xm:张乃霞
xb:女
zc:研究员
xl:博士
dh:
cz:
dzyj:nxzhang@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长
txdz:上海市浦东新区张江高科技园区祖冲之路555号
grjj: 张乃霞博士1998年毕业于北京医科大学，获理学学士学位。2003年毕业于中国科学院上海有机化学研究所，获有机化学博士学位。2004年以博士后身份赴美国明尼苏达大学留学，2008年获聘为明尼苏达大学研究助理教授，2010年10月加入中国科学院上海药物研究所工作至今，现任中国科学院上海药物研究所研究员、所级公共技术服务中心核磁技术服务部首席技术专家、课题组长、博士生导师。张乃霞博士长期致力于基于NMR技术的蛋白质-蛋白质、蛋白质-小分子相互作用研究，主持建立了基于核磁共振技术的蛋白质-蛋白质相互作用研究平台、基于核磁共振技术的蛋白质-活性化合物相互作用研究平台、以及基于核磁共振代谢组学技术的药效学、药理学和毒理学研究平台。主持国家自然科学基金、中国科学院仪器设备功能开发技术创新项目等多个国家和省部级科研课题。已发表SCI学术论文60余篇，文章引用1300余次。

教育经历

09/01/1994-07/31/1998，北京医科大学，药学院，学士

09/01/1998–07/31/2003，中国科学院上海有机化学研究所，生命有机化学国家重点实验室，博士，导师：吴厚铭 研究员

yjfx:基于核磁共振技术的蛋白质-蛋白质和蛋白质-小分子相互作用研究；基于核磁共振代谢组学技术的药效学、药理学和毒理学研究。
dblz:1.Zhou, C.#, Zhang, C.#, Zhu, H.#, Liu, Z., Su, H., Zhang, X., Chen, T., Zhong, Y., Hu, H., Xiong, M., Zhou, H., Xu, Y.*, Zhang, A.*, Zhang, N.*, Allosteric Regulation of Hsp90α\'s Activity by Small Molecules Targeting the Middle Domain of the Chaperone, iScience, 23(2), 100857, 2020.

2.Xiao, R.#, Ding, C.#, Zhu, H., Liu, X., Gao, J., Liu, Q., Lu, D., Zhang, N.*, Zhang, A.*, Zhou, H.*, Suppression of Asparagine Synthetase Enhances the Antitumor Potency of ART and Artemalogue SOMCL-14-221 in Non-Small Cell Lung Cancer, Cancer Letters, 475, 22-33, 2020

3.Yang, Y., Ding, Y., Zhou, C., Wen, Y., Zhang, N.*, Structural and Functional Studies of USP20 ZnF-UBP Domain by NMR, Protein Science, 28(9), 1606-1619, 2019

4.Liu, X.#, Wang, W.#, Chen, H., Zhang, H.*, Zhang, N.*, Interplay Between Alzheimer\'s Disease and Global Glucose Metabolism Revealed by the Metabolic Profile Alterations of Pancreatic Tissue and Serum in APP/PS1 Transgenic Mice, Acta Pharmacologica Sinica, 40(10), 1259-1268, 2019

5.Chen, D.#, Chen, Y.#, Lian, F.#, Chen, L., Li, Y., Cao, D., Wang, X., Chen, L., Li, J., Meng, T., Huang, M.*, Geng, M., Shen, J., Zhang, N.*, Xiong, B.*, Fragment-based Drug Discovery of Triazole Inhibitors to Block PDEδ-RAS Protein-Protein Interaction, European Journal of Medicinal Chemistry, 163, 597-609, 2019

6.Hou, X.#, Wang, M.#, Wen, Y.#, Ni, T., Guan, X., Lan, L., Zhang, N.*, Zhang, A.*, Yang, C.*, Quinone skeleton as a new class of irreversible inhibitors against Staphylococcus aureus sortase A, Bioorganic & Medicinal Chemistry Letters, 28(10), 1864-1869, 2018

7.Yang, Y.#, Shi, L.#, Ding, Y., Shi, Y., Hu, H., Wen, Y.*, Zhang, N.*, Structural and Functional Investigations of the N-Terminal Ubiquitin Binding Region of Usp25, Biophysical Journal, 112(10), 2099-2108, 2017

8.Yu, J.#, Chen, T.#, Zhou, C.#, Lian, F., Tang, X., Wen, Y., Shen, J., Xu, Y., Xiong, B.*, Zhang, N.*, NMR-based Platform for Fragment-Based Lead Discovery Used in Screening BRD4-targeted Compounds, Acta Pharmacologica Sinica, 37(7), 984-93, 2016

9.Zhang, T.#, Wang, W.#, Huang, J., Liu, X.*, Zhang, H.*, Zhang, N.*, Metabolomic Investigation of Regional Brain Tissue Dysfunctions Induced by Global Cerebral Ischemia, BMC Neuroscience, 17(1), 25, 2016

10.Ma, H.#, Liu, X.#, Wu, Y.*, Zhang, N.*, The Intervention Effects of Acupuncture on Fatigue Induced by Exhaustive Physical Exercises: A Metabolomics Investigation, Evidence-based Complementary and Alternative Medicine, 2015, 508302, 2015

11.Zhang, H.#, Zhou, C.#, Chen, W., Xu, Y., Shi, Y., Wen, Y.*, Zhang, N.*, A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain, Scientific Reports, 5, 9542, 2015

12.Wen, Y.#, Shi, L.#, Ding, Y., Cui, R., He, W.T., Hu, H.*, Zhang, N.*, The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights, Biochemical Journal, 471(2), 155-65, 2015

13.Zhang, N.#, Wang, Q.#, Ehlinger, A.#, Randles, L.#, Lary, J.W., Kang, Y., Haririnia, A., Storaska, A.J., Cole, J.L., Fushman, D., Walters, K.J.*, Structure of the S5a:K48-linked diubiquitin complex and its interactions with Rpn13, Molecular Cell, 35(3), 280-290, 2009

14.Husnjak, K.#, Elsasser, S.#, Zhang, N.#, Chen, X., Randles, L., Shi, Y., Hofmann, K., Walters, K.J.*, Finley, D.*, Dikic, I.*, Proteasome subunit Rpn13 is a novel ubiquitin receptor, Nature, 453(7194), 481-488, 2008

jyjl:09/01/1994-07/31/1998北京医科大学，药学院，学士