摘要/Abstract

报道了HBr催化下以水为氢源的α-溴代甲基酮类化合物的脱溴化反应. 以α-溴代甲基酮类化合物为原料, 四氢呋喃为溶剂, α-溴代甲基酮与质量分数5%的氢溴酸的物质的量比为1.0:0.2时, 在180 ℃下反应5~14 h, 分离产率高达94% [高效液相(HPLC)产率96%]的脱溴产物. 该方法无金属催化剂参与, 催化剂价格低廉, 所有产物均经¹H NMR和¹³C NMR结构确证.
关键词: α-溴代甲基酮类化合物, HBr, 脱溴
The debromination reaction of α-bromomethylketone compounds was achieved by using water as the hydrogen source under the catalysis of HBr. Using α-bromomethylketones as raw materials, tetrahydrofuran as solvent, when the molar ratio of α-bromomethylketone to 5% mass fraction hydrobromic acid was 1.0:0.2, the debrominated product could be obtained with a isolated yield of 94% [high performance liquid chromatography (HPLC) yield 96%] by reacting at 180 ℃ for 5~14 h. All products were confirmed by¹H NMR and ¹³C NMR spectra.
Key words: α-bromomethylketone, HBr, debromination


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