摘要/Abstract

色酮化合物因其独特的骨架结构在抗肿瘤、抗菌和抗炎等方面表现出很强的药物活性. 以Cu(OAc)₂为催化剂, CF₃SO₂Na为三氟甲基自由基源, 过氧化叔丁醇(TBHP)为氧化剂, 2-羟基苯基烯胺酮经自由基加成串联环化反应合成了3-三氟甲基色酮, 反应条件温和, 烯胺酮底物具有良好的普适性.
关键词: 自由基加成, 三氟甲基, 烯胺酮, 色酮
Chromones have shown strong drug activity in anti-tumor, antibacterial and anti-inflammatory aspects for their unique skeleton structure. Using Cu(OAc)₂ as catalyst, CF₃SO₂Na as trifluoromethyl radical source, tert-butanol peroxide (TBHP) as oxidant, 3-trifluoromethylchromone was synthesized by radical addition tandem cyclization reaction of 2-hydroxyphenyl enaminone under mild reaction conditions, and enaminone substrate has good functional tolerance.
Key words: radical addition, trifluoromethyl, enaminone, chromones


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