摘要/Abstract

主客体相互作用是超分子自组装过程中最重要的作用方式之一，常被用于构建多功能超分子材料.基于主客体相互作用，利用具有聚集诱导发光性质的大环主体分子或客体分子作为自组装基元，构筑具有聚集诱导发光效应的超分子体系，并将其应用于药物递送、细胞成像、生物传感等生物领域，已成为超分子化学的研究热点.从超分子组装体的发光效应分别源于主体分子和客体分子两方面，介绍了近五年来以环糊精、杯芳烃、葫芦脲、柱芳烃及其它大环为主体化合物，基于主客体作用构筑的聚集诱导发光超分子组装体，并对其在生物医用领域的研究进展进行了简要综述.
关键词: 主客体作用, 自组装, 聚集诱导发光, 细胞成像, 药物转运
Host-guest interaction, as one of the most important behaviors in supramolecular self-assemblies, is often used to construct functional supramolecular materials. Based on host-guest interaction, it has become a hotspot in supramolecular chemistry by utilizing macrocyclic hosts and guests with aggregation-induced emission (AIE) properties as building blocks to construct supramolecular system, which can be widely used in drug delivery, cellular imaging, biosensing and so on. According to the origination of fluorescence effects of supramolecular assemblies, either from the host or guest molecules, the recent 5-year advances of AIE supramolecular self-assemblies based on host-guest interaction by utilizing macrocycles such as cyclodextrin, calixarene, cucurbituril, pillararene and other water-soluble host molecules are summarized, and their applications in the biomedical field are discussed.
Key words: host-guest interaction, self-assembly, aggregation-induced emission, cell imaging, drug delivery


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