摘要/Abstract
稳定、安全、便捷、高效的亲电二氟甲基化试剂的发展和应用是当前有机氟化学的热门研究领域.在过去的十几年里，由于新试剂和新方法的发展，亲电二氟甲基化反应取得了一定的进展.亲电二氟甲基试剂可以方便地向分子的富电子位点引入二氟甲基，同时还可以被还原作为二氟甲基自由基前体参与反应，因此在含氟化合物的合成上具有明显的优势.但是与亲核二氟甲基试剂及应用研究相比，仍然存在很大的发展空间.全面总结了过去十几年亲电型二氟甲基试剂的研究进展，从总体上介绍了亲电型二氟甲基试剂在氟化学中的应用和重要性，按试剂类型着重介绍和讨论了亲电型二氟甲基试剂的类型，参与的亲电二氟甲基化反应及其作为二氟甲基自由基前体的反应.
关键词: 亲电二氟甲基试剂, 亲电二氟甲基化反应, 自由基二氟甲基化反应, 二氟卡宾
In the past two decades, the development and application of bench-stable electrophilic difluoromethylating reagents have attracted considerable attention. Consequently, some progress in this area has been ongoing recently. Electrophilic difluoromethylating reagents play a very important role in the synthesis of fluorine-containing compounds, due to their capability of readily transferring difluoromethyl moiety (CF2H) into wide range of nucleophiles, as well as being used as difluoromethyl radical(•CF2H) precursorfor radical difluoromethylations. However, the electrophilic difluoromethylating reagents and application therein remain still underdeveloped in comparison with nucleophilic ones. The research advance in electrophilic difluoromethylating reagents in past two decades is reviewed.
Key words: electrophilic difluoromethylating reagent, electrophilic difluoromethylation reaction, radical difluoromethylation reaction, difluorocarbene
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