导师姓名： 武志祥 专业代码： 100202
性别： 男 专业名称： 儿科学
培养单位： 附属新华医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： wuzhixiang@xinhuamed.com.cn
邮编： 邮箱地址： zhixiangwu@yahoo.com

研究方向 (点击浏览详细信息)
儿童实体肿瘤的发病机制、耐药机制、分子诊断及个体化治疗

社会任职
中华医学会抗癌协会小儿抗癌分会青年委员
上海医学会小儿外科分会青年委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 基于TH-MYCN小鼠的MYCN扩增型神经母细胞瘤新致病机制研究 国家自然基金委 2019-01~2022-12 57万元 课题负责人
XH2698 上海市“医苑新星”青年医学人才培养资助计划 上海市卫健委 2019-01~2021-12 20万元 课题负责人
16QA** 儿童神经母细胞瘤自然转归机制研究 上海市科委 2016-04~2019-03 40万元 课题负责人
** ALK异常型神经母细胞瘤原发性耐药机制的磷酸化蛋白组学研究 国家自然基金委 2015-01~2017-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chen H, Lin H, Xu M, Xu G, Fang X, He L, Chen Z, Wu Z （通讯作者）, Geng H Quantitative Urinary Proteome Reveals Potential Biomarkers for Ureteropelvic Junction Obstruction Proteomics Clin Appl 2019 13(4):e**
Cheng C, Wu Y, Pan W, Wang J, Wu Z, Lv F. Follow-Up Report of Laparoscopic Fundoplication in Different Types of Esophageal Hiatal Hernia in Children J Laparoendosc Adv Surg Tech A 2019 29(10):1320-1324
Y Cai, F Lv, N Kaldybayeva, A Zhamilya, Z Wu （通讯作者）, Y Wu 15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo Frontiers in pharmacology 2018 9,25
K Chen, Y Cai, M Zhang, Z Wu （通讯作者）, Y Wu Both serum and tissue Galectin‐1 levels are associated with adverse clinical features in neuroblastoma Pediatric Blood & Cancer 2018 e27229
金惠明,武志祥 （通讯作者） 先天性哑铃形神经母细胞瘤3例疗效分析 临床儿科杂志 2018 36(12)
Gu Y, Lv F, Xue M, Chen K, Cheng C, Ding X, Jin M, Xu G, Zhang Y, Wu Z （通讯作者）, Zheng L, Wu Y The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation J Exp Clin Cancer Res 2018 Oct 25;37(1):258
Chen H, Lin H, Xu M, Xu G, Fang X, He L, Chen Z, Wu Z （通讯作者）, Geng H Quantitative Urinary Proteome Reveals Potential Biomarkers for Ureteropelvic Junction Obstruction Proteomics Clin Appl 2018 Nov 24:e**
Nagel MK, Kalinowska K, Vogel K, Reynolds GD, Wu Z, Anzenberger F, Ichikawa M, Tsutsumi C, Sato MH, Kuster B, Bednarek SY, Isono E. Arabidopsis SH3P2 is an ubiquitin-binding protein that functions together with ESCRT-I and the deubiquitylating enzyme AMSH3 Proc Natl Acad Sci U S A 2017 2017 Aug 7. pii:
B Liu, H Lu, D Li, X Xiong, L Gao, Z Wu, Y Lu （通讯作者） Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice Diabetes 2017 db161104
Gu S, Chen K, Yin M, Wu Z （通讯作者）, Wu Y Proteomic profiling of isogenic primary and metastatic medulloblastoma cell lines reveals differential expression of key metastatic factors. J Proteomics 2017 2017 May 8;160:55-63
Y Wang, K Chen, Y Cai, Y Cai, X Yuan, L Wang, Z Wu （通讯作者）, Y Wu Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma Journal of Experimental & Clinical Cancer Research 2017 36 (1), 111
Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm, Harald Polzer, Binje Vick, Paul-Albert Koenig, Maria Reinecke, Benjamin Ruprecht, Svenja Petzoldt, Chen Meng, Jana Zecha, Katrin Reiter, Huichao Qiao, Dominic Helm, Heiner Koch, Melanie Schoof, Giulia Canevari, Elena Casale, Stefania Re Depaolini, Annette Feuchtinger, Zhixiang Wu, Tobias Schmidt, Lars Rueckert, Wilhelm Becker, Jan Huenges, Anne-Kathrin Garz, Bjoern-Oliver Gohlke, Daniel Paul Zolg, Gian Kayser, Tonu Vooder, Robert Preissner, Hannes Hahne, Neeme T?nisson, Karl Kramer, Katharina G?tze, Florian Bassermann, Judith Schlegl, Hans-Christian Ehrlich, Stephan Aiche, Axel Walch, Philipp A Greif, Sabine Schneider, Eduard Rudolf Felder, Juergen Ruland, Guillaume Médard, Irmela Jeremias, Karsten Spiekermann, Bernhard Kuster The target landscape of clinical kinase drugs Science 2017 358 (6367), eaan4368
K Chen, F Lv, G Xu, M Zhang, Y Wu, Z Wu （通讯作者） Phosphoproteomics reveals ALK promote cell progress via RAS/JNK pathway in neuroblastoma Oncotarget 2016 7 (46), 75968
J Shi, WJ Wu, G Hu, X Yu, GS Yu, H Lu, ML Yang, B Liu, ZX Wu （通讯作者） Regulation of β-catenin transcription activity by leupaxin in hepatocellular carcinoma Tumor Biology 2016 37 (2), 2313-2320
WJ Wu, J Shi, G Hu, X Yu, H Lu, ML Yang, B Liu, ZX Wu （通讯作者） Wnt/β-catenin signaling inhibits FBXW7 expression by upregulation of microRNA-770 in hepatocellular carcinoma Tumor Biology 2016 37 (5), 6045-6051
Medard G, Pachl F, Ruprecht B, Klaeger S, Heinzlmeir S, Helm D, Qiao H, Ku X, Wilhelm M, Kuehne T , Wu Z, Dittmann A, Hopf C, Kramer K, Kuster, B Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling Journal of proteome research 2015 14 (3), 1574-1586
Wu Z （共同第一作者）, Cheng Z, Sun M, Wan X, Liu P, He T, Tan M, Zhao Y A chemical proteomics approach for global analysis of lysine monomethylome profiling Mol Cell Proteomics 2015 14(2):329-39
G Xu, J Wang, Z Wu, L Qian, L Dai, X Wan, M Tan, Y Zhao, Y Wu SAHA regulates histone acetylation, butyrylation, and protein expression in neuroblastoma Journal of proteome research 2014 13 (10), 4211-4219
AM Gholami, H Hahne, Z Wu （共同第一作者）, FJ Auer, C Meng, M Wilhelm, B Kuster Global proteome analysis of the NCI-60 cell line panel Cell reports 2013 4 (3), 609-620
Z Wu, AM Gholami, B Kuster Systematic identification of the HSP90 regulated proteome Molecular & cellular proteomics 2012 M111. 016675
Zhixiang Wu, Jessica B Doondeea, Amin Moghaddas Gholami, Melanie C Janning, Simone Lemeer, Karl Kramer, Suzanne A Eccles, Susanne M Gollin, Reidar Grenman, Axel Walch, Stephan M Feller, Bernhard Kuster Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer Molecular & Cellular Proteomics 2011 mcp. M111. 011635
Zhixiang Wu, Junfeng Luo, Qinyu Ge, Zuhong Lu Microarray-based Ms-SNuPE: near-quantitative analysis for a high-throughput DNA methylation Biosensors and Bioelectronics 2008 23 (9), 1333-1339
Z Wu, J Luo, Q Ge, D Zhang, Y Wang, C Jia, Z Lu Allele-specific extension on microarray for DNA methylation analysis Analytica chimica acta 2007 603 (2), 199-204