导师姓名： 冉志华 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属仁济医院 三级学科/
专业领域： 消化系病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市浦建路160号，仁济医院消化科
邮编： 200127 邮箱地址： zhihuaran@vip.163.com

研究方向 (点击浏览详细信息)
炎症性肠病基础与临床研究

社会任职
中国大陆首位国际炎症性肠病委员，金砖国家炎症性肠病联盟(BRICS IBD Consortium)创始人兼首任主席，欧洲克罗恩病和结肠炎组织（ECCO）科学委员会评委，国际健康结果评估组织（ICHOM）炎症性肠病协作组成员，亚洲克罗恩病和结肠炎组织（AOCC）教育委员会主席，中华医学会消化病学分会炎症性肠病学组副组长，上海市医学会消化病学分会委员兼炎症性肠病学组组长，中华医学会消化病学分会营养支持学组副组长，中华医学科技进步奖第二届评审委员会委员，国家自然科学基金委同行评审专家, J Gastroenterology and Hepatology Open、Inflammatory Intestinal Disease副主编，《《中华炎性杂志》副总编辑、中华消化杂志》、《胃肠病学》、《国际消化病学》等杂志编委, 为《British Medical journal》、《Gastroenterology》、《Alimentary Pharmacology & Therapeutics》、《Journal of Clinical Pharmacy and Therapeutics》、《Journal of Gastroenterology and Hepatology》、《Journal of Cellular Biochemistry》、《Digestive Diseases and Sciences》、《Cancer Chemotherapy Pharmacology》、《European Journal of Cancer Care》、《International Journal of Cancer》、《European Journal of Pharmacology》、《Chinese Medical Journal》等12本SCI、3本中文杂志特约审稿人。
担任上海市炎症性肠病研究中心主任、上海市消化疾病研究所副所长、卫生部内科消化重点实验室副主任、仁济医院消化科副主任

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 肠道共生菌调控3型先天淋巴细胞影响溃疡性结肠炎黏膜愈合的机制研究 国家自然科学基金 2017-01~2020-12 55万元 课题负责人
** FZD7/NFATc1转录活性调控溃疡性结肠炎中传统型／非传统型肠上皮内淋巴细胞免疫平衡的机制 国家自然基金委，面上项目 2014-01~2017-12 70万元 主要责任人
** 克罗恩病基于分化动力学平衡偏移的CREB相关长链非编码RNA变异机制研究 国家自然基金委 2012-01~2015-12 55万元 课题负责人
10XD** DNA拷贝数变异与克罗恩病的关联研究 上海市科委优秀学科带头人 2010-04~2012-03 40万元 主要责任人
RJ** 炎症性肠病诊治学科群 仁济医院学科建设 2010-01~2012-12 50万元 主要责任人
中国炎症性肠病易感基因的筛选与临床研究 卫生部行业基金 2008-01~2010-12 17万元 子课题负责人
** miRNA在人结肠癌细胞羟基喜树碱多药耐药中的作用初探 国家自然基金委,面上项目 2008-01~2010-12 30万元 课题负责人
** HRP蛋白在人结肠癌多药耐药过程中的作用及其分子机制研究 国家自然基金委,面上项目 2007-01~2009-12 8万元 课题负责人
06DZ22027 人结肠多耐药机制及耐药逆转研究 上海市科委,重点实验室 2007-01~2009-12 40万元 课题负责人
2002-17 Investigation of the relationship between differentiation state of gastric cancer and their susceptibility to parvovirus H-1 induced killing 上海市科委白玉兰基金 2002-09~2003-03 1万元 课题负责人
交流项目 The role of MAPK signaling pathways in parvovirus oncolytic activity 第五届中德生物技术合作项目 2002-07~2004-06 0万元 课题负责人
胃癌细胞分化状态与细小病毒毒性作用相关性的研究 国家教委青年骨干项目 2000-01~2002-12 12万元 课题负责人
grant I/75 890 Investigation of the relationship between differentiation state of gastric cancer and their susceptibility to parvovirus H-1 induced killing 德国大众基金会 2000-01~2002-12 100万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wu B, Tong J, Ran Z （通讯作者） Tacrolimus Therapy in Steroid-Refractory Ulcerative Colitis: A Review Inflamm Bowel Dis 2020 1;26(1):24-32
Xu Y, Shen J, Ran Z （通讯作者） Emerging views of mitophagy in immunity and autoimmune diseases Autophagy 2020 16(1):3-17
Dai ZH, Xu XT, Ran ZH （通讯作者） Associations Between Obesity and the Effectiveness of Anti-Tumor Necrosis Factor-α Agents in Inflammatory Bowel Disease Patients: A Literature Review and Meta-analysis. Ann Pharmacother. 2020 19:00660.
Danese S, Ran ZH, Repici A, Tong J, Omodei P, Aghemo A, Malesci A Gastroenterology department operational reorganisation at the time of covid-19 outbreak: an Italian and Chinese experience Gut 2020 69(6):981-983
Zhang QW, Shen J, Zheng Q, Ran ZH Loss of response to scheduled infliximab therapy for Crohn's disease in adults: A systematic review and meta-analysis. J Dig Dis 2019 20(2):65-72
Mak JWY, Tang W, Yip TCF, Ran ZH, Wei SC, Ahuja V, Kumar S, Leung WK, Hilmi I, Limsrivilai J, Aniwan S, Lam BCY, Chan KH, Ng KM, Leung CM, Li MKK, Lo FH, Sze ASF, Tsang SWC, Hui AJ, Hartono JL, Ng SC Stopping anti-tumour necrosis factor therapy in patients with perianal Crohn's disease. Aliment Pharmacol Ther. 2019 50(11-12):1195-1203
Lai LJ, Shen J, Ran ZH （通讯作者） Natural killer T cells and ulcerative colitis Cell Immunol 2019 335:1-5
Qiao YQ, Cai CW, Shen J, Zheng Q, Ran ZH （通讯作者） Circular RNA expression alterations in colon tissues of Crohn‘s disease patients. Mol Med Rep. 2019 19(5):4500-4506
Yun Cui , Shi-Yuan Lu, Jie Xu, Yan-Shen Peng , Qi Miao , Xiao-Qing Wang , Xiao-Yu Chen, Zhi-Hua Ran （通讯作者） Microscopic Features of Small Bowel Mucosa of Patients With Crohn's Disease BMC Gastroenterol 2019 19 (1), 232
Ooi CJ, Hilmi I, Banerjee R, Chuah SW, Ng SC, Wei SC, Makharia GK, Pisespongsa P, Chen MH, Ran ZH, Ye BD, Park DI, Ling KL, Ong D, Ahuja V, Goh KL, Sollano J, Lim WC, Leung WK, Raja Ali RA, Wu DC, Ong E, Mustaffa N, Limsrivilai J, Hisamatsu T, Yang SK, Ouyang Q, Geary R, De Silva JH, Rerknimitr R, Simadibrata M, Abdullah M, Leong RWL Asia Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease and Asian Organization for Crohn's and Colitis. Best practices on immunomodulators and biological agents for Ulcerative colitis and Crohn's disease in Asia. J Gastroenterol Hepatol 2019 34 (8), 1296-1315
Qiao Y, Ran Z （通讯作者） Potential influential factors on incidence and prevalence of inflammatory bowel disease in mainland China J Gastroenterol Hepatol Open 2019 6;4(1):11-15
Andrew H Kim, Charlotte Roberts, Brian G Feagan, Rupa Banerjee, Willem Bemelman, Keith Bodger, Marc Derieppe, Axel Dignass, Richard Driscoll, Ray Fitzpatrick, Janette Gaarentstroom-Lunt, Peter D Higgins, Paulo Gustavo Kotze, Jillian Meissner, Marian O’Connor, Zhi-Hua Ran, Corey A Siegel, Helen Terry, Welmoed K van Deen, C.Janneke van der Woude, Alandra Weaver, Suk-Kyun Yang, Bruce E Sands, Séverine Vermeire, and Simon PL Developing a Standard Set of Patient-Centred Outcomes for Inflammatory Bowel Disease – an International, Cross-disciplinary Consensus J Crohns Colitis 2018 12(4):408-418
Feng Q, Xu XT, Zhou Y, Yan YQ, Ran ZH, Zhu J Creeping fat in patients with ileo-colonic Crohn's disease correlates with disease activity and severity of inflammation: A preliminary study using energy spectral computed tomography J Dig Dis 2018 19(8):475-484
Qian X, Wang T, Shen J, Ran Z （通讯作者） Low dose of azathioprine is effective to induce and maintain remission in active Crohn disease: A prospective observational study Medicine (Baltimore) 2018 97(34):e11814
Park DI, Hisamatsu T, Chen M, Ng SC, Ooi CJ, Wei SC, Banerjee R, Hilmi IN, Jeen YT, Han DS1, Kim HJ, Ran Z, Wu K, Qian J, Hu PJ, Matsuoka K, Andoh A, Suzuki Y, Sugano K, Watanabe M, Hibi T, Puri AS, Yang SK Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Park 1: risk assessment J Gastroenterol Hepatol 2018 33(1):20-29
Wang TR, Qiao YQ, Zou DW, Ran ZH （通讯作者） A single-center experience with methotrexate in the treatment of Chinese Crohn's disease patients J Dig Dis 2018 19(12):753-758.
Park DI, Hisamatsu T, Chen M, Ng SC, Ooi CJ, Wei SC, Banerjee R, Hilmi IN, Jeen YT, Han DS, Kim HJ, Ran Z, Wu K, Qian J, Hu PJ, Matsuoka K, Andoh A, Suzuki Y, Sugano K, Watanabe M, Hibi T, Puri AS, Yang SK Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 2: management J Gastroenterol Hepatol 2018 33(1):30-36
15.Jiang H, Shen J, Ran Z. （通讯作者） Epithelial-mesenchymal transition in Crohn's disease Mucosal Immunol 2018 11(2):294-303
Lu JT, Xu AT, Shen J, Ran ZH （通讯作者） Crosstalk Between Intestinal Epithelial Cell and Adaptive Immune Cell in Intestinal Mucosal Immunity J Gastroenterol Hepatol 2017 May;32(5):975-980
Huang S, Ma J, Zhu M, Ran Z （通讯作者） Status of serum vitamin B12 and folate in patients with inflammatory bowel disease in China Intest Res 2017 Jan;15(1):103-108
Zhao D, Cai C, Zheng Q, Jin S, Song D, Shen J, Ran Z （通讯作者） Vancomycin pre-treatment impairs tissue healing in experimental colitis: Importance of innate lymphoid cells. Biochem Biophys Res Commun 2017 Jan 29;483(1):237-244
Jin S, Zhao D, Cai C, Song D, Shen J, Xu A, Qiao Y, Ran Z （通讯作者）, Zheng Q Low-dose penicillin exposure in early life decreases Th17 and the susceptibility to DSS colitis in mice through gut microbiota modification Sci Rep 2017 Mar 8;7:43662
Song D, Tong J, Peng J, Cai C, Xu X, Zhu M, Ran Z, Zheng Q Tuberculosis screening using IGRA and chest computed tomography in patients with inflammatory bowel disease: a retrospective study J Dig Dis 2017 Jan;18(1):23-30
Qian XX, Peng JC, Xu AT, Zhao D, Qiao YQ, Wang TR, Shen J, Ran ZH （通讯作者） Non-coding Transcribed Ultraconserved Region (T-UCR) uc.261 Participates in Intestinal Mucosa Barrier Damage in Crohn’s Disease Inflamm Bowel Dis 2016 Dec;22(12):2840-2852
Ma JY, Tong JL, Ran ZH （通讯作者） Intestinal tuberculosis and Crohn's disease: Challenging Differential Diagnosis J Dig Dis 2016 2016 Mar;17(3):155-61
Li X, Shen J, Ran Z （通讯作者） Crosstalk between the gut and the liver via susceptibility loci: Novel advances in inflammatory bowel disease and autoimmune liver disease Clin Immunol 2016 Oct 21. pii: S1521-6616(16)30303-5.
Ze Lan Lu*,Tian Rong Wang*, Yu Qi Qiao, Qing Zheng, Ying Sun, Jun Tao Lu, Xiao Xiao Han, Zhu Ping Fan, Zhi Hua Ran （通讯作者） Handgrip Strengh Index Predicts Nutritional Status as a Complement to BMI in Crohn’s Disease J Crohns Colitis. 2016 Dec;10(12):1395-1400
Xu AT, Tong JL, Ran ZH （通讯作者） Organoids Derived from Digestive tract, liver, and pancreas J Dig Dis 2016 2016 Jan;17(1):3-10
Qiao YQ, Cai CW, Ran ZH （通讯作者） Therapeutic Modulation of the Gut Microbiota in IBD - More Questions to Be Answered J Dig Dis 2016 Dec;17(12):800-810.
Xu AT, Lu JT, Ran ZH* （通讯作者）, Zheng Q Exosome in Intestinal Mucosal Immunity J Gastroenterol Hepatol 2016 Oct;31(10):1694-1699
Peng JC, Feng Q, Zhu J, Shen J, Qiao YQ, Xu JR, Ran ZH （通讯作者） Usefulness of spectral computed tomography for evaluation of intestinal activity and severity in ileocolonic Cronh’s disease Therap Adv Gastroenterol 2016 Nov;9(6):795-805.
Xu AT, Li Y, Zhao D, Shen J, Xu XT, Qiao YQ, Zhu MM, Wang TR, Cui Y, Ai LY, Ran ZH （通讯作者） High Suppressor of Cytokine Signaling-3 Expression Impairs STAT3-dependent Protective Effects of Interleukin-22 in Ulcerative Colitis in Remission Inflamm Bowel Dis 2015 2015 Feb;21(2):241-50
Cao Y, Zhao D, Xu AT, Shen J, Ran ZH （通讯作者） Effects of Immunosuppressants on Immune Response to Vaccine in Inflammatory Bowel Disease Chin Med J 2015 2015;128(6):835-838
Qiao YQ, Huang ML, Zheng Q, Wang TR, Xu AT, Cao Y, Zhao D, Ran ZH （通讯作者）, Shen J CNTNAP3 Associated ATG16L1 Expression and Crohn's Disease Mediators Inflamm 2015 404185. doi: 10.1155/2015/404185. Epub 2015 Mar 26
Tong JL, Zheng Q, Zhang C, Lo R, Shen J, Ran ZH （通讯作者） Incidence, Prevalence, and Temporal Trend of Microscopic Colitis: a Systematic Review and Meta-Analysis Am J Gastroenterol 2015 2015;110(2):265-276
Peng JC1, Zhong L, Ran ZH （通讯作者） Primary Lymphomas in the Gastrointestinal Tract J Dig Dis 2015 16(4):169-76
Peng JC, Shen J, Zhu Q, Ran ZH （通讯作者） The impact of Clostridum difficile on surgical rate among ulcerative colitis patients: A systemic review and meta-analysis Saudi J Gastroentero 2015 2015 Jul-Aug;21(4):208-12
Tong JL, Zheng Q, Zhang C, Lo R, Shen J, Ran ZH （通讯作者） Incidence, Prevalence, and Temporal Trend of Microscopic Colitis: a Systematic Review and Meta-Analysis. Am J Gastroenterol Am J Gastroenterol 2015 2015;110(2):265-276
Nie F, Cao J, Tong J, Zhu M, Gao Y, Ran Z （通讯作者） Role of Raf-kinase inhibitor protein in colorectal cancer and its regulation by hydroxycamptothecine J Biomed Sci 2015 16;22:56
Wang TR, Peng JC, Qiao YQ, Zhu MM, Zhao D, Shen J, Ran ZH （通讯作者） Helicobacter pylori regulates TLR4 and TLR9 during gastric carcinogenesis Int J Clin Exp Pathol 2014 2014 Sep 15;7(10):6950-5
Xu J, Lin H, Feng X, Tang M, Shen J, Ran Z （通讯作者） Different therapeutic approaches on quality of life in patients with inflammatory bowel disease BMC Gastroenterol 2014 2014 Nov 25;14(1):199
Huang ML, Xu XT, Shen J, Qiao YQ, Dai ZH, Ran ZH （通讯作者） Prevalence and factors related to hepatitis B and C infection in inflammatory bowel disease patients in China: A retrospective study J Crohns Colitis 2014 2014 Apr;8(4):282-7
Cao Y, Shen J, Ran ZH （通讯作者） Association between Faecalibacterium prausnitzii Reduction and Inflammatory Bowel Disease: A Meta-Analysis and Systematic Review of the Literature Gastroenterol Res Pract 2014 2014;2014:872725.
Peng JC, Shen J, Ran ZH （通讯作者） Novel Agents in the Future: Therapy beyond anti-TNFs in Inflammatory Bowel Diseases J Dig Dis 2014 2014 Nov;15(11):585-90
Qiao YQ, Shen J, Gu Y, Tong JL, Xu XT, Huang ML, Ran ZH （通讯作者） Gene expression of TRAF-1 and TRAF-2 in inflammatory bowel disease J Dig Dis 2013 2013;14(5):244-50
Peng Jiang Chen, Shen Jun, Ran Zhi Hua （通讯作者） Transcribed ultraconserved region in human cancers. RNA biology 2013 2013 Dec 1;10(12):1771-7
Xu Q, Xu AT, Zhu MM, Tong JL, Xu XT, Ran ZH （通讯作者） Predictive and prognostic role of BRAF mutation in metastatic colorectal cancer patients treated with anti- epidermal growth factor receptor monoclonal antibodies: A meta-analysis J Dig Dis 2013 2013;14(8):409-16
Shen Jun, Qiao Yu Qi, Ran Zhi Hua （通讯作者）, Wang Tian Rong Up-regulation and Pre-activation of TRAF3 and TRAF5 in Inflammatory Bowel Disease Int J of Med Sci 2013 2013, 10:156-163
Yu Qi Qiao, Mei Lan Huang, An Tao Xu, Di Zhao, Zhi Hua Ran （通讯作者）, Jun Shen Lnc RNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn’s Disease J Biomed Sci. 2013 2013;20(1):87
Shen J, Qiao Y, Ran Z* （通讯作者）, Wang T, Xu J, Feng J Intestinal protein expression profile identifies inflammatory bowel disease and predicts relapse Int J Clin Exp Pathol 2013 2013 Apr 15;6(5):917-25
Shen Jun, Qiao Yu Qi, Ran Zhi Hua*, Wang Tian Rong （通讯作者） Different activation of TRAF4 and TRAF6 in inflammatory bowel disease. Mediators of Inflammation 2013 2013;2013:647936
Xu XT, Dai ZH, Xu Q, Qiao YQ, Gu Y, Nie F, Zhu MM, Tong JL, Ran ZH （通讯作者） Safety and efficacy of calcium and magnesium infusions in the chemoprevention of oxaliplatin induced sensory neuropathy in digestive tract cancers: A meta-analysis J Dig Dis 2013 2013 Jun;14(6):288-98
Tong JL, Feng Q, Shen J, Qiao YQ, Zheng Q, Gu Y, Chen XY, Li XB, Dai J, Hua J, Xu JR, Ran ZH （通讯作者） Computed tomography enterography versus balloon-assisted enteroscopy for evaluation of small bowel lesions in Crohn's disease. J Gastroenterol Hepatol 2013 2013 Jul;28(7):1180-6
Zhu MM, Tong JL, Xu Q, Nie F, Xu XT, Xiao SD, Ran ZH. （通讯作者） Increased JNK1 signaling pathway is responsible for ABCG2-mediated multidrug resistance in human colon cancer PLoS One 2012 7(8) : e41763.
Xu XT, Xu Q, Tong JL, Zhu MM, Nie F, Chen X, Xiao SD, Ran ZH. （通讯作者） MicroRNA Expression Profiling Identifies miR-328 regulates Cancer Stem Cell-Like SP Cells in Colorectal Cancer Br J Cancer 2012 Mar 27;106(7):1320-30
Tong JL, Huang ML, Xu XT, Qiao YQ, Ran ZH. （通讯作者） Once-daily versus multiple-daily mesalamine for patients with ulcerative colitis: A meta-analysis. J Dig Dis. 2012 Apr;13(4):200-7
Huang ML, Ran ZH （通讯作者）, Shen J, Li XB, Xu XT, Xiao SD Efficacy and safety of adalimumab in Crohn's disease: Meta-analysis of placebo-controlled trials J Dig Dis 2011 Jun;12(3):165-72
Jin Lu Tong, Chen Peng Zhang, Fang Nie, Xi Tao Xu, Ming Ming Zhu, Shu Dong Xiao, Zhi Hua Ran （通讯作者） MicroRNA 506 regulates expression of PPAR alpha in hydroxycamptothecin-resistant human colon cancer cells FEBS Letter 2011 585:3560-3568
Chen X, Ran ZH （通讯作者）, Tong JL, Nie F, Zhu MM, Xu XT, Xiao SD RNA interference (RNAi) of Ufd1 protein can sensitize a hydroxycamptothecin-resistant colon cancer cell line SW1116/HCTP to hydroxycamptothecin J Dig Dis 2011 12;110-116
Zhu MM、Xu XT、Nie F、Tong JL、Xiao SD、Ran ZH The efficacy and safety of selective leukocytapheresis in the treatment of ulcerative colitis: a meta-analysis Int J Colorectal Dis 2011 Aug;26(8):999-1007
Zhong M, Dong XW, Zheng Q, Tong JL, Ran ZH （通讯作者） MicroRNA 506 regulates expression of Factor V Leiden and thrombosis in patients with inflammatory bowel disease (IBD): A meta-analysis Thromb Res 2011 Nov;128(5):403-9
Xu XT, Xu Q, Tong JL, Zhu MM, Huang ML, Ran ZH （通讯作者）, Xiao SD Meta-analysis: Circulating adiponectin levels and risk of colorectal cancer and adenoma J Dig Dis 2011 Aug;12(4):234-44
Shen Jun, Qian Xiaoxian, Ran Zhihua （通讯作者）, Tong Jinlu, Qiao Yuqi and Huang Meilan Activated expression of CD27-CD70 co-stimulatory molecules in inflamed and non-inflamed tissues of intestinal mucosa in patients with inflammatory bowel disease Sci Res Essays 2011 Fub;6(4): 793–798
Xu Q, Yang CH, Liu Q, Jin XF, Xu XT, Tong JL, Xiao SD, Ran ZH （通讯作者） Chemopreventive effect of epigallocatechin-3-gallate (EGCG) and folic acid on the N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastrointestinal cancer in rat model J Dig Dis 2011 Jun;12(3):181-7
Zhu MM, Lu H （通讯作者）, Wang TR, Zheng Q, Ran ZH Concurrent amoebic and Klebsiella pneumoniae liver abscess in an immunocompetent patient: An unusual case report and review of the literature J Dig Dis 2010 11;249-253
Dong XW, Zheng Q, Zhu MM, Tong JL, Ran ZH （通讯作者） Thiopurine S - methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease World J Gastroentero 2010 Jul 7;16:3187-95
Zhu MM, Xu XT, Nie F, Tong JL, Xiao SD, Ran ZH （通讯作者） Comparison of immunochemical and guaiac-based fecal occult blood test in screening and surveillance for advanced colorectal neoplasms: a meta-analysis J Dig Dis 2010 11:148-60
Zhi Hua RAN （通讯作者）, Yao Zong YUAN, Zhao Shen LI, et al Sequential therapy vs. standard triple The efficacy of combizym in the treatment of Chinese patients with dyspepsia: a multicenter, randomized, placebo-controlled and cross-over study J Dig Dis 2009 10:41-48
Jun Shen, Zhi Hua Ran （通讯作者）, Yao Zhang, Qing Cai, Hong Min Yin, Xiao Tian Zhou, Shu Dong Xiao Meta-analysis: the effect and adverse events of Lactobacilli versus placebo Biomarkers of altered coagulation fibrinolysis as measures of disease activity in active inflammatory bowel disease: a gender-stratified cohort analysis Thrombosis research 2009 123:604-611
Fang NIE, Jun SHEN, Jin Lu TONG, Ming Ming ZHU, Xi Tao XU & Zhi Hua RAN Meta-analysis : the efficacy and the safety of monoclonal antibody targeted to epidermal growth factor receptor (EGFR) in the treatment of the patients with metastatic colorectal cancer (mCRC) J Dig Dis 2009 10：247–257
J.L.Tong, Z.H.Ran （通讯作者）, J.Shen, S.D.Xiao Sequential therapy vs. standard triple therapies for Helicobacter pylori infection: a meta-analysis J Clin Phar Ther 2009 34:41-53
J Shen、Z H Ran、H M Yin、X T Zhou and S D Xiao Meta-analysis: the effect and adverse events of Lactobacilli versus placebo in maintenance therapy for Crohn disease Internal Medicine Journal 2009 39: 103-109
Tong JL, Ran ZH （通讯作者）, Shen J, Fan GQ, Xiao SD Association between Fecal Bile Acids and Colorectal Cancer: A Meta-analysis of Observational Studies Yonsei Med J 2008 49:792-803
Zhi Hua Ran （通讯作者）, Chi chen, Shu dong Xiao Epigallocatechin-3-gallate ameliorates rats colitis induced by acetic acid. Biomedicine et Pharmacotherapy Biomedicine et Pharmacotherapy 2008 62: 189-196
Jun Shen, Zhi Hua Ran （通讯作者）, Jin Lu Tong, Xiang Chen, Shu Dong Xiao Endoscopic grading and scoring systems in inflammatory bowel disease are they the same？ Saudi Medical Journal 2008 10:41-48
Qin CAO, Zhi Hua RAN （通讯作者）, Shu Dong XIAO Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies J Dig Dis 2007 8:15-22
Zhi Hua RAN （通讯作者）, Qi XU, Jin Lu TONG, Shu Dong XIAO Apoptotic effect of Epigallocatechin-3-gallate on human gastric cancer cell line MKN45 via the activation of mitochondrial pathway World J Gastroenterol 2007 13:4255-4259
J. SHEN, Z. H. RAN （通讯作者）, J. L. TONG & S. D. XIAO Meta-analysis: the utility and safety of heparin in the treatment of active ulcerative colitis Aliment Pharmacol Ther 2007 26:653-663
Xiang Chen, Zhi Hua Ran （通讯作者）, Jin Lu Tong A meta-analysis of the yield of capsule endoscopy compared to double-balloon enteroscopy in patients with small bowel diseases World J Gastroenterol 2007 13:4372-4378
J. L. TONG, Z. H. RAN （通讯作者）, J. SHEN, C.X.ZHANG, S.D.XIAO Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy Aliment Pharmacol Ther 2007 25:155-168
Xiao Shudong and Ran Zhihua Recent advances in molecular biology of gastric carcinogenesis Chin Med J 2003 116(1): 3-4
Zhi Hua Ran （通讯作者）, Beatrice Rayet, Jean Rommelaere, and Steffen Faisst Parvovrius H-1 induced cell death: influence of intracellular NAD consumption on the regulation of necrosis and apoptosis Virus Research 1999 65(1999)161-174