摘要/Abstract

链霉菌是天然产物的重要来源, 但从土壤来源等普通生态环境筛选出的链霉菌中发现新化合物的比例有所降低. 深海、沙漠、火山或极地属于极端环境, 从中分离出的链霉菌因其特殊气候、地质或营养条件等的差异, 有可能产生较多新颖天然产物. 综述了2009年至2020年来从深海、沙漠、火山或极地链霉菌中发现的155个新天然产物, 介绍了它们的结构和生物活性.
关键词: 链霉菌, 深海, 火山, 沙漠, 天然产物, 生物活性
Streptomyces are important sources of natural products. However, it is more challenging to discover novel compounds from Streptomyces strains isolated from common environmental samples, such as typical soil samples. Due to the unique climates, varying geological and nutrition conditions, deep-sea, desert, volcanic and polar environments are extreme habitats for Streptomyces. These unique habitats are regarded as rare and under-explored niches of new Streptomyces strains and their natural products. The recent advancement of the structures and bioactivities of 155 natural products is reviewed, produced by various Streptomyces strains isolated from these extreme environments from 2009 to 2020.
Key words: Streptomyces, deep-sea, volcano sediments, desert, polar regions, natural products, biological activity


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