摘要/Abstract

(杂)芳基硼酸及其衍生物在合成化学、材料科学和药物化学领域具有广泛的用途, 因此, 其合成方法研究一直备受关注. 铱催化的C—H硼化反应是合成这类化合物最为有效的途径之一, 然而, 由于反应机理的限制, 区域选择性可控的C—H硼化是铱催化体系的一大挑战, 同时也是该领域的一个重要发展方向. 系统介绍了最近几年铱催化的芳烃远端硼氢化反应的最新进展.
关键词: 碳氢键活化, (杂)芳基硼酸酯, 合成方法, 硼化
(Hetero)Aryl boronic acids and their derivatives have been widely used in synthetic chemistry, material sciences, and drug discovery. Accordingly, the development of novel synthetic methods towards these structures has received a great deal of attention. In particular, Ir-catalyzed C—H borylation represents one of the most efficient methods. Due to the restriction of the reaction mechanism, regioselective controllable C—H borylation of Ir catalysis is a formidable challenge, and it is also an important development direction in this area. In this review, the recent progress in Ir-catalyzed remote selective C—H borylation of arenes is systematically discussed.
Key words: C—H activation, (hetero)aryl boronates, synthetic methods, borylation


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