导师姓名： 陆红 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属仁济医院 三级学科/
专业领域： 消化系病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： hlu@sjtu.edu.cn
邮编： 200127 邮箱地址： honglu02@yahoo.com

研究方向 (点击浏览详细信息)
幽门螺杆菌相关疾病（胃癌）的基础及临床研究

社会任职
中华医学会消化病学分会幽门螺杆菌学组副组长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 幽门螺杆菌spoT基因调控氧应激严谨应答在甲硝唑耐药发生中的作用机 制研究 国家自然科学基金面上项目 2020-01~2023-12 57万元 课题负责人
** 甲硝唑耐药和逆转过程中幽门螺杆菌全基因组转录水平的调控作用 国家自然基金委,面上项目 2014-01~2017-12 65万元 主要责任人
** 甲硝唑耐药和逆转过程中miRNA-218介导的NF-κB活化在十二指肠球部溃疡发生中的作用和机制 国家自然基金委,面上项目 2012-01~2015-12 65万元 主要责任人
** 幽门螺杆菌粘附素AlpAB及其与胃粘膜上皮受体的相互作用在粘附和致病中的作用研究 国家自然基金委,面上项目 2008-01~2010-12 30万元 课题负责人
** 幽门螺杆菌dupA基因在十二指肠溃疡发生中的作用及其机理的研究 国家自然基金委,面上项目 2007-01~2009-12 27万元 课题负责人
幽门螺杆菌dupA基因在十二指肠溃疡发生中的作用及其机理的研究 国家教育部,博士点基金 2007-01~2009-12 6万元
06PJ14066 幽门螺旋杆菌dupA基因在十二指肠溃疡发生中的作用及其机制的研究 上海市科委,浦江人才 2006-09~2008-09 20万元 课题负责人
05HX21021 幽门螺杆菌十二指肠溃疡促发基因dupA作用机理的研究 横向课题 2006-01~2008-12 5万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Laisheng Luo, Yu Huang, Xiao Liang, Yingjie Ji, Lou Yu and Hong Lu Susceptibility-guided therapy for Helicobacter pylori-infected penicillin-allergic patients: A prospective clinical trial of firstline and rescue therapies Helicobacter 2020 e12699
Laisheng Luo, Yingjie Ji, Lou Yu, Yu Huang, Xiao Liang, David Y. Graham and Hong Lu 14 Day High Dose Amoxicillin and Metronidazole Containing Triple Therapy With or Without Bismuth as First-Line Helicobacter pylori Treatment Digestive Diseases and Sciences 2020 Online ahead of print
Qi Chen, Xiaohua Long, Yingjie Ji, Xiao Liang, Dongping Li,Hong Gao, Beili Xu, Ming Liu, Ying Chen, Yunwei Sun, Yan Zhao, Gang Xu, Yanyan Song, Lou Yu, Wei Zhang, Wenzhong Liu, David Y. Graham and Hong Lu Randomised controlled trial: susceptibility‐guided therapy versus empiric bismuth quadruple therapy for first‐line Helicobacter pylori treatment Alimentary Pharmacology and Therapeutics 2019 49(11):1385-1394
Lou Yu, Laisheng Luo, Xiaohua Long, Xiao Liang, Yingjie Ji, David Y. Graham and Hong Lu High‐dose PPI‐amoxicillin dual therapy with or without bismuth for first‐line Helicobacter pylori therapy: A randomized trial Helicobacter 2019 e12596
Lou Yu, Laisheng Luo, Xiaohua Long, Xiao Liang, Yingjie Ji, Qi Chen, Yanyan Song, Xiaobo Li, David Y. Graham and Hong Lu Susceptibility-guided therapy for Helicobacter pylori infection treatment failures Therapeutic Advances in Gastroenterology 2019 12: 1–10
Xiaohua Long,Qi Chen,Lou Yu,Xiao Liang,Wenzhong Liu and Hong Lu Bismuth improves efficacy of proton-pump inhibitor clarithromycin, metronidazole triple Helicobacter pylori therapy despite a high prevalence of antimicrobial resistance Helicobacter 2018 23:e12485
Qi Chen, Wei Zhang, Qingyan Fu, Xiao Liang, Wenzhong Liu, Shudong Xiao, and Hong Lu （通讯作者） Rescue Therapy for Helicobacter pylori Eradication: A Randomized Non-Inferiority Trial of Amoxicillin or Tetracycline in Bismuth Quadruple Therapy The American Journal of GASTROENTEROLOGY 2016 111:1736-42
Wei Zhang, Qi Chen, Xiao Liang, Wenzhong Liu, Shudong Xiao, David Y Graham, Hong Lu （通讯作者） Bismuth, lansoprazole, amoxicillin and metronidazole or clarithromycin as first-line Helicobacter pylori therapy Gut 2015 64(11):1715-20
Cao Zhijun, Chen Qi, Zhang Wei, Liang Xiao, Liao Jingxian, Liu Wenzhong, Xiao Shudong, Lu Hong （通讯作者） Fourteen-day optimized levofloxacin-based therapy versus classical quadruple therapy for Helicobacter pylori treatment failures: a randomized clinical trial Scandinavian Journal of Gastroenterology 2015 50(10):1185-90
Liao J, Zheng Q, Liang X, Zhang W, Sun Q, Liu W, Xiao S, Graham DY, Lu H （通讯作者） Effect of fluoroquinolone resistance on 14-day levofloxacin triple and triple plus bismuth quadruple therapy Helicobacter 2013 18(5):373-7
Liang X, Xu X, Zheng Q, Zhang W, Sun Q, Liu W, Xiao S, Lu H （通讯作者） Efficacy of Bismuth-Containing Quadruple Therapies for Clarithromycin-, Metronidazole-, and Fluoroquinolone-Resistant Helicobacter pylori Infections in a Prospective Study Clin Gastroenterol Hepatol. 2013 11(7):802-7
Lu H, Zhang W, Graham DY Bismuth-containing quadruple therapy for Helicobacter pylori: lessons from China Eur J Gastroenterol Hepatol 2013 25(10):1134-40
Sun Q, Liang X, Zheng Q, Liu W, Xiao S, Gu W, Lu H （通讯作者） High efficacy of 14-day triple therapy-based, bismuth-containing quadruple therapy for initial Helicobacter pylori eradication Helicobacter 2010 15(3):233-8
Gao C, Zhang Z, Liu W, Xiao S, Gu W, Lu H （通讯作者） Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer Cancer 2010 116(1):41-9
Sun QJ, Liang X, Zheng Q, Gu WQ, Liu WZ, Xiao SD, Lu H （通讯作者） Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai World J Gastroenterol 2009 16(40):5118-5121
Zhang Z, Li Z, Gao C, Chen P, Chen J, Liu W, Xiao S, Lu H （通讯作者） miR-21 plays a pivotal role in gastric cancer pathogenesis and progression Lab Invest 2008 88(12):1358-66
Zhang Z, Zheng Q, Chen X, Xiao S, Liu W, Lu H （通讯作者） The Helicobacter pylori duodenal ulcer promoting gene, dupA in China BMC Gastroenterol 2008 8(1):49
Lu H, Wu JY, Beswick EJ, Ohno T, Odenbreit S, Haas R, Reyes VE, Kita M, Graham DY, Yamaoka Y Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains J Biol Chem 2007 282(9):6242-54
Lu H, Wu JY, Kudo T, Ohno T, Graham DY, Yamaoka Y. Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori Mol Biol Cell 2005 16(10):4954-66
Lu H, Hsu PI, Graham DY, Yamaoka Y. Duodenal ulcer promoting gene of Helicobacter pylori Gastroenterology 2005 128(4):833-48
Lu H, Yamaoka Y, Graham DY Helicobacter pylori virulence factors: facts and fantasies Curr Opin Gastroenterol 2005 21(6):653-9
Lu H, Graham DY, Yamaoka Y The Helicobacter pylori restriction endonuclease-replacing gene, hrgA, and clinical outcome: comparison of East Asia and Western countries Dig Dis Sci 2004 49(9):1551-5