摘要/Abstract

近年来，有机氟化学领域迅猛发展，氟化及含氟官能团化反应受到有机化学家的高度关注.含氟官能团具有特殊的理化性质，将其引入药物分子会提高药物分子的生物活性.其中三氟甲氧基具有较强的吸电子性和高亲脂性，含有三氟甲氧基的化合物在医药和农药等领域发挥着重要的作用.近年，一些富有创新性的策略被用于合成含有三氟甲氧基的化合物.重点论述了我们研究小组在三氟甲氧基化反应领域的研究成果，并讨论了三氟甲氧基化反应所面临的一些挑战.
关键词: 三氟甲氧基化, 苯磺酸三氟甲酯(TFMS), (E)-O-三氟甲基苯甲醛肟(TFBO)
In recent years, the field of organic fluorine chemistry has developed rapidly. Fluorination and fluorine-containing functionalization reactions have attracted extensive attention of organic chemists due to their special physical and chemical properties. The introduction of fluorine-containing group into drug molecules can improve the biological activity of drug molecules. Trifluoromethoxy group has strong electron absorption and high lipophilicity, compounds containing trifluoromethoxy play an important role in the fields of medicine, pesticides and materials. In recent years, some innovative strategies have been used to synthesize compounds containing trifluoromethoxy group. This account mainly focuses on the research of trifluoromethoxy reaction in our group, and some challenges faced by trifluoromethoxy reaction.
Key words: trifluoromethoxylation, trifluoromethyl aryl sulfonate (TFMS), (E)-O-trifluoromethyl-benzaldoximes (TFBO)


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