导师姓名： 唐茹琦 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属仁济医院 三级学科/
专业领域： 消化系病
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： ruqi_tang@126.com

研究方向 (点击浏览详细信息)
自身免疫性肝病

社会任职
中国医促会消化病学分会肠微生态学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 自身免疫性肝病发病机制研究 国家自然科学基金优秀青年项目 2020-01~2022-12 120万元 课题负责人
** 原发性胆汁性胆管炎相关肠道菌群通过调控肠道滤泡辅助性T细胞影响肝脏免疫微环境的机制研究 国家自然科学基金面上项目 2019-01~2022-12 57万元 课题负责人
Interplay of host genetics and gut microbiota in Primary Biliary Cholangitis Gilead Sciences Research Scholars Program in Liver Disease – Asia 2018-03~2020-03 90万元 课题负责人
** 上海交通大学医学院高原高峰计划 上海市教委 2016-07~2019-06 100万元 课题负责人
** 原发性胆汁性肝硬化易感基因RANK/RANKL致病位点的探索和功能研究 国家自然科学基金面上项目 2016-01~2019-12 57万元 课题负责人
** CTHRC1基因遗传多态性与原发性胆汁性肝硬化的相关性研究及其功能鉴定 国家自然科学基金青年项目 2015-01~2017-12 23万元 课题负责人
YG2014MS43 基于高通量数据的原发性胆汁性肝硬化遗传风险预测模型探索 上海交通大学医工交叉面上项目 2015-01~2017-12 15万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chen W, Wei Y, Xiong A, Li Y, Guan H, Wang Q, Miao Q, Bian Z, Xiao X, Lian M, Zhang J, Li B, Cao Q, Fan Z, Zhang W, Qiu D, Fang J, Gershwin ME, Yang L*, Tang R* （通讯作者）, Ma X*. Comprehensive Analysis of Serum and Fecal Bile Acid Profiles and Interaction with Gut Microbiota in Primary Biliary Cholangitis Clin Rev Allergy Immunol 2020 58(1):25-38
Wei Y, Li Y, Yan L, Sun C, Miao Q, Wang Q, Xiao X, Lian M, Li B, Chen Y, Zhang J, Li Y, Huang B, Li Y, Cao Q, Fan Z, Chen X, Fang JY, Gershwin ME, Tang R* （通讯作者）, Ma X*. Alterations of gut microbiome in autoimmune hepatitis Gut 2020 69(3):569-577
Li Y, Li B, You Z, Zhang J, Wei Y, Li Y, Chen Y, Huang B, Wang Q, Miao Q, Peng Y, Fang J, Gershwin ME*, Tang R* （通讯作者）, Greenberg SA*, Ma X*. Cytotoxic KLRG1 expressing lymphocytes invade portal tracts in primary biliary cholangitis J Autoimmun 2019 103:102293
Li Y, Huang B, Jiang X, Chen W, Zhang J, Wei Y, Chen Y, Lian M, Bian Z, Miao Q, Peng Y, Fang J, Wang Q, Tang R* （通讯作者）, Gershwin ME*, Ma X*. Mucosal-Associated Invariant T Cells Improve Nonalcoholic Fatty Liver Disease Through Regulating Macrophage Polarization Frontiers in Immunology 2018 9:1994
Lian M, Wang Q, Jiang X, Zhang J, Wei Y, Li Y, Li B, Chen W, Zhang H, Miao Q, Peng Y, Xiao X, Sheng L, Zhang W, Fang J, Tang R* （通讯作者）, Gershwin ME*, Ma X* The Immunobiology of RANKL and Myeloid Derived Suppressor Cell Activation in IgG4-related Sclerosing Cholangitis Hepatology 2018 68(5):1922-1936
Jiang X, Lian M, Li Y, Zhang W, Wang Q, Wei Y, Zhang J, Chen W, Xiao X, Miao Q, Bian Z, Qiu D, Fang J, Ansari AA, Leung PSC, Coppel RL, Tang R* （通讯作者）, Gershwin ME*, Ma X* The immunobiology of mucosal-associated invariant T cell (MAIT) function in primary biliary cholangitis: Regulation by cholic acid-induced Interleukin-7 Journal of Autoimmunity 2018 90:64-75
Tang R#* （通讯作者）, Wei Y#, Li Y#, Chen W, Chen H, Wang Q, Yang F, Miao Q, Xiao X, Zhang H, Lian M, Jiang X, Zhang J, Cao Q, Fan Z, Wu M, Qiu D, Fang JY, Ansari A, Gershwin ME*, Ma X* Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy. Gut 2018 67(3):534-541
Qiu F#, Tang R# （共同第一作者）, Zuo X#, Shi X#, Wei Y#, Zheng X#, Dai Y, Gong Y, Wang L, Xu P, Zhu X, Wu J, Han C, Gao Y, Zhang K, Jiang Y, Zhou J, Shao Y, Hu Z, Tian Y, Zhang H, Dai N, Liu L, Wu X, Zhao W, Zhang X, Zang Z, Nie J, Sun W, Zhao Y, Mao Y, Jiang P, Ji H, Dong Q, Li J, Li Z, Bai X, Li L, Lin M, Dong M, Li J, Zhu P, Wang C, Zhang Y, Jiang P, Wang Y, Jawed R, Xu J, Zhang Y, Wang Q, Yang Y, Yang F, Lian M, Jiang X, Xiao X, Li Y, Fang J, Qiu D, Zhu Z, Qiu H, Zhang J, Tian W, Chen S, Jiang L, Ji B, Li P, Chen G, Wu T, Sun Y, Yu J, Tang H, He M, Xia M, Pei H, Huang L, Qing Z, Wu J, Huang Q, Han J, Xie W, Sun Z, Guo J, He G, Eric Gershwin M, Lian Z, Liu X, Seldin MF, Liu X*, Chen W*, Ma X* A genome-wide association study identifies six novel risk loci for primary biliary cholangitis. Nature Communications 2017 8:14828
Li Y#, Tang R# （共同第一作者）, Leung PSC, Gershwin ME*, Ma X* Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases. Autoimmun Rev. 2017 16(9):885-896
Yang F#, Yang Y#, Wang Q, Wang Z, Miao Q, Xiao X, Wei Y, Bian Z, Sheng L, Chen X, Qiu D, Fang J, Tang R* （通讯作者）, Gershwin ME*, Ma X* The risk predictive values of UK-PBC and GLOBE scoring system in Chinese patients with primary biliary cholangitis: the additional effect of anti-gp210. Alimentary Pharmacology & Therapeutics 2017 45:733-743
Tang R#, Wei Y#, Li Z#, Chen H, Miao Q, Bian Z, Zhang H, Wang Q, Wang Z, Lian M, Yang F, Jiang X, Yang Y, Li E, Seldin MF, Gershwin ME*, Liao W*, Shi Y, Ma X* A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density Scientific Reports 2016 6:19877
Bian Z#, Miao Q#, Zhong W#, Zhang H, Wang Q, Peng Y, Chen X, Guo C, Shen L, Yang F, Xu J, Qiu D, Fang J, Friedman S, Tang R* （通讯作者）, Gershwin ME*, Ma X* Treatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease Journal of Autoimmunity 2015 63:76-87
Tang R#, Chen H#, Miao Q, Bian Z, Ma W, Feng X, Seldin MF, Invernizzi P, Gershwin ME*, Liao W*, Ma X* The cumulative effects of known susceptibility variants to predict primary biliary cirrhosis risk. Genes and Immunity 2015 16(3):238
Dong M#,Li J#,Tang R# （共同第一作者）, Zhu P, Qiu F, Wang C, Qiu J, Wang L, Dai Y, Xu P, Gao Y, Han C, Wang Y, Wu J, Wu X, Zhang K, Dai N, Sun W, Zhou J, Hu Z, Liu L, Jiang Y, Nie J, Zhao Y, Gong Y, Tian Y, Ji H, Jiao Z, Jiang P, Shi X, Jawed R, Zhang Y, Huang Q, Li E, Wei Y, Xie W, Zhao W, Liu X, Zhu X, Qiu H, He G, Chen W, Seldin MF, Gershwin ME*, Liu X*, Ma X* Multiple Genetic Variants Associated with Primary Biliary Cirrhosis in a Han Chinese Population. Clin Rev Allergy Immunol 2015 48(2-3):316-21
Tang R#, Noh HJ#, Wang D, Sigurdsson S, Swofford R, Perloski M, Duxbury M, Patterson EE, Albright J, Castelhano M, Auton A, Boyko AR, Feng G, Lindblad-Toh K*, Karlsson EK* Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder Genome Biology 2014 15(3): R25