导师姓名： 李圣贤 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属仁济医院 三级学科/
专业领域： 内分泌与代谢病
导师类型： 硕士生导师 专业学位导师：
联系方式： rj_shengxianli@163.com
邮编： 200127 邮箱地址： rj_shengxianli@163.com

研究方向 (点击浏览详细信息)
DHEAS改善胰岛功能的分子机制
代谢紊乱以生殖异常

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** PCOS卵泡液脂质谱改变对卵巢功能和辅助生殖结局的影响及机制的研究 国家自然科学基金面上项目 2017-01~2020-12 57万元 子课题负责人
** 硫酸脱氢表雄酮在胰岛β细胞中的作用及其机制 的研究 国家自然科学基金面上项目 2015-01~2018-12 73万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Huang R, Xue X, Li S （共同第一作者）, Wang Y, Sun Y, Liu W, Yin H, Tao T. Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats. J Cell Mol Med. 2018 22(7):3388-3396.
Ma J, Yue J, Huang R, Liao Y, Li S （通讯作者）, Liu W. Reversion of aging-related DHEAS decline in mouse plasma alleviates aging-related glucose tolerance impairment by potentiation of glucose-stimulated insulin secretion of acute phase. Biochem Biophys Res Commun. 2018 500(3):671-675.
Deng Y, Zhang Y, Li S （共同第一作者）, Zhou W, Ye L, Wang L, Tao T, Gu J, Yang Z, Zhao D, Gu W, Hong J, Ning G, Liu W, Wang W. Steroid hormone profiling in obese and nonobese women with polycystic ovary syndrome. Sci Rep. 2017 7(1):14156.
Li S, Chu Q, Ma J, Sun Y, Tao T, Huang R, Liao Y, Yue J, Zheng J, Wang L, Xue X, Zhu M, Kang X, Yin H, Liu W. Discovery of novel lipid profiles in PCOS: Do insulin and androgen oppositely regulate bioactive lipid production? J Clin Endocrinol Metab. 2017 102(3):810-821.
Feng R, Qian C, Liu Q, Jin Y, Liu L, Li S, Liao Y, Zhou H, Liu W, Rayner CK, Ma J. Expression of sweet taste receptor and gut hormone secretion in modelled type 2 diabetes. Gen Comp Endocrinol. 2017 252:142-149.
Liao Y, Huang R, Sun Y, Yue J, Zheng J, Wang L, Tao T, Ma J, Li S （通讯作者）, Liu W. An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients. Reprod Biol Endocrinol. 2017 15(1):9.
Li S, Liao Y, Wang L, Huang R, Yue J, Xu H, Zhou H, Lou Z, Hu Y, Liu W. Dysregulation of Hypothalamo-Pituitary-Adrenocortical Axis in Overweight Female Diabetic Subjects is Associated with Downregulation of Corticosteroid Receptors and 11β-HSD1 in the Brain. Horm Metab Res. 2016 48(3):178-184.
Fan H, Dong W, Li Q, Zou X, Zhang Y, Wang J, Li S, Liu W, Dong Y, Sun H, Hou Z. Ajuba Preferentially Binds LXRα/RXRγ Heterodimer to Enhance LXR Target Gene Expression in Liver Cells. Mol Endocrinol. 2015 29(11):1608-1618.
Huang R, Zheng J, Li S, Tao T, Ma J, Liu W. Characteristics and contributions of hyperandrogenism to insulin resistance and other metabolic profiles in polycystic ovary syndrome. Acta Obstet Gynecol Scand. 2015 94(5):494-500.
Huang R, Yue J, Sun Y, Zheng J, Tao T, Li S （通讯作者）, Liu W. Increased serum chemerin concentrations in patients with polycystic ovary syndrome: Relationship between insulin resistance and ovarian volume. Clin Chim Acta. 2015 450:366-369
Cao HM, Ye XP, Ma JH, Jiang H, Li SX （共同第一作者）, Li RY, Li XS, Guo CC, Wang ZQ, Zhan M, Zuo CL, Pan CM, Zhao SX, Zheng CX, Song HD. Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling. EBioMedicine. 2015 2(11):1718-1724.
Lin T, Li S （共同第一作者）, Xu H, Zhou H, Feng R, Liu W, Sun Y, Ma J. Gastrointestinal hormone secretion in women with polycystic ovary syndrome: an observational study. Hum Reprod. 2015 30(11):2639-44.
Dong Y, Gao G, Fan H, Li S, Li X, Liu W. Activation of the Liver X Receptor by Agonist TO901317 Improves Hepatic Insulin Resistance via Suppressing Reactive Oxygen Species and JNK Pathway. PLoS One. 2015 24;10(4):e**.
Huang R, Zheng J, Li S, Tao T, Liu W. Subclinical hypothyroidism in patients with polycystic ovary syndrome: distribution and its association with lipid profiles. Eur J Obstet Gynecol Reprod Biol. 2014 177:52-56.
Li S, Tao T, Wang L, Mao X, Zheng J, Zhao A, Liu W. The expression of 11β-HSDs, GR, and H6PDH in subcutaneous adipose tissue from polycystic ovary syndrome subjects. Horm Metab Res. 2013 45(11):802-807.
Yue J, Wang L, Huang R, Li S, Ma J, Teng X, Liu W. Dehydroepiandrosterone-sulfate (DHEAS) promotes MIN6 cells insulin secretion via inhibition of AMP-activated protein kinase. Biochem Biophys Res Commun. 2013 440(4):756-761.
Tao T, Li S （共同第一作者）, Zhao A, Zhang Y, Liu W Expression of the CD11c gene in subcutaneous adipose tissue is associated with cytokine level and insulin resistance in women with polycystic ovary syndrome. Eur J Endocrinol. 2012 167(5):705-713.
Wang L, Li S （共同第一作者）, Zhao A, Tao T, Mao X, Zhang P, Liu W. The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients. J Steroid Biochem Mol Biol. 2012 132(1-2):120-126.
Tao T, Li S （共同第一作者）, Zhao A, Mao X, Liu W. Early impaired β-cell function in chinese women with polycystic ovary syndrome. Int J Clin Exp Pathol. 2012 5(8):777-86.
Li SX, Liu W, Wang LH, et al. Effects of menopause on hepatic 11beta-HSD1 activity and adrenal sensitivity to adrenocorticotropin in healthy non-obese women. Gynecological Endocrinology 2011 27(10):794-799.
Hu Y, Liu W, Chen Y, Zhang M, Wang L, Zhou H, Wu P, Teng X, Dong Y, Zhou Jw, Xu H, Zheng J, Li S, Tao T, Hu Y, Jia Y. Combined use of fasting plasma glucose and glycated hemoglobin A1c in the screening of diabetes and impaired glucose tolerance. Acta Diabetol. 2010 47(3):231-236.
Li RY, Li XS, Shao L, Wu ZY, Du WH, Li SX, Zhao SX, Chen KM, Chen MD, Song HD. Influence of visceral adiposity on ghrelin secretion and expression in rats during fasting. J Mol Endocrinol. 2009 42(1):67-74.
Zheng CX, Zhao SX, Wang P, Yu HM, Wang CF, Han B, Su B, Xiang Y, Li XS, Li SX, Ma QY, Zhang RX, Wan HY, Song HD. Different expression of mimecan as a marker for differential diagnosis between NSCLC and SCLC. Oncol Rep. 2009 22(5):1057-1061.
Yuan G, Chen X, Ma Q, Qiao J, Li R, Li X, Li S, Tang J, Zhou L, Song H, Chen M. C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes. J Endocrinol. 2007 194(2):275-81.