摘要/Abstract

酰胺类化合物广泛存在于天然产物、药物和生物活性分子中，酰胺键的形成反应是有机化学最重要的反应之一，贝克曼重排反应是合成伯酰胺和仲酰胺的重要方法.近年来，许多新的催化体系被建立，包括从醛、酮甚至是醇出发的一锅法反应.主要综述了近五年来贝克曼重排的研究进展及其应用.
关键词: 贝克曼重排, 酰胺, 合成, 肟
Amide motifs are prevalent structures found in natural products, pharmaceuticals, and bioactive compounds. Amide bond formations are the most important transformations in organic chemistry. Beckmann rearrangement is a significant method for the synthesis of primary and secondary amides. Recently, diversified new catalytic protocols were developed, including one-pot reaction from the corresponding aldehydes and ketones, or even from alcohols. The progress and applications of Beckmann rearrangement in recent five years are reviewed.
Key words: Beckmann rearrangement, amides, synthesis, oximes


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