, Qu B, Shen N. （通讯作者） miR-744 enhances type I interferon signaling pathway by targeting PTP1B in primary human renal mesangial cells. Sci Rep. 2015 5:12987
Pan W#, Zhu S#, Dai D#, Liu Z, Li D, Li B, Gagliani N, Zheng Y, Tang Y, Weirauch MT, Chen X7, Zhu W, Wang Y, Chen B, Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley JB, Flavell RA, Yao Y*, Shen N*. （通讯作者） MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis. Nat Commun 2015 6:7096
Qu B, Shen N. （通讯作者） miRNAs in the Pathogenesis of Systemic Lupus Erythematosus. Int J Mol Sci. 2015 16(5):955795-72.
Zhou XJ, Nath SK, Qi YY, Cheng FJ, Yang HZ, Zhang Y, Yang W, Ma JY, Zhao MH, Shen N* （通讯作者）, Zhang H* Identification of MTMR3 as a Novel Susceptibility Gene for Lupus Nephritis in Northern Han Chinese by Shared-Gene Analysis With IgA Nephropathy Arthritis Rheumatol 2014 66(10):2842-8
Qin H, Guo Q*, Shen N* （通讯作者）, Huang X, Wu H, Zhang M, Bao C, Chen S. Chest imaging manifestations in lupus nephritis. Clin Rheumatol. 2014 33(6):817-23.
Zhou ZY, Chen SL, Shen N （通讯作者）, Lu Y. Cytokines and Behcet's Disease. Autoimmun Rev. 2012 11(10):699-704.
Liang D, Shen N. （通讯作者） MicroRNA involvement in lupus: the beginning of a new tale. Curr Opin Rheumatol. 2012 24(5):489-98.
Zhu S, Pan W, Song X, Liu Y, Tang Y, Wang H, Liu W, Shi Y, He D, Harley JB, Shen N （通讯作者）, Qian Y 2012, A Novel Vector-Based Method for MiR-23b suppresses IL-17 associated autoimmune pathogenesis. Nature medicine. 2012 18(7):1077-1086
Shen N （通讯作者）, Liang D, Tang Y, de Vries N, Tak PP. MicroRNAs—novel regulators of systemic lupus erythematosus pathogenesis Nat Rev Rheumatol. 2012 8(12):701-9.
Fan W, Liang D, Tang Y, Qu B, Cui H, Luo X, Huang X, Chen S, Higgs BW, Jallal B, Yao Y, Harley JB, Shen N. （通讯作者） Identification of microRNA-31 as a novel regulator contributing to impaired IL-2 production in T cells from patients with systemic lupus erythematosus. Arthritis Rheum. 2012 64(11):3715-25
Qu B, Han X, Tang Y, Shen N. （通讯作者） A Novel Vector-Based Method for Exclusive Overexpression of Star-Form MicroRNAs. PLoS One. 2012 7(7)e41504:1-10.
Liao LH, Zhang H, Lai MP, Chen SL, Wu M, Shen N* （通讯作者） Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population Arthritis Res Ther 2011 13(1):11-11
Wang S, Tang Y, Cui H, Zhao X, Luo X, Pan W, Huang X, Shen N* （通讯作者） Let-7/miR-98 regulate Fas and Fas-mediated apoptosis Genes Immun 2011 12(2):149-54
Li J, Fu Q, Cui H, Qu B, Pan W, Shen N*, Bao C* Interferon-α Priming Promotes Lipid Uptake and Macrophage-Derived Foam Cell Formation: A Novel Link between Interferon-α and Atherosclerosis in Lupus. Arthritis Rheum 2011 63(2):492-502
Fu Q, Zhao J, Qian X, Wong JL, Kaufman KM, Yu CY; Hwee Siew Howe; Tan Tock Seng Hospital Lupus Study Group, Mok MY, Harley JB （通讯作者）, Guthridge JM, Song YW, Cho SK, Bae SC, Grossman JM, Hahn BH, Arnett FC, Shen N, Tsao BP* Association of a functional IRF7 variant with systemic lupus erythematosus Arthritis Rheum 2011 63(3):749-54
Xiaobing Luo, Wanling Yang, Dong-Qing Ye, Huijuan Cui, Yan Zhang, Nattiya Hirankarn,Xiaoxia Qian, Yuanjia Tang, Yu Lung Lau, Niek de Vries, Paul Peter Tak, Betty P. Tsao, Nan Shen A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus PLoS Genet 2011 7 (6): **
Yang W, Shen N, Ye DQ, Liu Q, Zhang Y, Qian XX, Hirankarn N, Ying D, Pan HF, Mok CC, Chan TM, Wong RW, Lee KW, Mok MY, Wong SN, Leung AM, Li XP, Avihingsanon Y, Wong CM, Lee TL, Ho MH, Lee PP, Chang YK, Li PH, Li RJ, Zhang L, Wong WH, Ng IO, Lau CS, Sham Asian Lupus Genetics Consortium. Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus PLoS Genet 2010 6(2)
Maiti AK, Kim-Howard X, Viswanathan P, Guillén L, Qian X, Rojas-Villarraga A, Sun C, Ca?as C, Tobón GJ, Matsuda K, Shen N, Cher?avsky AC, Anaya JM, Nath SK Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases Rheumatology (Oxford) 2010 49(7):1239-44
Luo X, Tsai LM, Shen N, Yu D Evidence for microRNA-mediated regulation in rheumatic diseases Ann Rheum Dis 2010
Zhou H, Huang X, Cui H, Luo X, Tang Y, Chen S, Wu L, Shen N* miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells Blood 2010 116(26): 5885-5894
Pan W, Zhu S, Yuan M, Cui H, Wang L, Luo X, Li J, Zhou H, Tang Y, Shen N* MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1 J Immunol 2010 184(12):6773-81
Shen N*, Fu Q, Deng Y, Qian X, Zhao J, Kaufman KM, Wu YL, Yu CY, Tang Y, Chen JY, Yang W, Wong M, Kawasaki A, Tsuchiya N, Sumida T, Kawaguchi Y, Howe HS, Mok MY, Bang SY, Liu FL, Chang DM, Takasaki Y, Hashimoto H, Harley JB, Guthridge JM, Grossman JM, Can Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus Proc Natl Acad Sci(USA) 2010 107(36):15838-15843
Zhao X, Tang Y, Qu B, Cui H, Wang S, Wang L, Luo X, Huang X, Li J, Chen S, Shen N* MicroRNA-125a contributes to elevated inflammatory chemokine RANTES via targeting KLF13 in systemic lupus erythematosus Arthritis Rheum 2010 62 (11):3425-3435
Tang YJ, Luo XB, Cui HJ, Ni XM, Yuan M, Guo YZ, Huang XF, Zhou HB, Vries N, Tak P, Chen SL, Shen N* MicroRNA-146a Contributes to Abnormal Activation of the Type I Interferon Pathway in Human Lupus by Targeting the Key Signaling Proteins Arthritis Rheum 2009 60(4):1065-75
Yan B, Ye S*, Chen GJ, Kuang M, Shen N*, Chen SL Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells Arthritis Rheum 2008 58(3):801-12
Tang J, Gu Y, Zhang M, Ye S, Chen X, Guo Q, Qian J, Bao C, Chen S, Shen N* Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients Lupus 2008 17(9):805-13
Huang XY, Shen N*, Bao CD, Gu YY, Wu L, Chen SL Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells Arthritis Res Ther 2008 10(4):R91
Fu Q, Chen XQ, Cui HJ, Guo YZ, Chen J, Shen N*, Bao CD* Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients Arthritis Res Ther 2008 10(5)
Du F, Lü LJ, Fu Q, Dai M, Teng JL, Fan W, Chen SL, Ye P, Shen N, Huang XF, Qian J, Bao CD T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis Arthritis Rheum 2008 10(6)
Feng XG, Ye S, Lu Y, Xu XJ, Gu YY, Shen N, Ye P, Cheng FP, Wang AM, Chen SL Antikinectin autoantibody in Beh?et's disease and several other autoimmune connective tissue diseases Clin Exp Rheumatol 2007 25(445):80-5.
Huang XF,Hua J,Shen N,Chen SL Ysregulated expression of interleukin-23 and interleukin-12 subunits in systemic lupus erythematosus patients Modern Rheumatology 2007 17(3):220-223
Lu Q, Shen N*, Li XM, Chen SL Genomic view of IFN-alpha response in pre-autoimmune NZB/W and MRL/lpr mice Genes Immun 2007 8(7):590-603
Wu H, Boackle SA, Hanvivadhanakul P, Ulgiati D, Grossman JM, Lee Y, Shen N, Abraham LJ, Mercer TR, Park E, Hebert LA, Rovin BH, Birmingham DJ, Chang DM, Chen CJ, McCurdy D, Badsha HM, Thong BY, Chng HH, Arnett FC, Wallace DJ, Yu CY, Hahn BH, Cantor RM, Ts Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus Proc Natl Acad Sci U S A 2007 104 (10):3961-6
Ye S,Guo Q,Tang JP, Yang CD, Shen N, Chen SL Could 2'5'-oligoadenylate synthetase isoforms be biomarkers to differentiate between disease flare and infection in lupus patients? A pilot study Clin Rheumatol 2007 26(2):186-90
Shen N, Tsao BP Current advances in the human lupus genetics Curr Rheumatol 2004 6(5):391-8
Feng XB, Shen N, Qian J, Sun L, Hua J, Chen SL Single nucleotide polymorphisms of deoxyribonuclease I and their expression in Chinese systemic lupus erythematosus patients Chin Med J (Engl) 2004 117(11):1670-6
Lu LJ, Chen SL, Gu YY, Shen N, Bao CD, Wang Y, Xue F, Ye P, Yu CZ Transfection, overexpression and clinical application of human 60 kDa Ro/SSA autoantigens in HEp-2 cells Chin Med J (Engl) 2003 116(3):350-3
Han GM, Chen SL, Shen N, Ye S, Bao CD, Gu YY Analysis of gene expression profiles in human systemic lupus erythematosus using oligonucleotide microarray Genes Immun 2003 4(3):177-86
Ye S, Pang H, Gu YY, Hua J, Chen XG, Bao CD, Wang Y, Zhang W, Qian J, Tsao BP, Hahn BH, Chen SL, Rao ZH, Shen N* Protein interaction for an interferon-inducible systemic lupus associated gene,IFIT1 Rheumatology (Oxford) 2003 42(10):1155-63
Tsao BP, Cantor RM, Grossman JM, Kim SK, Strong N, Lau CS, Chen CJ, Shen N, Ginzler EM, Goldstein R, Kalunian KC, Arnett FC, Wallace DJ, Hahn BH Linkage and interaction of loci on 1q23 and 16q12 may contribute to susceptibility to systemic lupus erythematosus Arthritis Rheum 2002 46(11):2928-36
Chen SL, Hu DW, Shi XG, Shen N, Gu YY, Bao CD The relationship between Th1/Th2-type cells and disease activity in patients with systemic lupus erythematosus Chin Med J (Engl) 2000 113(10):877-80
Tsao BP, Cantor RM, Grossman JM, Shen N, Teophilov NT, Wallace DJ, Arnett FC, Hartung K, Goldstein R, Kalunian KC, Hahn BH, Rotter JI PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus J Clin Invest 1999 103(8):1135-40
Shen N, Chen S, Yang H, Fan L Mixed connective tissue disease: a disease entity? Chin Med J (Engl) 1998 111(3):214-7
Yang CD, Chen SL, Shen N, Qi M, Xu F Detection of anti-recombinant beta 2-glycoprotein 1 and anti-recombinant beta 2-glycoprotein 1 fifth-domain antibodies in sera from patients with systemic lupus erythematosus Rheumatol Int 1998 18(1):5-10
Tsao BP, Cantor RM, Kalunian KC, Chen CJ, Badsha H, Singh R, Wallace DJ, Kitridou RC, Chen SL, Shen N, Song YW, Isenberg DA, Yu CL, Hahn BH, Rotter JI Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus J Clin Invest 1997 99(4):725-31
Yang CD, Chen SL, Shen N The Fifth Domain of β2-Glycorprotein 1 Contain Antigenic Epitopes Recognized by Anticardiolipin Antibodies Derived From Patients With The Antipholipid Syndrome APLAR Journal of Rheumatology 1997 1(1):96-100