摘要/Abstract

将多样性导向合成策略应用于3-乙酰基-4-苯基-1-氧代螺[4，5]癸-3-烯-2-酮的羰基多样化衍生，合成了一系列结构新颖的3-乙酰基-4-苯基-1-氧代螺[4，5]癸-3-烯-2-酮衍生物.活体及离体生物活性实验结果表明，一些化合物对植物病原菌显示出优异的杀菌活性，如3-（1-烯丙氧基乙基）-4-苯基-1-氧代螺[4，5]癸-3-烯-2-酮（7）在400 μg/mL浓度下对黄瓜霜霉病和玉米锈病的抑制率均为100%.
关键词: 多样性导向合成, 3-乙酰基-4-苯基-1-氧代螺[4,5]癸-3-烯-2-酮, 杀菌活性, 植物病原菌
The diversity-orientied synthesis strategy was utilized to diversely derive from the carbonyl of 3-acetyl-4-phenyl-1-oxaspiro[4,5]dec-3-en-2-one, a series of novel 3-acetyl-4-phenyl-1-oxaspiro[4,5]dec-3-en-2-one derivatives were synthesized. The preliminary in vivo and in vitro bioassay results showed that some compounds exhibited excellent fungicidal activity against phytopathagens, such as 3-allyloxyethyl-4-phenyl-1-oxaspiro[4,5]dec-3-en-2-one (7) had 100% control rates against Pseudoperonospora cubensis and Puccinia polysora at the concentration of 400 μg/mL.
Key words: diversity-orientied synthesis, 3-acetyl-4-phenyl-1-oxaspiro[4,5]dec-3-en-2-one, fungicidal activity, phytopathagen


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