摘要/Abstract
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主要研究了苯硒酚基铁氢配合物cis-[(ArSe)FeH(PMe3)4] [Ar=Ph (1), p-MeOC6H4 (2)和o-MeC6H4 (3)]对一级酰胺脱水成腈的催化作用. 实验证明当选用(EtO)3SiH为还原剂时, 在较为温和的条件下这三种配合物均对一级酰胺脱水为腈的过程都具有良好的催化作用. 该催化体系对于芳基酰胺中苯环上的取代基具有很好的耐受性. 与斥电性基团相比, 吸电性基团对该催化反应比较有利.
关键词: 铁氢配合物, 硒酚, 硒配位, 酰胺脱水, 腈制备
Three cis-selenophenolato iron hydrides [cis-[(ArSe)FeH(PMe3)4] (Ar=Ph (1), p-MeOC6H4 (2) and o-MeC6H4 (3)], were used as catalysts for the dehydration of primary amides to nitriles. The experimental results show that three complexes have good catalytic effect on reductive dehydration of primary amide to nitrile under mild conditions using (EtO)3SiH as reducing agent. The catalytic system is well tolerated to the substituents on the benzene ring in aromatic amides. Compared with electron-donating group, electron-withdrawing group is more advantageous to the catalytic reaction.
Key words: iron hydride, selenophenol, Se-coordination, reductive amide dehydration, nitrile preparation
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