摘要/Abstract

有机硼化物是一类重要的有机合成中间体. 以分子筛负载铜为催化剂, 在水相中温和的条件下, 实现α,β-不饱和化合物的共轭硼化反应, 建立了一种制备β-硼取代化合物的直接有效的新方法. 该方法操作简单, 底物普适性好, 可适用于不同类型取代的底物, 均以较高收率得到目标产物. 催化剂在反应结束后可通过离心分离回收, 循环使用7次后依然保持较高的催化反应活性.
关键词: 分子筛负载铜, α,β-不饱和化合物, 水相, 回收再利用
An eco-friendly zeolite immobilized copper catalyzed cojugate borylation of α,β-unsaturated compounds which was accomplished in aqueous media under mild conditions was reported. This method provided a direct and efficient pathway to achieve an important class of β-borylated compounds. Desired products were obtained in good to excellent yields with broad substrate scope. The advantages of this newly developed method include operational simplicity, mild conditions, good functional group tolerance and recyclability of catalyst. Remarkably, this zeolite supported copper catalyst could be recovered easily by simple centrifugation and reused for seven times without any significant decrease of catalytic activity.
Key words: zeolite immobilized copper, α,β-unsaturated compound, aqueous media, recycle and reuse


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