摘要/Abstract

从α-溴代酮与磺酰氯出发，发展了一种高效的还原偶联反应.在温和的条件下，能以良好到优秀的收率得到结构多样的β-酮砜类化合物.该方法实用且操作简单，无需严格去除空气和水，能放大到克级规模.
关键词: β-酮砜, α-溴代酮, 磺酰氯, 还原偶联, 锰
A mild and highly efficient reductive coupling of α-bromoketones with sulfonyl chlorides is described. Various β-ketosulfones can be obtained under mild conditions in good to excellent yields. This method provides a simple and practical access to β-ketosulfones and is amenable to gram scale with no special precautions to exclude air or moisture.
Key words: β-ketosulfones, α-bromoketones, sulfonyl chlorides, reductive coupling, manganese


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