导师姓名： 戈之铮 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属仁济医院 三级学科/
专业领域： 消化系病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： zhizhengge@aliyun.com
邮编： 200127 邮箱地址： zhizhengge@yahoo.com.cn

研究方向 (点击浏览详细信息)
胃肠道肿瘤和小肠疾病的诊治及机制研究

社会任职
中国医师协会内镜医师分会常务
上海消化内镜学会前任主任委员
中华医学会消化内镜学会常委
全国胶囊内镜协作组组长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
ZH2018ZDA06 缺氧调控的EGFL6用于小肠血管畸形的基因诊断治疗和预后预测 上海交通大学“转化医学交叉研究基金”项目 2019-01~2021-12 100万元 课题负责人
** 小肠血管畸形治疗新靶点——SNORA31抑制核仁素细胞膜表达的机制研究 国家自然科学基金 2017-01~2020-01 58万元 课题负责人
16CR3113B 沙利度胺治疗难治性消化道出血的随机安慰剂对照研究 申康－三年行动计划－专科疾病临床五新转化项目 2016-12~2019-06 30万元 课题负责人
2013YQ** 微型胶囊式影像和生物动力分析仪在上消化道检查中的循证对比方法研究 国家重大科技仪器设备开发专项 2016-05~2018-12 50万元 子课题负责人
DLY201501 胃肠道血管畸形所致消化道出血规范化治疗策略的研究及推广 高峰高原重点学科建设计划 2015-12~2020-12 100万元 课题负责人
W2015JZC10 结直肠癌诊断及微创手术治疗规范研究 国家卫生计生委项目 2015-06~2017-06 30万元 课题负责人
** HIF-1α 及VEGF 在血管畸形发生发展的相互作用机制与沙利度胺的相关作用研究 国家自然科学基金面上项目 2013-01~2016-12 65万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhang QW, Sun LC, Tang CT, Liang Q, Zhou YY, Chen HM, Gao YJ, Ge ZZ （通讯作者） Inverse Association of Age With Risk of Lymph Node Metastasis in Superficial Colorectal Cancer: A Large Population-Based Study Oncologist 2020 Online ahead of print
Tang CT, Zhang QW, Wu S, Tang MY, Liang Q, Lin XL, Gao YJ, Ge ZZ. （通讯作者） Thalidomide Targets EGFL6 to Inhibit EGFL6/PAX6 Axis-Driven Angiogenesis in Small Bowel Vascular Malformation Cell Mol Life Sci 2020 Online ahead of print.
Wu S, Zhong L, Zheng P, Wang YG, Ding WQ, Yu Q, Hui PP, Chen HM, Gao YJ, Ge ZZ （通讯作者） Low-dose and same day use of polyethylene glycol improves image of video capsule endoscopy: A multi-center randomized clinical trial. J Gastroenterol Hepatol. 2020 35(4):634-640
Liang Q, Tang C, Tang M, Zhang Q, Gao Y, Ge Z. （通讯作者） TRIM47 Is Up-Regulated in Colorectal Cancer, Promoting Ubiquitination and Degradation of SMAD4 J Exp Clin Cancer Res 2019 38(1):159.
Tang CT, Gao YJ, Ge ZZ. （通讯作者） NOX4, a New Genetic Target for Anti-Cancer Therapy in Digestive System Cancer J Dig Dis 2018 19(10):578-585
Tang CT, Liang Q, Yang L, Lin XL, Wu S, Chen Y, Zhang XT, Gao YJ, Ge ZZ. （通讯作者） RAB31 Targeted by MiR-30c-2-3p Regulates the GLI1 Signaling Pathway, Affecting Gastric Cancer Cell Proliferation and Apoptosis Front Oncol 2018 8:554
Tang CT, Lin XL, Wu S, Liang Q, Yang L, Gao YJ, Ge ZZ. （通讯作者） NOX4-driven ROS Formation Regulates Proliferation and Apoptosis of Gastric Cancer Cells Through the GLI1 Pathway Cell Signal 2018 46:52-63
Lin XL, Yang L, Fu SW, Lin WF, Gao YJ, Chen HY, Ge ZZ. （通讯作者） Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer. Oncotarget.. 2017 8(20):33586-33600
Wu S, Gao YJ, Ge ZZ. （通讯作者） Optimal use of polyethylene glycol for preparation of small bowel video capsule endoscopy: a network meta-analysis. Curr Med Res Opin. 2017 33(6):1149-1154.
Yang L, Lin XL, Liang W, Fu SW, Lin WF, Tian XQ, Gao YJ, Chen HY, Dai J, Ge ZZ. （通讯作者） High expression of GPR116 indicates poor survival outcome and promotes tumor progression in colorectal carcinoma. Oncotarget. 2017 Vol. 8, (No. 29), pp: 47943-47956
Chen H, Fu S, Feng N, Chen H, Gao Y, Zhao Y, Xue H, Zhang Y, Li X, Dai J, Fang J, Ge Z. （通讯作者） Bleeding?recurrence?in?patients?with?gastrointestinal?vascular malformation?afterthalidomide. Medicine (Baltimore). 2016 95(33):e4606
Feng N,?Chen H,?Fu S,?Bian Z,?Lin X,?Yang L,?Gao Y,?Fang J,?Ge Z. （通讯作者） HIF-1α and HIF-2α?induced?angiogenesis?in?gastrointestinal?vascular?malformation?and?reversed?bythalidomide. Sci Rep. 2016 1;6:27280.
Tan W, Ge ZZ （通讯作者）, Gao YJ, Li XB, Dai J, Fu SW, Zhang Y, Xue HB, Zhao YJ. Long-term outcome in patients with obscure gastrointestinal bleeding after capsule endoscopy. J Dig Dis. 2015 J Dig Dis.?2015 Mar;16(3):125-34. doi: 10.1111/1751-2980.12222.
Gong S, Xue HB,?Ge ZZ （通讯作者）, Dai J, Li XB, Zhao YJ, Zhang Y, Gao YJ, Song Y. Value of Magnifying Endoscopy With Narrow-Band Imaging and Confocal Laser Endomicroscopy in Detecting Gastric Cancerous Lesions. Medicine (Baltimore). 2015 2015 Nov;94(44):e1930. doi: 10.1097/MD.1930.
Feng Q, Tan HH,?Ge ZZ （通讯作者）, Gao YJ, Chen HM, Xiao SD. Thalidomide-induced angiopoietin 2, Notch 1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells. J Dig Dis. 2014 15(2):85-95
Feng N, Dai J, Lu H, Li XB, Gao YJ, Ge ZZ. （通讯作者） Hyperamylasemia is associated with increased intestinal permeability in patients undergoing diagnostic oral double-balloon enteroscopy. World J Gastroenterol. 2014 20(2):539-45
Xuan Li, Yun-Jia Zhao,Zhi-Zheng Ge （通讯作者）,et al. Carbon dioxide insufflation improves the intubation depth and total enteroscopy rate in single-balloon enteroscopy: a randomised, controlled, double-blind trial Gut 2014 63(10):1560-5
Li Y1,?Fu S,?Chen H,?Feng Q,?Gao Y,?Xue H,?Ge Z （通讯作者）,et al. Inhibition of Endothelial Slit2/Robo1 Signaling by Thalidomide Restrains Angiogenesis by Blocking the PI3K/Akt Pathway. Dig Dis Sci. 2014 59(12):2958-2966.
Xue H1, Gong S, Shen Y, Tan H, Fujishiro M2, Dai J, Zhao Y, Ge Z. （通讯作者） effect of a training programme on the diagnosis of oesophageal lesions by narrow band imaging magnification among endoscopists of varying experience. Dig Liver Dis. 2014 46(7):609-15
Dai J, Shen YF, Sano Y,GZZ （通讯作者）,et al. Evaluation of narrow-band imaging in the diagnosis of colorectal lesions: is a learning curve involved? Dig Endosc. 2013 25(2):180-8
Yang L, Ge ZZ （通讯作者）, Gao YJ,et al. Assessment of capsule endoscopy scoring index, clinical disease activity, and C-reactive protein in small bowel Crohn's disease. J Gastroenterol Hepatol. 2013 28(5):829-33
Ye CA, Gao YJ, Ge ZZ （通讯作者）,et al. Pillam COLON capsule endoscopy versusconventional colonoscopy for the detection of the severity and extent of ulcerative colitis J Dig Dis. 2013 14(3):117-24
Tan H,Chen H,Ge ZZ （通讯作者）,et al. Role of vascular endothelial growth factor in angiodysplasia: An interventional study with thalidomide. J Gastroenterol Hepatol. 2012 27(6):1094-101
Yang H,Ge ZZ （通讯作者）,et al. Effectiveness of the immunofecal occult blood test for colorectal cancer screening in a large population. Dig Dis Sci. 2011 56(1):203-7
Tan H,Chen H,Ge ZZ （通讯作者）,et al. The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: a pilot in vivo study. J Dig Dis. 2011 12(5):349-56
Xue HB,Ge ZZ （通讯作者）,et al. A pilot study of endoscopic spray cryotherapy by pressurized carbon dioxide gas for Barrett's esophagus. Endoscopy. 2011 43(5):379-85
Ge ZZ （通讯作者）,Chen HM,et al. Efficacy of thalidomide for refractory gastrointestinal bleeding from vascular malformation. Gastroenterology. 2011 141(5):1629-37.e1-4.
Li X,Dai J,Xue H,Gao Y,Ge ZZ （通讯作者）,et al. A prospective study on evaluating the diagnostic yield of video capsule endoscopy followed by directed double-balloon enteroscopy in patients with obscure gastrointestinal bleeding. Dig Dis Sci. 2010 55(6):1704-10.
Gao YJ,Ge ZZ （通讯作者）,et al. Endoscopic capsule placement improves the completion rate of small-bowel capsule endoscopy Gastrointest Endosc. 2010 72(1):103-8.
Li XB,Ge ZZ （通讯作者）,et al. A novel modality for the estimation of the enteroscope insertion depth during double-balloon Gastrointest Endosc. 2010 72(5):999-1005
Dai J,Ge ZZ （通讯作者）,et al. Transparent cap improves patients' tolerance of colonoscopy and shortens examination time by inexperienced endoscopists. J Dig Dis. 2010 11(6):364-8
X.Li,J.Dai,Y.Zhao,Z.Ge （通讯作者）,et al. Predictive role of capsule endoscopy on the insertion route of double-balloon enteroscopy. Endoscopy 2009 41:762-766.
Wei W, Ge ZZ （通讯作者）, et al. Purgative Bowel Cleansing Combined With Simethicone Improves Capsule Endoscopy Imaging. Am J Gastroenterol 2008 103:77-82.
Dai J, Ge ZZ （通讯作者）, et al. Relationship between fecal lactoferrin and inflammatory bowel disease. Scand J Gastroenterol. 2007 21:1-5
Wei W, Ge ZZ （通讯作者）, et al. Effect of mosapride on gastrointestinal transit time and diagnostic yield of capsule endoscopy. J Gastroenterol Hepatol. 2007 22:1605-8.
X. Li, Z. Ge （通讯作者）, et al. The role of capsule endoscopy combined with double-balloon enteroscopy in diagnosis of small bowel diseases. Chin Med J (Engl). 2007 120:30-5
Ge ZZ （通讯作者）, Chen XY, et al. Best candidates for capsule endoscopy for obscure gastrointestinal bleeding. J Gastroenterol Hepatol. 2007 22:2076-2080.
Ge ZZ （通讯作者）, Chen XY, et al. Clinical application of wireless capsule endoscopy in pediatric patients for suspected small bowel diseases. Eur J Pediatr. 2007 166:825-9.
Ge ZZ （通讯作者）, Chen XY, et al. The role of simeticone in small-bowel preparation for capsule endoscopy. Endoscopy 2006 38:836-40.
Ge ZZ （通讯作者）, Hu YB, et al. Capsule endoscopy in diagnosis of small bowel Crohn's disease. World J Gastroenterol. 2004 10:1349-52.
Ge ZZ （通讯作者）, Hu YB, et al. Capsule endoscopy and push enteroscopy in the diagnosis of obscure gastrointestinal bleeding. Chin Med J (Engl). 2004 117:1045-9.
Ge ZZ （通讯作者）, Zhang DZ, et al. Does eradication of Helicobacter pylori alone heal duodenal ulcers? Aliment Pharmacol Ther. 2000 14:53-8.