导师姓名： 张拥军 专业代码： 100202
性别： 男 专业名称： 儿科学
培养单位： 附属新华医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： zhangyongjun@sjtu.edu.cn

研究方向 (点击浏览详细信息)
新生儿重症监护

社会任职
中国医师协会儿科医师分会常委
中华医学会儿科分会委员，新生儿学组委员
上海医师协会儿科分会副会长
上海医学会儿科分会副主任委员
中国实用儿科杂志编委，临床儿科杂志编委，儿科药学杂志编委
国家自然科学基金同行评议专家
教育部，上海科技奖评审专家

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** BPD防治的潜在新策略：维生素D抑制宫内炎症诱导的IFN-γ过 表达进而改善BPD的肺泡化阻滞 国家自然科学基金 2018-01~2018-12 20万元 课题负责人
** 探索天然药物单体墨旱莲抑制巨噬细胞焦亡进而改善支气管肺发育不 良病理的机制 国家自然科学基金，面上项目 2017-01~2020-12 57万元 课题负责人
** Csk / Src活性改变导致肺肌成纤维细胞极性破坏在BPD发病中的作用与机制 国家自然科学基金，面上项目 2015-01~2018-12 75万元 课题负责人
** 肺泡化阻滞的新机制：RhoA活性的时空变化介导TGF-a浓度梯度引起的肌成纤维细胞迁移的导向异常 国家自然科学基金，面上项目 2013-01~2016-12 70万元 课题负责人
11ZR** LPS诱导的肺肌成纤维细胞迁移异常致肺泡化阻滞的机制研究 上海自然科学基金 2011-04~2014-04 10万元 课题负责人
新**** 上海交通大学 2010-01~2012-12 15万元 课题负责人
** 苯丙氨酸诱导的Caspase3激活对RhoA切割作用的研究 国家自然科学基金，面上项目 2007-01~2009-12 27万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Lu L, Xia Z, Guo J, Xiao L, Zhang Y （通讯作者） Metabolomics analysis reveals perturbations of cerebrocortical metabolic pathways in the Pahenu2 mouse model of phenylketonuria CNS Neuroscience & Therapeutics 2020 Apr;26(4):486-493
Dongying Zhao#, Xiaohui Gong#, Yahui Li, Xiaoang Sun, Yan Chen, Zhaohui Deng*, Yongjun Zhang* （通讯作者） Effects of cytomegalovirus infection on the differential diagnosis between biliary atresia and intrahepatic cholestasis in a Chinese large cohort study Ann Hepatol . 2020 Nov 12;100286. doi: 10.1016/j.aohep.2020.100286.
Tianwen Zhu#, Xiaohui Gong#, Fei Bei#, Li Ma, Yan Chen, Yonghong Zhang, Xia Wang, Jingjing Sun, Jian Wang, Gang Qiu, Jianhua Sun, Yu Sun*, Yongjun Zhang* （通讯作者） Application of Next-Generation Sequencing for Genetic Diagnosis in Neonatal Intensive Care Units: Results of a Multicenter Study in China Front Genet 2020 Nov 6;11:565078. doi: 10.3389/fgene.2020.565078
Dongying Zhao#, Kejun Zhou#, Yan Chen, Wei Xie, Yongjun Zhang （通讯作者） Development and Validation of Bile Acid Profile-Based Scoring System for Identification of Biliary Atresia: A Prospective Study BMC Pediatr 2020 May 27;20(1):255.
Chen Y#, Zhao D#, Gu S, Li Y, Pan W*, Zhang Y* （通讯作者） Three-color risk stratification for improving the diagnostic accuracy for biliary atresia Eur Radiol 2020 Jul;30(7):3852-3861
Huang H, Tan J, Gong X, Li J, Wang L, Xu M, Zhang X*, Zhang Y* （通讯作者）, Huang L* Comparing Single vs. Combined Cerebrospinal Fluid Parameters for Diagnosing Full-Term Neonatal Bacterial Meningitis. Front Neurol 2019 Jan 23;10:12.
Chen Y#, Zhao D#, Wang B, Zhu J, Zhang J*, Zhang Y*. （通讯作者） Association of intrauterine exposure to aspirin and blood pressure at seven years of age: a secondary analysis. BJOG 2019 Apr;126(5):599-607.
Chen Y,Zhao D,Wang B,Zhu J,Zhang J,Zhang Y （通讯作者） Authors’ reply re: Association of intrauterine exposure to aspirin and blood pressure at 7 years of age: a secondary analysis BJOG 2019 Sep;126(10):1292.
Liu C#, Chen Y#, Zhao D, Zhang J*, Zhang Y* （通讯作者） Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study Front Neuro 2019 Jun 11;10:612
Zhang Y, Huang L, Zhou X, Zhang X, Ke Z, Wang Z, Chen Q, Dong X, Du L, Fang J, Feng X, Fu J, He Z, Huang G, Huang S, Ju X, Gao L, Li L, Li T, Li Y, Liu G, Liu W, Luo X, Nong G, Pan J, Shen K, Song H, Sun J, Mu D, Wang T, Wang B, Xiang W, Yang C, Yang S, Zhao Z, Zhu H, Zhu Y, Zhang J, Little J, Hesketh T, Sun K* Characteristics and Workload of Pediatricians in China. Pediatrics 2019 Jul;144(1):e**.
Yu H, Zou L, He Y, Luo L, Dong W, Zhang Y* （通讯作者）, Lei X* Associations between neonatal serum bilirubin and childhood hypertension PLoS One 2019 Jul 18;14(7):e**
Lei X, Zhao D, Huang L, Luo Z, Zhang J, Yu X*, Zhang Y*. （通讯作者） Childhood Health Outcomes in Term Large-for-Gestational-Age Babies with Different Postnatal Growth Patterns Am J Epidemiol 2018 187(3):507 – 514
Lu L, Ben X, Xiao L, Peng M, Zhang Y. （通讯作者） AMP-activated protein kinase activation in mediating phenylalanine-induced neurotoxicity in experimental models of phenylketonuria. J Inherit Metab Dis 2018 41(4):679-687
Liu C, Chen Z, Li W, Huang L*, Zhang Y* （通讯作者） Vitamin D Enhances Alveolar Development in Antenatal Lipopolysaccharide-Treated Rats through the Suppression of Interferon-γ Production Front. Immunol 2018 Jan 5;8:1923
Ze Chen, Xiaoping Lei,Yongjun Zhang （通讯作者） The effects of fetal gender on pregnancy induced hypertension in twin pregnancy Clinical and Experimental Obstetrics & Gynecology 2018 doi: 10.12891/ceog3978
Zhao D, Zou L, Lei X, Zhang Y. （通讯作者） Gender Differences in Infant Mortality and Neonatal Morbidity in Mixed-Gender Twins. Sci Rep. 2017 18;7(1):8736.
Zha D, Zhang Y* （通讯作者）, Yin Z, Zhao J, Yang D, and Zhou Q Clinical Predictors of Multiple Organ Dysfunction Syndromes in Pediatric patients with Scrub Typhus J Trop Pediatr 2017 63, 167–173
Zhang Y, Zhou J, Zheng W, Lan Z, Huang Z, Yang Q, Liu C, Gao R, Zhang Y. （通讯作者） Clinical, biochemical and molecular analysis of two infants with familial chylomicronemia syndrome Lipids Health Dis 2016 6;15(1):88.
Li J, Li Y, He H, Liu C, Li W, Xie L, Zhang Y. （通讯作者） Csk / Src / EGFR Signaling regulates migration of myofibroblasts and alveolarization. Am J Physiol Lung Cell Mol Physiol. 2016 310 (6): L562–L571
Zhao D, Qiu G, Luo Z, Zhang Y （通讯作者） Platelet Parameters and (1, 3)-β-D-Glucan as a Diagnostic and Prognostic Marker of Invasive Fungal Disease in Preterm Infants PLoS ONE 2015 10(4):e**
Tan J, Kan J, Qiu G, Zhao D, Ren F, Luo Z,Zhang Y （通讯作者） Clinical Prognosis in Neonatal Bacterial Meningitis: The Role of Cerebrospinal Fluid Protein. PLoS ONE 2015 10(10): e**
Ni W, Lin N, He H, Zhu J, Zhang Y （通讯作者） Lipopolysaccharide Induces Up-Regulation of TGF-a through HDAC2 in a Rat Model of BronchopulmonaryDysplasia PLoS ONE 2014 9(3):e91083
Zhao D, Han L, He Z, Zhang J, Zhang Y （通讯作者） Identification of the Plasma Metabolomics as Early Diagnostic Markers between Biliary Atresia and Neonatal Hepatitis Syndrome PLoS ONE 2014 9(1): e85694
He H, Chen F, Ni W, Li J, Zhang Y. （通讯作者） Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation. Mol Med Rep. 2014 10(1):269-75
Li H, Yuan X, Tang J, Zhang Y （通讯作者） Lipopolysaccharide disrupts the directional persistence of alveolar myofibroblast migration through EGF receptor Am J Physiol Lung Cell Mol Physiol 2012 302(6):L569-79.
Zhu L, Li H, Tang J, Zhu J, Zhang Y （通讯作者） Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats Pediatr Pulmonol 2012 47(3):264-74.
Zhang Y （通讯作者）, Zhao J, Wang J, Jiao X Brain-Derived Neurotrophic Factor Inhibits Phenylalanine-Induced Neuronal Apoptosis by Preventing RhoA Pathway Activation Neurochem Res 2010 35(3):480-486.
Zhang Y （通讯作者）, Gu X, Yuan X Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons Eur J Neurosci 2007 25(5):1341-1348.
Zhang Y, Zhang H, Yuan X, Gu X Differential Effects of Phenylalanine on Rac1, Cdc42, and RhoA Expression and Activity in Cultured Cortical Neurons Pediatr Res 2007 62(1):8-13.