摘要/Abstract

内质网作为亚细胞器在哺乳细胞生命活动中发挥重要作用.将内质网可视化，进一步检测其活性物质、微环境及生理过程，对于疾病的诊治具有重要的指导价值.近年来，内质网靶向荧光探针的设计与合成受到了越来越多的关注.当前已报道的内质网靶向荧光探针涵盖了单纯内质网成像、金属离子、小分子物质、大分子物质、微环境等.总结并介绍了近期报道的内质网靶向荧光探针的设计与合成工作，分析了内质网荧光探针在研究细胞生理过程中的应用，并展望了内质网靶向荧光探针的发展趋势.
关键词: 内质网, 荧光, 成像, 探针, 活性小分子
The endoplasmic reticulum, a subcellular organelle, plays an important role in the life activities of mammalian cells. Therefore, visualizing the endoplasmic reticulum, and further examining its active substances, microenvironments and physiological processes have important guiding value for the diagnosis and treatment of related diseases. In recent years, the design and synthesis of endoplasmic reticulum-targetable fluorescent probes have received more and more attentions. Currently, reported endoplasmic reticulum-targetable fluorescent probes mainly include simple endoplasmic reticulum imaging, metal ions, small molecule material, big molecule material, microenvironments, etc. This article summarizes and describes the design and synthesis of the reported endoplasmic reticulum-targetable fluorescent probes, analyzes the application of endoplasmic reticulum fluorescent probes in the study of cellular physiological processes, and prospects the development trend of endoplasmic reticulum-targetable fluorescent probes.
Key words: endoplasmic reticulum, fluorescence, imaging, probe, active small molecule


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