xm:张继稳
xb:男
zc:研究员
xl:博士
dh:
cz:
dzyj:jwzhang@simm.ac.cn
grzy:
zjlb:研究员
zw:课题组长
txdz:上海市浦东新区张江高科技园区海科路501号
grjj: 张继稳，博士，中国科学院上海药物研究所研究员、课题组长、博士研究生导师。带领课题组与国内外合作研究团队开展跨学科合作研究，致力于在制剂结构和药物动力学特征上阐明给药系统从分子到宏观结构的释放机理。针对药物制剂结构的复杂性，以同步辐射光源定量研究方法为主，发展了药物释放系统复杂结构、动态结构的定量表征方法，发现和设计了笼状片剂、新型结构渗透泵等新剂型，提出了结构药剂学新理论；以环糊精金属有机骨架等新材料为主，开展超分子给药系统研究，发展了超分子给药系统的释放机制相关的动力学速率常数高效液相色谱表征方法和分子模拟预测方法；围绕给药系统的评价，发展了缓控释制剂药物动力学理论，提出缓控释制剂优化设计的量化方法，设计了仿生给药系统等新剂型。已培养博士5名，硕士40余名；现指导博士研究生2名，硕士研究生20名，其中，留学生4名。

yjfx:1.结构药剂学理论与应用研究；
2.超分子给药系统研究；
3.缓控释制剂研发。
dblz:(1) Liu Zhang, Li Wu, Caifen Wang, Guoqing Zhang, Lin Yu, Haiyan Li, Abi Maharjan, Yan Tang, Dunwei He, Peter York, Huimin Sun, Xianzhen Yin*, Jiwen Zhang*, Lixin Sun*. Synchrotron Radiation Microcomputed Tomography Guided Chromatographic Analysis for Displaying the Material Distribution in Tablets. Analytical Chemistry, 2018, DOI: 10.1021/acs.analchem.7b04726
(2) Haiyan Li, Nana Lv, Xue Li, Botao Liu, Jing Feng, Xxiaohong Ren, Tao Guo, Dawei Chen, Fraser Stoddart J*, Ruxandra Gref*, Jiwen Zhang*. Composite CD-MOF nanocrystals-containing microspheres for sustained drug delivery, Nanoscale, 2017, 9(22): 7454-7463
(3) Vikramjeet Singh, Tao Guo, Haitong Xu, Li Wu, Jingkai Gu, Chuanbin Wu, Ruxandra Gref*, Jiwen Zhang*. Moisture resistant and biofriendly CD-MOF nanoparticles obtained via cholesterol shielding, Chemical Communications, 2017, 53(66): 9246-9249
(4) Parbeen Singh, Xiaohong Ren, Tao Guo, Li Wu, Shailendra Shakya, Yaping He, Caifen Wang, Abi Maharajan, Vikramjeet Singh*, Jiwen Zhang*. Biofunctionalization of β-cyclodextrin nanosponges using cholesterol. Carbohydrate Polymers, 2018, DOI: https://doi.org/10.1016/j.carbpol.2018.02.044
(5) Longwei Fang, Xianzhen Yin, Li Wu, Yaping He, Yuanzhi He, Wei Qin, Fanyue Meng, Peter York, Xu Xu*, Jiwen Zhang*. Classification of microcrystalline celluloses via structures of individual particles measured by synchrotron radiation X-ray micro-computed tomography, International Journal of Pharmaceutics, 2017, 531(2): 658-667
(6) Xue Li, Tao Guo, Laurent Lachmanski, Francesco Manoli, Mario Menendez-Miranda, Ilse Manet, Zhen Guo, Li Wu, Jiwen Zhang*, Ruxandra Gref*. Cyclodextrin-based metal-organic frameworks particles as efficient carriers for lansoprazole: Study of morphology and chemical composition of individual particles, International Journal of Pharmaceutics, 2017. 531(2): 424-432
(7) Nana Lv, Tao Guo, Botao Liu, Caifen Wang, Vikaramjeet Singh, Xiaonan Xu, Xue Li, Dawei Chen*, Ruxandra Gref*, Jiwen Zhang*. Improvement in Thermal Stability of Sucralose by γ-Cyclodextrin Metal-Organic Frameworks, Pharmaceutical Research, 2017, 34(2): 269-278
(8) Botao Liu, Yaping He, Liping Han, Vikramjeet Singh, Xiaonan Xu, Tao Guo, Fanyue Meng, Xu Xu, Peter York, Zhaoxin Liu*, Jiwen Zhang*. Microwave-Assisted Rapid Synthesis of gamma-Cyclodextrin Metal-Organic Frameworks for Size Control and Efficient Drug Loading, Crystal Growth & Design, 2017, 17(4): 1654-1660
(9) Xiaonan Xu, Caifen Wang, Haiyan Li, Xue Li, Botao Liu, Vikramjeet Singh, Shuxia Wang, Lixin Sun*, Ruxandra Gref*, Jiwen Zhang*. Evaluation of drug loading capabilities of gamma-cyclodextrin-metal organic frameworks by high performance liquid chromatography, Journal of Chromatography A, 2017, 1488: 37-44
(10) Tao Guo, Haiyan Li, Li Wu, Zhen Guo, Xianzhen Yin, Caifen Wang, Lixin Sun, Qun Shao, Jingkai Gu, Peter York, Jiwen Zhang*. Prediction of Rate Constant for Supramolecular Systems with Multiconfigurations, Journal of Physical Chemistry A, 2016, 120(7): 981–991

jyjl:1997-2001沈阳药科大学，药剂学，研究生/博士