摘要/Abstract

从深海真菌Diaporthe phaseolorum FS459中分离出10个聚酮化合物,包括3个新的色酮衍生物(1、2和5),一对新的差向异构体混合物(3和4), 1个新的Azaphilone类似物(6)及4个已知的化合物(7~10). 它们的结构是基于综合波谱分析进行确定, 同时其绝对构型通过对比实测电子圆二色谱(ECD)曲线与量子化学计算得出的理论值来确定. 化合物1~4具有罕见的2?,3?-二甲基二氧戊环结构单元. 此外, 本研究还评估了化合物1~10的体外细胞毒性、抗菌活性及NO产生的抑制效果.
关键词: 聚酮, 深海真菌, Diaporthe phaseolorum, 细胞毒
Ten polyketides, including three new chromone derivatives (1, 2 and 5), a pair of new epimer mixtures (3 and 4), a new azaphilone analogue (6) and four known compounds (7~10) were isolated from the deep-sea-derived fungus Diaporthe phaseolorumFS459. Their structures were elucidated by extensive spectroscopic analysis, while the absolute configurations were established by comparison of experimental and quantum chemical calculated electronic circular dichroism (ECD) spectra. Compounds 1~4 possessed a rare 2?,3?-dimethyl-dioxolane moiety. Thein vitro cytotoxicity, antibacterial activities and NO production inhibitory effects of compounds 1~10 were evaluated.
Key words: polyketides, deep-sea-derived fungus, Diaporthe phaseolorum, cytotoxicity


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