摘要/Abstract

β，γ-不饱和α-酮酸酯是一种多官能团的合成子，其1，2-双羰基的结构便于进行活化和手性控制，多个反应位点可以进行多样的反应设计.近20年来，许多手性路易斯酸催化剂和有机小分子催化剂被应用到β，γ-不饱和α-酮酸酯参与的不对称催化反应中，得到了各种光活性化合物.根据β，γ-不饱和α-酮酸酯中的β，γ-不饱和α-酰基共轭体系、碳碳双键及羰基三种不同的反应位点分类，对近几年来β，γ-不饱和α-酮酸酯在不对称催化中的应用进展进行综述.同时对存在的局限性和未来的发展趋势进行了展望.
关键词: β,γ-不饱和α-酮酸酯, 不对称催化, 应用
β,γ-Unsaturated α-ketoester is a class of polyfunctional synthon. Due to its 1,2-dicarbonyl structure and multiple reactive sites, it has been used for the synthesis of various compounds. In the past twenty years, a number of chiral Lewis acid catalysts and organocatalysts have been applied to asymmetric catalytic reactions using β,γ-unsaturated α-ketoesters and various optically active compounds have been synthesized. The current progress of β,γ-unsaturated α-ketoesters in asymmetric catalysis according to the three different reaction sites, unsaturated acyl conjugate system, carbon-carbon double bond and carbonyl group, is summarized. Finally, the limitation of related reactions and the future development trends are also pointed out.
Key words: β,γ-unsaturated α-ketoester, asymmetric catalysis, application


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