摘要/Abstract

报道了一种简单且温和的铜催化萘-1-胺与亚磺酸钠和亚磺酸锂的磺酰化反应. 在反应以碘作为氧化剂, 在比较温和的反应条件下, 可以高选择性地实现萘环C(4)的磺酰化反应, 并且以中等至较高产率生成了各种砜类衍生物.
关键词: 铜催化, 磺酰化, 远程C—H官能团化
A simple and mild copper-catalyzed sulfonylation of naphthalen-1-amine with sodium and lithium sulfinates is reported. In the presence of iodine as oxidant a highly site-selective C—H functionalization at the C(4) position took place. The reaction proceeded readily mild conditions and various sulfones were synthesized in moderate to high yields.
Key words: copper-catalyzed, sulfonylation, remote C—H functionalization


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