导师姓名： 肖永陶 专业代码： 100202
性别： 男 专业名称： 儿科学
培养单位： 附属新华医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 电话EMAIL:YTXIAOCELL@163.COM地址：上海市控江路1665号新华医院科教楼907
邮编： 200092 邮箱地址： YTXIAOCELL@163.COM

研究方向 (点击浏览详细信息)
小儿消化与营养

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 肝细胞源外泌体LncRNA H19调控let-7/LIN28B轴促进胆道闭锁胆管增生的作用机制研究 国家自然科学基金委员会 2020-01~2023-12 55万元 课题负责人
** 长链非编码RNA-BC090353调控IL6表达对胆道闭锁肝内胆管增生机制研究 国家自然科学基金委员会 2018-01~2021-12 54万元 课题负责人
** miR-200a调控p38α信号通路对肠外营养相关肝损害机制研究 国家自然科学基金委员会 2015-01~2017-12 23万元 课题负责人
13ZR** miR-200b调控胆道闭锁肝纤维化进程的分子机制研究 上海市科委 2013-10~2016-10 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xiao Y, Liu R, Li X, Gurley EC, Hylemon PB, Lu Y, Zhou H, Cai W. Long Noncoding RNA H19 Contributes to Cholangiocyte Proliferation and Cholestatic Liver Fibrosis in Biliary Atresia. Hepatology 2019 10.1002/hep.30698
Xiao Y, Lu Y, Wang Y, Yan W, Cai W. Deficiency in intestinal epithelial Reg4 ameliorates intestinal inflammation and alters the colonic bacterial composition. Mucosal Immunol 2019 12(4):919-929
Xiao Y, Zhou Y, Lu Y, Zhou K, Cai W. PHB2 interacts with LC3 and SQSTM1 is required for bile acids-induced mitophagy in cholestatic liver. Cell Death Dis. 2018 9(2):160
Xiao Y, Zhou K, Lu Y, Yan W, Cai W, Wang Y. Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling. Exp Mol Med 2018 50(12):155
Xiao Y, Wang J, Yan W, Zhou K, Cao Y, Cai W. p38α MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure. Cell Death Dis. 2017 8(10):e3110.
Yong-Tao Xiao, Yan WH, Cao Y, Yan JK, Wei Cai Neutralization of IL-6 and TNF-α ameliorates intestinal permeability in DSS-induced colitis Cytokine 2016 83:189-92
Yong-Tao Xiao, Jun Wang, Wei Lu, Yi Cao,Wei Cai. Downregulated expression of microRNA-124 in pediatric intestinal failure patients modulates macrophages activation by inhibiting STAT3 and AChE. Cell Death and Disease 2016 7(12):e2521
Yong-Tao Xiao, Yan W, Zhou K, Cao Y,Wei Cai Glucocorticoid treatment alters systemic bile acid homeostasis by regulating the biosynthesis and transport of bile salts Digestive and Liver Disease 2016 48(7):771-9
Yong-Tao Xiao, Yi Cao, Ke-Jun Zhou, Li-Na Lu, Wei Cai Altered systemic bile acid homeostasis contributes to liver disease in pediatric patients with intestinal failure Scientific reports 2016 6:39264
Yong-Tao Xiao, Zhou Y, Chen Y, Zhou K, Wen J, Wang Y, Wang J, Wei Cai The expression of epithelial-mesenchymal transition-related proteins in biliary epithelial cells is associated with liver fibrosis in biliary atresia Pediatr Res 2015 77(2):310-5
Yong-Tao Xiao, Wang J, Yan W, Zhou Y, Chen Y, Zhou K, Wen J, Wang Y, Wei Cai, Dysregulated miR-124 and miR-200 expression contribute to cholangiocyte proliferation in the cholestatic liver by targeting IL-6/STAT3 signalling. Journal of Hepatology 2015 62(4):889-96
Yong-Tao Xiao, Yan W, Lu L, Wang Y, Lu W, Cao Y, Wei Cai p38/p53/miR-200a-3p feedback loop promotes oxidative stress-mediated liver cell death. Cell Cycle 2015 14(10):1548-58
Yong-Tao Xiao, Wang J, Chen Y, Zhou K, Wen J, Wang Y, Zhou Y, Pan W, Cai W. Up-regulation of miR-200b in biliary atresia patients accelerates proliferation and migration of hepatic stallate cells by activating PI3K/Akt signaling. Cell Signal. 2014 26(5):925-32