xm:蒋华良
xb:男
zc:研究员
xl:博士
dh:
cz:
dzyj:hljiang@simm.ac.cn
grzy:
zjlb:院士；研究员；****；新药；
zw:中国科学院院士、研究组长、博士生导师
txdz:上海市浦东新区张江高科技园区祖冲之路555号
grjj:蒋华良长期致力药学基础研究和新药研发，他通过生物学、化学和计算科学等多学科的交叉，开展原创药物研究新策略与新方法、先导化合物发现和优化、药物靶标调控机制等研究。他发展了一系列靶标发现和药物设计新方法，被国际同行高度重视和应用，推动我国该领域研究水平进入国际前沿。他发展了能预测化合物药效的理论计算方法，解决了药物设计领域的重大难题。他针对多种重要靶标发现了数十个新结构类型的先导化合物，其中1个抗勃起功能障碍候选药物已进入临床试验，5个抗2型糖尿病等疾病的候选新药正处于临床前研究。迄今他在国际学刊上发表了通讯作者论文200余篇、综述10篇；合编专著16本，译著2本；被他引6000余次。申请专利115项，已授权35项，实现成果转让3项（合同金额达1.8亿）。获国家自然科学二等奖、何梁何利科技进步奖等多种奖项。目前担任J. Med. Chem.副主编和其他5种国际学刊的编委。蒋华良长期担任863计划、973计划和国家基金委重大研究计划专家组成员，具有较强的组织协调和团队管理能力。此外，蒋华良还是一位优秀的战略科学家，曾承担科技部、基金委和中科院多项战略研究任务，相关成果被纳入《国家中长期发展规划》、基金委重大研究计划和中科院创新2020计划，主编专著1本。
yjfx:主要研究方向为药物分子设计。近年主要开展离子通道、酪氨酸激酶、脂质代谢相关通路、新型抗菌(病毒)靶标及表观遗传学相关重要蛋白质的靶标发现、分子动力学模拟、计算机辅助药物设计，药物设计方法、ADME/T预测方法和生物信息学研究。
dblz:(2009.1.1-)
1. Jie Zhang, Hongchuan Liu, Kongkai Zhu,Shouzhe Gong, Shaynoor Dramsi, Ya-Ting Wang, Jiafei Li, Feifei Chen, Ruihan Zhang, Lu Zhou, Lefu Lan, Hualiang Jiang, Olaf Schneewind*, Cheng Luo*, Cai-Guang Yang*. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase. Proceedings of the National Academy of Sciences U.S.A. In press. 2. Mingyue Zheng, Xian Liu, Yuan Xu, Honglin Li, Cheng Luo, Hualiang Jiang*. Computational methods for drug design and discovery: focus on China. Trends in Pharmacological Sciences 2013, 10, 549-559 3. Fang Bai, Yechun Xu, Jing Chen, Qiufeng Liu, Junfeng Gu, Xicheng Wang Jianpeng Ma, Honglin Li*, José Nelson Onuchic*, Hualiang Jiang*. Free energy landscape of the binding process of Huperzine A to acetylcholinesterase. Proceedings of the National Academy of Sciences U.S.A. 2013, 110, 4273–4278 4. Ping Li, , Zhuxi Chen, Haiyan Xu, Haifeng Sun, Hao Li, Hong Liu, Huaiyu Yang*, Zhaobing Gao*, Hualiang Jiang*, Min Li. The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands. Cell Research 2013, 23, 1106–1118 5. Yun Du, Huaiyu Yang*, Yechun Xu, Xiaohui Cang, Cheng Luo, Yanyan Mao, Yuanyuan Wang, 4 Guangrong Qin, Xiaomin Luo, Hualiang Jiang*. Conformational Transition and Energy Landscape of ErbB4 Activated by Neuregulin1β: One Microsecond Molecular Dynamics Simulations. Journal of the American Chemical Society 2012, 134, 6720-67316. Ye Yu, Zhi Chen, Wei Guang Li, Hui Cao, En-Guang Feng, Fang Yu, Hong Liu, Hualiang Jiang*, Tian-LeXu*. A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel. Neuron 2010, 68, 61-72 7. Xiaofeng Liu, Sisheng Ouyang, Biao Yu, Yabo Liu, Kai Huang, Jiayu Gong, Siyuan Zheng, Zhihua Li, Honglin Li*, Hualiang Jiang*. PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach. Nucleic Acids Research.2010, 38, W609-W614 8. Huaiyu Yang, Ye Yu, Wei GuangLi, Fang Yu, Hui Cao, TianLe Xu*, Hualiang Jiang*. Inherent Dynamics of the Acid-sensing Ion Channel 1 Correlates with the Gating Mechanism. PLoS Biology 2009, 7, e** 9. Honglin Li, Jin Huang, Lili Chen, Xiaofeng Liu, Tong Chen, Jin Zhu, Weiqiang Lu, Xu Shen, Jian Li*, Rolf Hilgenfeld*, Hualiang Jiang*. Identification of Novel Falcipain-2 Inhibitors as Potential Antimalarial Agents through Structure-Based Virtual Screening. Journal of Medicinal Chemistry. 2009, 52, 4936-4940 10. Lingyang He, Liang Zhang, Xiaofeng Liu, Xianghua Li, Mingyue Zheng, Honglin Li, Kunqian Yu, Kaixian Chen, Xu Shen, Hualiang Jiang*, Hong Liu*. Discovering Potent Inhibitors Against the beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) of Helicobacter pylori: Structure-Based Design, Synthesis, Bioassay, and Crystal Structure Determination. Journal of Medicinal Chemistry 2009, 52, 2465-2481
jyjl:中国科学院上海药物研究所药物化学 博士
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