删除或更新信息,请邮件至freekaoyan#163.com(#换成@)

联苯骨架手性双咪唑啉配体的合成及在不对称环丙烷化中的应用

本站小编 Free考研考试/2022-02-14

摘要/Abstract



一系列含有轴手性和中心手性的联苯双咪唑啉配体被首次合成.相较于传统的策略,Ullmann偶联方法表现出更高的反应效率,尤其对于含有叔丁基的配体.得到的配体被进一步应用于在铜催化下的不对称环丙烷化.
关键词: 咪唑啉, 轴手性, 中心手性, 不对称环丙烷化
A serial of biphenyl bisimidazolines containing both axial and central chirality have been synthesized for the first time. Compared with common method, Ullmann coupling methodology exhibited superior performance expecially for t-Bu substituted ligands. The obtained ligands were further applied in the Cu-catalyzed asymmetric cyclopropanation.
Key words: imidazoline, axial chirality, central chirality, asymmetric cyclopropanation


PDF全文下载地址:

点我下载PDF
相关话题/咪唑 丙烷 不对称 联苯 中心