导师姓名： 吕良敬 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属仁济医院 三级学科/
专业领域： 风湿病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市山东中路145号仁济医院风湿科
邮编： 200001 邮箱地址： lu_liangjing@medmail.com.cn

研究方向 (点击浏览详细信息)
系统性红斑狼疮等重大自身免疫病防诊治精准化策略研究

社会任职
上海市医学会罕见病专委会委员
UpToDate中文版临床顾问
风湿科科副主任
Asian Lupus Nephritis Network (ALNN)委员
中华风湿病学会中青年委员，上海风湿病学会委员，全国医师定期考核风湿免疫专业专家/编辑委员会委员，上海市风湿病学会委员，上海风湿免疫学会委员
“诊断学理论与实践杂志”编委
中国医师协会风湿病分会常委
上海医师协会风湿病分会副会长
“中华风湿病学杂志”编委
上海医学杂志编委
上海风湿病研究所副所长
中华风湿免疫学会常委
上海市医疗事故鉴定委员会委员，上海市司法鉴定委员会委员，上海市劳动能力鉴定委员会医疗卫生专家、工伤康复医学专家
亚太地区风湿病联盟(APLAR)狼疮研究组(Asia Pacific SLE Workgroup)委员
中华医师协会风湿病分会委员
中国医师协会风湿病分会血管炎学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** Pleiotrophin通过调控Wnt/β-catenin通路在SLE相关性肺动脉高压导致的右 心室损伤中的作用 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
ZY(2018-2020)-FWTX-1009 系统性红斑狼疮(阴阳毒) 上海市中西医临床协作试点项目建设 2018-11~2020-11 60万元 子课题负责人
SHDC** 评价脐带间充质干细胞治疗膝骨关节炎的安全性、有效性的多中心、随机、双盲临床研究 上海市新兴前沿技术联合公关项目 2018-11~2021-11 150万元 课题负责人
ZY(2018-2020)-FWTX-1010 类风湿关节炎达标治疗策略研究 上海市中西医临床协作试点项目建设 2018-11~2020-11 44.7万元 子课题负责人
WF 基于系统生物学的重大自身免疫病防诊治精准化策略研究 “双一流”科研院培育配套建设项目 2018-06~2020-06 100万元 课题负责人
2017YFC** 基于系统生物学的重大自身免疫病防诊治精准化策略研究 国家重点研发计划"精准医学研究"重点专项(科技部) 2017-07~2020-07 1957万元 课题负责人
基于中国风湿性疾病人群离散事件仿真模型的建立及疾病临床管理与预后分析研究 上海交通大学医学院高原高峰项目 2016-01~2018-12 100万元 课题负责人
15DZ** 构建以微信公众号为载体的多媒体风湿免疫医患教育与交流平台 上海市科委2015年度“科技创新行动计划” 2016-01~2016-12 15万元 课题负责人
** MIF影响SLE激素抵抗的上游调控机制及其潜在靶点在鼠模型上的靶向研究 国家自然科学基金面上项目 2014-01~2017-12 70万元 课题负责人
** MIF在成人斯蒂尔病中异常增高的遗传学根源及其潜在致病通路的研究 国家自然基金委,面上项目 2011-01~2013-12 35万元 课题负责人
09ZR** 解析MIF在成人斯蒂尔病中的潜在致病通路 上海市自然科学基金 2009-08~2012-07 10万元 课题负责人
** MIF对糖皮质激素的拮抗效应在SLE激素抵抗发生机制中的意义 国家自然基金委,面上项目 2007-01~2009-12 24万元 课题负责人
** 高亲和力抗纤溶酶自身抗体的意义 国家自然科学基金 2004-01~2006-12 21万元 课题参与人
上海交通大学医学院“新****” 上海交通大学 ~ 15万元 主要责任人

学术论文 作者论文标题期刊名出版年卷期页码
Yuening Kang, Yuetian Yu, Liangjing Lu. （通讯作者） The role of pentraxin 3 in aspergillosis: reality and prospects. Mycobiology 2020 48(1):1-8
Jiayi Zheng#, Ruru Guo#, Qiong Fu, Jie Chen, Yuanjia Tang, Lingling Wu, Lin Leng, Richard Bucala, Yang Song* and Liangjing Lu* miR-152 Attenuates the Severity of Lupus Nephritis through the Downregulation of Macrophage Migration Inhibitory Factor (MIF)-Induced Expression of COL1A1 Front Immunol 2019 doi: 10.3389/fimmu.2019.00158
Yuetian Yu#, Chunyan Liu, Zhongheng Zhang, Hui Shen, Yujie LI, Liangjing Lu* （通讯作者）, Yuan Gao* Bronchoalveolar lavage fluid dilution in ICU patients: what we should know and what we should do Critical Care 2019 doi:10.1186/s13054-018-2300-x
Huijing Huan , Dandan Chen, Jun Pu, Ancai Yuan, Qiong Fu, Jia Li, Lin Leng, Richard Bucala, ShuangYe, LiangjingLu*. （通讯作者） The small molecule macrophage migration inhibitory factor antagonist MIF098, inhibits pulmonary hypertension associated with murine SLE. International Immunopharmacology 2019 76:105874.
Juan Wang, Guangliang Chen, Liangjing Lu* （通讯作者）, Hejian Zou*. Sirt1 inhibits gouty arthritis via activating PPARγ. Clin Rhum. 2019 38(11):3235-3242.
Si Wu, Xiaojun Tang, Liping Wu, Liang-jing Lu, Xuebing Feng. Association of anti-Ro52 autoantibodies with interstitial lung disease in connective tissue diseases. Ann Rheum Dis. 2019 216372
Ruru Guo, Ting Zhang, Xinyu Meng, Zhen Lin, Jinran Lin, Yu Gong, Xuesong Liu, Yuetian Yu, Gulin Zhao, Xianting Ding, Xiaoxiang Chen, and Liangjing Lu （通讯作者） Lymphocyte mass cytometry identifies a CD3-CD4+ cell subset with a potential role in psoriasis JCI insight 2019 4(6):e125306
Yuetian Yu, Jia Li, Suli Wang, Yuan Gao, Hui Shen, Liangjing Lu*. （通讯作者） Effect of Candida albicans bronchial colonization on hospitalacquired bacterial pneumonia in patients with systemic lupus erythematosus. Ann Transl Med 2019 7(22):673.
Yang Tu, Ruru Guo, Jia Li, Suli Wang, Lin Leng, Jun Deng, Richard Bucala, Liangjing Lu. （通讯作者） MiRNA Regulation of MIF in SLE and Attenuation of Murine Lupus Nephritis With miR-654. Frontiers in Immunology. 2019 10:2229
Liangjing Lu, Chengxiang Dai, Zhongwen Zhang, Hui Du, Suke Li, Ping Ye, Qiong Fu, Li Zhang, Xiaojing Wu, Yuru Dong, Yang Song, Dongbao Zhao, Yafei Pang and Chunde Bao. Treatment of knee osteoarthritis with intra-articular injection of autologous adipose-derived mesenchymal progenitor cells: a prospective, randomized, double-blind, active-controlled, phase IIb clinical trial. Stem Cell Res Ther 2019 10(1):143
Yuetian Yu#, Cheng Zhu#, Hui Shen, Chunyan Liu, Ruru Guo, Yuan Gao, Wenjuan Wu*, Liangjing Lu* （通讯作者） Galactomannan detection in bronchoalveolar lavage fluid corrected by urea dilution for the diagnosis of invasive pulmonary aspergillosis among nonneutropenic patients J Thorac Dis 2019 Doi:10.21037/jtd.2019.01.07
Yu Y#, Shen H, Zhu C, Guo R, Gao Y*, Lu L* （通讯作者） Infections Caused by Extended- Spectrum β-Lactamase Producing Escherichia Coli in Systemic Lupus Erythematosus Patients: Prevalence, Risk Factors, and Predictive Model Biomed Res Int 2018 2018:**
Xu C, Zhu C, Zhou M, Guo R, Lu L （通讯作者）, Yu Y Cutoff values of aspergillus galactomannan in exhaled breath condensate and bronchoalveolar lavage fluid need further adjustment CMI 2018 2018
Fu Q, Lu L, Xu J, et al. Leflunomide Versus Azathioprine for Maintenance Therapy of Lupus Nephritis: A Prospective, Multicenter, Randomized, Open-Label Clinical Trial ARTHRITIS & RHEUMATOLOGY 2018 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY, 2018, 70
Guo R#, Tu Y, Xie S, Liu X, Song Y, Wang S, Chen X, Lu L （通讯作者） A Role for Receptor-Interacting Protein Kinase-1 in Neutrophil Extracellular Trap Formation in Patients with Systemic Lupus Erythematosus: a Preliminary Study. Cell Physiol Biochem 2018 2018;45:2317–2328
Yu, Y., Hu, F., Zhu （通讯作者）, C., Chen, E., Lu, L., & Gao, Y Use of Next Generation Sequencing and Synergy Susceptibility Testing in Diagnosis and Treatment of Carbapenem-Resistant Klebsiella pneumoniae Blood Stream Infection Case reports in infectious diseases 2018 2018
Lu L... STAT3 hyperactivation associates with follicular helper T cell differentiation and disease activity in rheumatoid arthritis Frontiers in Immunology 2018 2018
Chunhui Xu#, Cheng Zhu#, Mi Zhou, Ruru Guo, Liangjing Lu* （通讯作者）, Yuetian* 'Aspergillus galactomannan detection in exhaled breath condensate compared to bronchoalveolar lavage fluid' by Husain, et al Clin Microbiol Infect 2018 24(9):1021-2
Song Y, Du H, Dai C, Zhang L, Li S, Hunter DJ, Lu L （通讯作者）, Bao C Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections Regen. Med 2018 2018 Feb 8
Guo R, Zhou Y, Lu L （通讯作者）, Cao L, Cao J Atopy in children with juvenile systemic lupus erythematosus is associated with severe disease PLoS one 2017 2017 May 17;doi:10.1371
Song Y, Chen SL, Shen N, Xue F, Ye P, Bao CD, Gu YY, Yu CZ, Lu LJ （通讯作者） Expression, localization, and clinical application of the RNA binding domain of U1-70kD in HEp-2 cells Ann Clin Lab Sci 2015 45(2):134-9
Wang SL, Hsieh E, Zhu LA, Wu B, Lu LJ （通讯作者） Comparative Assessment of Different Health Utility Measures in Systemic Lupus Erythematosus. Sci Rep 2015 21;5:13297.
Wu B, Song Y, Leng L, Bucala R, Lu LJ （通讯作者） Treatment of moderate rheumatoid arthritis with different strategies in a health resource-limited setting: a cost-effectiveness analysis in the era of biosimilars. Clin Exp Rheumatol 2015 33(1):20-6
4.Mok CC, Yap DY, Navarra SV, Liu ZH, Zhao MH, Lu L, Takeuchi T, Avihingsanon Y, Yu XQ, Lapid EA, Lugue-Lizardo LR, Sumethkul V, Shen N, Chen SL, Chan TM; Asian Lupus Nephritis Network (ALNN) Overview of Lupus Nephritis Management Guidelines and Perspective from Asia. Nephrology (Carlton) 2014 19(1):11-20
Navarra SV, Tang B, Lu L, Lin HY, Mok CC, Asavatanabodee P, Suwannalai P, Hussein H, Rahman MU Risk of tuberculosis with anti-tumor necrosis factor-a therapy: substantially higher number of patients at risk in Asia Int J Rheum Dis 2014 17(3):291-8
Wang SL, Wu B, Zhu LA, Leng L, Bucala R, Lu LJ. （通讯作者） Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus PLoS One 2014 9(6):98-1003
Song Y, Zhu LA, Wang SL, Leng L, Bucala R, Lu LJ. （通讯作者） Multi-dimensional health assessment questionnaire in china: reliability, validity and clinical value in patients with rheumatoid arthritis PLoS One 2014 9(5):97-952
Wang J, Guo G, Chen G, Wu B, Lu L, Bao L Meta-analysis of the association of dermatomyositis and polymyositis with cancer Br J Dermatol 2013 169(4):838-47
Wang FF, Huang X, Shen N, Leng L, Bucala R, Chen SL, Lu LJ （通讯作者） A genetic role for macrophage migration inhibitory factor (MIF) in Adult-onset stills disease Arthritis Res Ther 2013 15(3):65-65
Wang SL, Wu B, Leng L, Bucala R, Lu LJ （通讯作者） Validity of LupusQoL-China for the assessment of health related quality of life in Chinese patients with systemic lupus erythematosus PLoS ONE 2013 8(5):63-79
Wang SL, Wang FF, Chen SL, Shen N, Xue F, Ye P, Bao CD, Gu YY, Yu CZ, Wilson A, Wallace DJ, Weisman MH （通讯作者）, Lu LJ. Expression, localization and clinical application of exogenous Smith proteins D1 in gene transfected HEp-2 cells. Int J Rheum Dis 2013 16(3):303-9
9.Mok CC, Yap DY, Navarra SV, Liu ZH, Zhao MH, Lu L, Takeuchi T, Avihingsanon Y, Yu XQ, Lapid EA, Lugue-Lizardo LR, Sumethkul V, Shen N, Chen SL, Chan TM; Asian Lupus Nephritis Network (ALNN) Overview of Lupus Nephritis Management Guidelines and Perspective from Asia Int J Rheum Dis 2013 16(6):625-36
Wang FF, Zhu LA, Zou YQ, Zheng H, Wilson A, Yang CD, Shen N, Wallace DJ, Weisman MH, Chen SL, Lu LJ （通讯作者） Validity of LupusQoL-China for the assessment of health related quality of life in Chinese patients with systemic lupus erythematosus Arthritis Res Ther 2012 14(3):103
Du F, Lu LJ, Bao CD T-614 alters the production of matrix metalloproteinases (MMP-1 and MMP-3) and inhibits the migratory expansion of rheumatoid synovial fibroblasts in vitro International Immunopharmacology 2012 3:2-8
Wu B, Wilson A, Wang F-f, Wang S-l, Wallace DJ, Weisman MH, Lu L-J （通讯作者） Cost Effectiveness of Different Treatment Strategies in the Treatment of Patients with Moderate to Severe Rheumatoid Arthritis in China PLoS ONE 2012 7(10):37-47
Lu LJ, Wallace DJ, Weisman M, et al. Male SLE: A Review of Sex Disparities in this Disease. LUPUS 2010 9:119-129
Lu LJ, Wallace DJ, Navarra SV, et al. Lupus Registries: Evolution and Challenges. Semin Arthritis Rheum 2010 39(4):224-245
Lu LJ, Bao CD, Dai Min, et al. Multicenter, randomized, double-blind, controlled trial of treatment of active rheumatoid arthritis with T-614 compared with methotrexate. Arthritis Rheum 2009 61(7):979-87
Zhang CY, Lu LJ （共同第一作者）, Li FH, et al. Evaluation of risk factors that contribute to high prevalence of premature atherosclerosis in Chinese premenopausal systemic lupus erythematosus patients. J Clin Rheumatol. 2009 15(3):111-6.
Zou YQ, Lu LJ （通讯作者）, Li SJ, et al. The levels ofmacrophage migration inhibitory factor as an indicator of disease activity and severity in adult-onset Still's disease. Clin Biochem. 2008 41(7-8):519-24.
Du F, Lu LJ, Fu Q, et al. T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis. Arthritis Res Ther. 2008 10(6):R136
Lu LJ, Teng JL, Bao CD, et al. Safety and efficacy of T-614 in the treatment of patients with active rheumatoid arthritis: a double blind, randomized, placebo-controlled and multicenter trial. Chin Med J 2008 121(7):615-9.
Lu LJ （通讯作者）,Zou YQ,Gou GM,et al. Outcome of lupus renal disease in the past two decades: a report from China. APLAR Journal of Rheumatology 2006 9;347-352
Lu Liangjing （通讯作者）, Chen Shunle, Gu Yueying, et al. Transfection,overexpression and clinical application of the human60-kDa Ro/SSA autoantigens in HEp-2 cells. Chin Med J 2003 116（3）；281-283.