摘要/Abstract

α-硫醚化羰基化合物广泛存在于自然界和各行业领域, 是合成杂环的重要中间体, 传统的羰基硫醚合成方法通常需要将底物预功能化, 将其从亲核试剂转化为亲电试剂, 合成方法繁琐复杂, 因此探索一种新型的羰基化合物的硫醚化反应非常重要. 开发了一种在可见光条件下, 利用酮类化合物和硫酚的氧化脱氢偶联反应合成硫醚化合物的方法. 在光催化体系下, 无需任何金属, 该反应使用廉价易得的空气作为氧化剂, 成功实现高原子经济性和广泛的底物适用范围, 为C—S键的直接构建提供了更为简便的方法.
关键词: 可见光诱导, C—S键构建, 脱氢偶联, 硫醚
α-Thioetherified carbonyl compounds widely exist in nature and various industries. They are important intermediates for the synthesis of heterocycles. The traditional synthesis methods of carbonyl thioethers usually need the pre- functionalization of substrates to convert them from nucleophiles to electrophiles. The synthesis methods are cumbersome and complex. Therefore, it is very important to explore a new thioetherification reaction of carbonyl compounds. The synthesis of thioether compounds by oxidative dehydrogenation coupling reaction of ketones and thiophenols under visible light was developed. In the photocatalytic system, without any metal, the reaction successfully realizes high atomic economy and wide substrate application range using cheap and easily available air as oxidant, and provides a simpler method for the direct construction of C—S bond.
Key words: photocatalysis, C—S bond construction, dehydrogenation coupling, thioether


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