摘要/Abstract

报道了一种温和的经由N-羟乙基-N-芳基丙炔酰胺的自位环化及选择性邻位捕捉的方法, 并高效合成了系列含硒苯并[b]吡咯并[2,1-c][1,4]噁嗪-3-酮化合物. 反应无需过渡金属催化, 具有较高的效率和较广的底物适应范围. 该串联环化过程包含了炔烃的α-加成、ipso-环化和螺环中间体的邻位俘获.
关键词: 硒化, 去芳构化, 自位环化, N-羟乙基-N-芳基丙炔酰胺
Facile ipso-cyclization and regioselective ortho-capture of N-hydroxylethyl-N-arylpropiolamides are reported for the synthesis of various selenium-containing benzo[b]pyrrolo[2,1-c][1,4]oxazin-3-ones. The reaction works well with high efficiency and broad reaction scope. In the process, it is believed that α-addition of the propiolamide, sequential ipso-cyclization of the aniline, and regioselective ortho-capture with a hydroxyl group are involved.
Key words: selenization, dearomatization, ipso-cyclization, N-hydroxylethyl-N-phenylpropiolamide


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