摘要/Abstract

在乙酸铵作为催化剂的条件下, 萘酚和多聚甲醛在醋酸溶液中反应, 成功合成了一系列羟基萘甲醛, 收率最高达86%. 将该方法应用于苯酚及取代苯酚的甲酰化反应, 以42%~58%的中等收率得到水杨醛类化合物. 根据反应结果提出了可能的作用机理. 该方法不使用任何金属试剂, 具有反应条件温和、操作简单及成本低廉的特点.
关键词: 萘酚, 苯酚, 多聚甲醛, 甲酰化反应, 绿色合成
The reaction of naphthol and paraformaldehyde in acetic acid solution with ammonium acetate as a catalyst resulted in the synthesis of a series of hydroxynaphthalenes in yields of up to 86%. Several phenols were also transformed into the corresponding salicylaldehydes under the same reaction conditions in moderate yields of 42%~58%. A rational mechanism was also proposed based on the facts of experimental observations. This metal-free process has the advantages of mild reaction conditions, simple operation and low cost.
Key words: naphthol, phenol, paraformaldehyde, formylation reaction, green synthesis


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