摘要/Abstract

发展了一种由锰介导的简易高效的Reformatsky催化体系. 在便宜易得锰粉的介导下, 实现了镍催化剂高效催化碘代乙酸乙酯与醛酮的Reformatsky反应. 以乙腈为反应溶剂, 温和条件下可获得高收率的Reformatsky加成产物(up to 98%). 此外, 该催化方法学还可放大至克级规模.
关键词: 锰, 镍催化剂, Reformatsky, 醛酮, β-羟基链烷酸酯
A practical, flexible, and efficient manganese-mediated catalytic system of Reformatsky reaction has been described. The cheap and readily available manganese powder acts as the reaction mediator, which conducts effectively for the preparation of useful β-hydroxyalkanoate compounds with the nickel catalyst in excellent yields (up to 98%) and mild condition. In addition, the catalytic methodology can be scaled up to the gram scale.
Key words: manganese, nickel catalyst, reformatsky, aldehydes and ketones, β-hydroxyalkanoates


PDF全文下载地址:

点我下载PDF