摘要/Abstract
报道了无金属参与的连续的催化型Ugi三组分/炔烃-叠氮环加成反应一锅合成[1,2,3]三唑并[1,5- a]喹喔啉. 该反应使用邻叠氮基芳胺、炔醛以及异腈为原料, 在磷酸催化下发生催化型Ugi三组分反应, 随后在甲苯中加热发生环加成反应以55%~85%的收率得到[1,2,3]三唑并[1,5- a]喹喔啉.
关键词: 一锅, 无金属, [1,2,3]三唑并[1,5-a]喹喔啉, Ugi三组分, 炔烃-叠氮环加成
A new one-pot metal-free preparation of [1,2,3]triazolo[1,5- a]quinoxalines by a Ugi-3CR/alkyne-azide cycloaddition sequence has been developed. The reaction of 2-azidobenzenamines, propiolic aldehydes and isocyanides produced [1,2,3]triazolo[1,5- a]quinoxalines in 55%~85% yields via sequential Ugi-3CR/alkyne-azide cycloaddition reaction in the presence of H3PO4 and heating in toluene respectively.
Key words: one-pot, metal-free, [1,2,3]triazolo[1,5-a]quinoxaline, Ugi-3CR, alkyne-azide cycloaddition
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