摘要/Abstract

开发了一种两步一锅法高效合成1，2，2-三碘代烯烃类化合物的新方法.在γ-三氧化二铝的活化作用下，N-碘代丁二酰亚胺和碘与端基炔烃发生两次碘代反应.本方法具有中等到较高收率，底物普适性较好，所使用的催化剂廉价无毒.
关键词: 端基炔烃, 碘代, 三氧化二铝, 1,2,2-三碘代烯烃类化合物, 一锅法
A simple two-step, one-pot synthesis of 1,2,2-triiodovinyl derivatives from terminal alkynes using N-iodosuc-cinimide and iodine as precursors, activated with γ-aluminum oxide is developed. This approach resulted in moderate to excellent yields, good functional group tolerance and utilization of an inexpensive catalyst.
Key words: terminal alkyne, iodination, aluminum oxide, 1,2,2-triiodovinyl derivative, one-pot process


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